Teddy Yewdell

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Teddy Yewdell

Teddy Yewdell

@TYewdell

Group Leader/Principal Scientist @Genentech. B cells, autoimmunity, immune memory, tiki taka & geggenpressing

Menlo Park, CA Katılım Kasım 2020
801 Takip Edilen2K Takipçiler
Memorial Sloan Kettering Cancer Center
🎉Congratulations to MSK pathologist Dr. Alexander Gitlin for being named a 2026 Pew-Stewart scholar! Dr. Gitlin will uncover how cell signaling controls the nature and magnitude of inflammation in normal physiology and in disease, focusing on the intersection of inflammatory signaling and cell death pathways.
The Pew Trusts@pewtrusts

And finally, meet the 2026 Pew-Stewart scholars. These five scientists are tackling some of cancer research’s biggest questions, from pioneering new strategies to engineering lifesaving treatments. pew.org/en/about/news-…

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Oded Rechavi
Oded Rechavi@OdedRechavi·
Every PI
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Aaron Ring
Aaron Ring@aaronmring·
Always consider FcR interactions when staining cells of myeloid lineage. And block them. This happens more often than you would think!
Oncology News@Oncologynewspro

🚨 BCMA in #AML: "High expression" was artifact—clone 19F2's Fc-FcR binding, not real antigen. REA315 confirmed minimal BCMA. CAR-T failed. Transcriptomics: TNFRSF17 << CD33/CD123. Multi-method validation before target design is essential. @JITCancer #Hematology

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Oded Rechavi
Oded Rechavi@OdedRechavi·
I think I’ll start posting about the lessons I’m learning as part of this new thing I’ve been doing (my attempt to change the landscape of scientific publishing and consequently how science is done) One lesson I’ve learned (and also unlearned…) is that it’s very convenient to put all the blame on journals. I’ve done it myself for years. And yes, many of the criticisms are valid. They make way too much money at our expense and are often not very good at distinguishing good science from bad science. Some of them (not all of them! There are good journals too!) bring very little value and can even slow scientific progress. They can be inefficient and biased, and journal names are a very poor substitute for quality. But the more I work on this, the harder it is for me to believe that journals are the only problem (even specifically when it comes just to publishing science). Universities are equally at fault. And I don’t just mean that we, the scientists doing the reviewing, are part of the problem (which we are, obviously). I mean the institutions we belong to, and the way they make decisions. Hiring, promotions, funding allocation - these processes are often opaque, subjective, and not particularly scientific. They are slow, inefficient, and they rely on journal brands as a shortcut. I used to think journals were driving this, but it’s obviously more like a loop. Journals could not stay the way they are if universities changed how they evaluate quality, because they would lose much of their justification to exist. But universities do not evaluate science directly, because there is too much of it and not enough experts available and time (or money to pay reviewers). So they rely on journal prestige, while journals rely on institutional reputation. Where you do your science ends up mattering more than what you discover, and this affects publication, which affects funding, which determines whether you can even pursue your ideas. This can be exploited, of course, but I don’t think institutions (or the responsible faculty/management) behave this way because they are evil or greedy. They do it because evaluating science properly is ridiculously hard and time-consuming, and the system does not reward doing it well. But the important question is can we change the way our universities work, or is it an impossible task? What I've learned working on this problem is that we can. In addition to engaging with management we can influence the system in other ways. In many cases we don’t need their approval. We are the ones who form the committees. I believe we can break the loop, if we target the mechanism of science evaluation. Journals will keep their power, shortcuts will keep dominating, and the same biases will keep reproducing themselves unless we change how we evaluate science (how we do review). If we can find ways to critically evaluate science at scale, rigorously and transparently, we can change how decisions are made.
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Prof. Akiko Iwasaki
Prof. Akiko Iwasaki@VirusesImmunity·
Very proud of @Kwon_Dongil, @sachinbhag, and Stephen Ehrenzeller for putting together a new review - "Harnessing mucosal immunity for protective vaccines" published today @NatRevImmunol! Please use the link below to access this review 📖 rdcu.be/e4eEU
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Teddy Yewdell
Teddy Yewdell@TYewdell·
This has been making the rounds, and rightly so - an excellent argument to spend more time thinking, and less time generating data. Suboptimal title to sit behind a paywall though! 😅😬 nature.com/articles/s4157…
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Teddy Yewdell
Teddy Yewdell@TYewdell·
Only 3 days left to apply for a Summer Internship in the Yewdell Lab. Don't miss out on the chance to gain exposure to what a job in "industry" actually looks like, and get a leg up towards advancing your career. Apply now! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…
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Teddy Yewdell@TYewdell·
@mbeisen @CalFootball that QB draw play he made was NUTS - didn't look like he was going to make it, let alone score when he took off
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Michael 英泉 Eisen
Michael 英泉 Eisen@mbeisen·
This is @CalFootball slander. Mendoza left Cal - who were the only school to give him a real chance and were eager to build around him - because he thought going to Indiana would be better for his career. Only then did Cal bring in a replacement. It may have been the right call for him (we'll never know) but it's a lie to say Cal quit on him.
DK🇺🇸🦅🇺🇸@1Nicdar

130 schools said no. He led the losingest program in college football history to a national championship anyway. Fernando Mendoza was a 2-star recruit from Miami. He tried to walk on at his hometown school. They passed. So did FIU. So did FAU. So did everyone else. At 17, he was sitting in his bedroom, crying over a silent recruiting inbox—after driving to 18 camps with his dad and sending highlights to more than 100 programs. Not one FBS offer. His only option? Yale. No scholarship. No NFL path. Everyone told him to be “realistic.” “Know your place.” “Be grateful.” He didn’t listen. Because Mendoza understood something most people miss: The worst outcome isn’t failing. It’s never getting the chance to try. Two weeks before signing day in 2022, his phone rang. Cal needed a body. One offer. Out of 134 schools. He took it. He arrived as the third-string quarterback. Spent a year on the scout team. Lost his first four starts. Got sacked 41 times behind a broken offensive line. Still got up. Every time. Then Cal brought in a transfer instead of building around him. So Mendoza left the only school that had ever said yes. He transferred to Indiana—the losingest program in college football history. People laughed. “Career suicide.” “Graveyard program.” “Nobody wins there.” One coach told him something different: “I’m going to make you the best Fernando Mendoza possible.” That was enough. Mendoza wasn’t just playing for football. His mother has battled multiple sclerosis for 18 years. Before every snap, he thought of her. “My mother is my why.” Indiana went 16–0. Beat six Top-10 teams. Won their first Big Ten title since 1945. Mendoza threw 41 touchdowns. Won the Heisman—first in school history. First Cuban-American to ever do it. Then came the title game. Miami. Near his hometown. Fourth-and-4. Season on the line. Quarterback draw. The kid 134 schools rejected spun through defenders and dove into the end zone. Game over. Indiana—national champions. The losingest program became the best team in America. All because a 17-year-old refused to believe “no” was the end. Rankings don’t decide your ceiling. Gatekeepers don’t write your ending. Being overlooked isn’t a verdict—it’s a starting point. Sometimes all you need is one shot… and the courage to bet on yourself when nobody else will. Don’t quit. Credit: Barclay Mullins

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Teddy Yewdell
Teddy Yewdell@TYewdell·
The OG Yewdell lab @NIH is recruiting a postdoc to study MHC class I antigen processing and presentation and/or influenza A virus immunobiology, deets below. Outstanding track record of trainees getting faculty positions + Jon will play you in ping pong in lab at any time
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Oded Rechavi
Oded Rechavi@OdedRechavi·
How did running your first Western Blot feel? Student:
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Teddy Yewdell
Teddy Yewdell@TYewdell·
THIS IS SO COOL!!! EVERYONE who has ever written a paper needs to try this ASAP. Take your favorite paper that you have written, put it in, and I guarantee you will be blown away by the feedback.
Oded Rechavi@OdedRechavi

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has on the well-being of myself, my team, and pretty much every scientist I know (maybe you’ve noticed from my stupid jokes… :) I was exhausted of dealing with the huge delays, reviewers that can be abusive, and how arbitrary it all is. Unfortunately, the most important factors are often WHO your reviewers are and who YOU are... It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers. It can be a real difference maker if many of you join us (thousands have tried it already, but today we release a NEW and much stronger version ;) Let’s harness qed to put the power back in the scientists’ hands, to do, to read & to publish science on our own terms. I’m dying for you to TRY IT, and it’s very simple - just drop a paper (the link to the website is in the replies👇) - it’s completely secure, private, and free, and you get results fast. Please show your support, SHARE, tell your friends, and let’s be the revolution 🫵!

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Teddy Yewdell
Teddy Yewdell@TYewdell·
Turns out KPop demon hunters is AWESOME!!!! #dads
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Teddy Yewdell
Teddy Yewdell@TYewdell·
Don't forget to sign up for the B cell-T cell/plasma cell Joint Keystone meeting - short talk abstracts due 11/13 - hope to see you there!
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