Bryson Lab

Anyone in the de novo minibinder design space using their binders as flow cytometry staining reagents? Would love to compare notes if so!

Thanks to our many collaborators at the @ragoninstitute and across the broader community and our funders #tuberculosis Congrats especially to Owen and Rachel, the two fearless graduate students who led this work -- y'all are the best <3

We're excited! This study supports the concept that there are multiple ways to transfer proteins from the phagosome to the cytosol, and that Mtb specifically takes advantage of this.

Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: biorxiv.org/cgi/content/sh… This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070

Last, a major thanks to our funders and excellent collaborators! Please reach out if there's anything in the paper that interests you!

We think this work is important because: 1. It helps us think about species differences in new ways 2. It highlights a metabolic gate in Mtb-host interactions 3. It may help resolve long-standing challenges in translating concepts from mouse studies to humans

Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): biorxiv.org/content/10.110…