

Teddy Yewdell
698 posts

@TYewdell
Group Leader/Principal Scientist @Genentech. B cells, autoimmunity, immune memory, tiki taka & geggenpressing








130 schools said no. He led the losingest program in college football history to a national championship anyway. Fernando Mendoza was a 2-star recruit from Miami. He tried to walk on at his hometown school. They passed. So did FIU. So did FAU. So did everyone else. At 17, he was sitting in his bedroom, crying over a silent recruiting inbox—after driving to 18 camps with his dad and sending highlights to more than 100 programs. Not one FBS offer. His only option? Yale. No scholarship. No NFL path. Everyone told him to be “realistic.” “Know your place.” “Be grateful.” He didn’t listen. Because Mendoza understood something most people miss: The worst outcome isn’t failing. It’s never getting the chance to try. Two weeks before signing day in 2022, his phone rang. Cal needed a body. One offer. Out of 134 schools. He took it. He arrived as the third-string quarterback. Spent a year on the scout team. Lost his first four starts. Got sacked 41 times behind a broken offensive line. Still got up. Every time. Then Cal brought in a transfer instead of building around him. So Mendoza left the only school that had ever said yes. He transferred to Indiana—the losingest program in college football history. People laughed. “Career suicide.” “Graveyard program.” “Nobody wins there.” One coach told him something different: “I’m going to make you the best Fernando Mendoza possible.” That was enough. Mendoza wasn’t just playing for football. His mother has battled multiple sclerosis for 18 years. Before every snap, he thought of her. “My mother is my why.” Indiana went 16–0. Beat six Top-10 teams. Won their first Big Ten title since 1945. Mendoza threw 41 touchdowns. Won the Heisman—first in school history. First Cuban-American to ever do it. Then came the title game. Miami. Near his hometown. Fourth-and-4. Season on the line. Quarterback draw. The kid 134 schools rejected spun through defenders and dove into the end zone. Game over. Indiana—national champions. The losingest program became the best team in America. All because a 17-year-old refused to believe “no” was the end. Rankings don’t decide your ceiling. Gatekeepers don’t write your ending. Being overlooked isn’t a verdict—it’s a starting point. Sometimes all you need is one shot… and the courage to bet on yourself when nobody else will. Don’t quit. Credit: Barclay Mullins




Now online! Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells dlvr.it/TPdpN6

Pre-print alert! And this one really is a must read for anyone that does spectral flow cytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? biorxiv.org/content/10.110…

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has on the well-being of myself, my team, and pretty much every scientist I know (maybe you’ve noticed from my stupid jokes… :) I was exhausted of dealing with the huge delays, reviewers that can be abusive, and how arbitrary it all is. Unfortunately, the most important factors are often WHO your reviewers are and who YOU are... It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers. It can be a real difference maker if many of you join us (thousands have tried it already, but today we release a NEW and much stronger version ;) Let’s harness qed to put the power back in the scientists’ hands, to do, to read & to publish science on our own terms. I’m dying for you to TRY IT, and it’s very simple - just drop a paper (the link to the website is in the replies👇) - it’s completely secure, private, and free, and you get results fast. Please show your support, SHARE, tell your friends, and let’s be the revolution 🫵!




