TransplantDirect

The July issue of @TXPDirect is jam-packed with useful information for our diverse international transplantation readership. We welcome you to visit our Transplantation Direct website for full details in open-access. #OpenAccess #TransplantTwitter bit.ly/TXDissue

🩺 This 8-year study of vascularized composite allotransplantation (#VCA) recipients found an early decline in kidney function that largely stabilized over time. #Transplantation #Immunosuppression #TXPforALL tinyurl.com/45rtvra2

This study demonstrates the potential of temporal PGD classification for improving our understanding of how the dynamic nature of PGD affects survival. #LungTransplantation #TXPforALL tinyurl.com/3k4dpktf

🔬 A biological solution for complex hernias? Donor rectus fascia allotransplantation restored abdominal wall integrity in patients where conventional mesh repair was not feasible. Early results are encouraging. #TXPforAll #transplantation #Surgery tinyurl.com/379bybek

🦠 Norovirus after #Transplantation remains a major clinical challenge. Which treatments actually work? This comprehensive scoping review of 58 studies finds promising signals—but highlights a striking lack of high-quality evidence. #TXPforAll #OpenAccess tinyurl.com/yuxdpmza

New insights into transplant tolerance: this study identifies IL-35 as a key mediator of bidirectional immune regulation after HLA-identical kidney #transplantation. Exosome-delivered IL-35 may help sustain local graft tolerance. #Immunology #TXPforAll tinyurl.com/4rbhjxn4

From bench to bedside: this review highlights the latest advances in vascularized composite allotransplantation (VCA), including innovative immunotherapies and improving outcomes in uterus, face, and limb transplantation. tinyurl.com/5n798bv8

📊 Body surface area- and kidney function-based valganciclovir dosing achieved target drug levels more often than weight-based dosing and was linked to faster CMV clearance. #TXPforALL #Transplantation tinyurl.com/24jpfz79

🫁 In a mouse model, delayed treatment reduced chronic airway injury and inflammation, but earlier therapy provided greater protection. #LungTransplantation #CLAD #TXPforALL tinyurl.com/8p7tjfdz

In a study of 1,146 liver transplants with up to 10 years of follow-up by Pollmann et al., sex mismatch was not an independent predictor of survival after adjustment. Bottom line: donor sex alone should not limit donor selection. 🫀➡️🫁 tinyurl.com/45s85xf4

New study shows remarkable growth in U.S. Good Samaritan kidney donation. From 2000–2024, annual donations increased from 17 to 439. Voucher-based nondirected donation grew from 2 donors in 2015 to 314 in 2024, representing 72% of Good Samaritan donations. tinyurl.com/msd6wbxb

Prior Roux-en-Y gastric bypass may increase the risk of malabsorption, sarcopenia, recurrent steatohepatitis, and graft loss after liver transplantation. These cases highlight the importance of careful nutritional assessment and long-term monitoring. tinyurl.com/bpn6jke3

Should age or cancer history determine kidney transplant access is addressed in this paper by Lim et al. #TXPforAll #Transplantation #OpenAccess tinyurl.com/4upud6vk

CTLA4-Ig combined with anti-IL-6/IL-6R therapy improved graft function, resolved CNI toxicity, reduced donor-specific antibodies, and promoted a more regulatory immune profile. #TXPforAll #KidneyTransplantation #OpenAccess tinyurl.com/37fpzavf

🦠Norovirus remains a major challenge after solid transplantation! This scoping review highlights promising signals for oral immunoglobulin and fecal microbiota transplantation, but robust clinical trials are urgently needed. #TXPforAll #Transplantation tinyurl.com/j8mxd5jx

🧪Can urine recirculation improve kidney preservation? In discarded human kidneys, urine recirculation during normothermic machine perfusion supported longer perfusion times and a more favorable metabolic profile. tinyurl.com/msaeyv83

💪Muscle loss after kidney transplantation may be more than a marker of frailty. CT-based body composition analysis identified accelerated skeletal muscle decline in patients with allograft dysfunction and predicted poorer survival. #TXPforAll tinyurl.com/yrww5yav

This study highlights robust CLAD development across models and supports B6-background donor lungs as a valuable platform for studying chronic rejection and testing new therapies after lung transplantation.#TXPforAll #Immunology #OpenAccess tinyurl.com/bdze57f3

The June issue of @TXPDirect is jam-packed with useful information for our diverse international transplantation readership. We welcome you to visit our Transplantation Direct website for full details in open-access. #OpenAccess #TransplantTwitter bit.ly/TXDissue

Living kidney donors reported improving pain control with very limited opioid use by 2 weeks after donation. #TXPforAll #Transplantation #OpenAccess tinyurl.com/2fhm7f6b