The McLuckey Lab at Purdue

Seth is on a roll 😎, the man has published/co-published three papers in the last 3 months 🫡👷. For ion-ion reaction aficionados - Parallel valet parking: selective ion escape over an AC barrier during ion/ion reactions in a quadrupole linear ion trap cdnsciencepub.com/doi/full/10.11…

Congratulations to our entire cohort of third-year students, specially Mr. Ellin and Zuzu (Boukar). Interestingly, all those guys started their program together. Classic example of team effort 👌 👌🏿. Hope you enjoy the reading 😁.

You say you are a proton transfer charge reduction (PTCR) user? We have something for you 😎: Proton transfer reagent cations for ion–ion charge state manipulation of high mass negatively-charged analytes in an electrodynamic ion trap pubs.rsc.org/en/content/art…

Recently, we developed a couple of methods to aid in the mass analysis of proteins dissolved in physiologically relevant conditions. Now, we are showing why it is important to preserve proteins native environment. The conformational dynamics simply change. pubs.rsc.org/en/content/art…

📢🔊 A must read 🤓 Ion-Ion Chemistry for the Analysis of Biomolecular Ions via Tandem Mass Spectrometry: A Tutorial Review. A dish served by Seth, Nick and Scott (I am sure they speak on behalf of the group). Please don't miss it. go.shr.lc/4sahkCU

Congratulations to Swetashree and Seth for their recent publication 🥳. Tune in to learn about reactivity of noble metal nanoclusters in the gas phase. This was an excellent Purdue-IIT collaboration. 👏 pubs.acs.org/doi/full/10.10…

Big congratulations to our very bright and hardworking Dr. Erick Baez Bolivar for defending his dissertation today! He's accomplished so much during his time with us including an internship at Merck in California. His passionate energy will be missed dearly!

It is a pleasure for us to announce that our dear Sam recently started a postdoc position at @EliLillyandCo. She will be scientifically entertained in the Protein Synthesis Lab 🤓. We wish her a successful postdoc 😀. Have fun and learn a lot Sam 🤗!

Our dear Sam defended her PhD thesis last week, we couldn't be prouder. Dr. Mehnert, you will be immensely missed!!!..thanks for everything you have been doing for the group, from scientific contributions to keeping the culture of the lab alive and thriving. Next stop..stay tuned

⚛️ “You can’t plan discoveries – but you can plan work that’s likely to lead to discoveries.” In this article, Scott A. McLuckey (@LifeAtPurdue) shares his lifelong passion for curiosity-driven science and the thrill of turning over stones in mass spectrometry. 🔗 ow.ly/Yr6K50XbMFB #MassSpec

Recently, The Analytical Scientist interviewed our very own Scott McLuckey! Read about his journey and research philosophy below: theanalyticalscientist.com/issues/2025/ar…

Here is our dear Nick Pizzala presenting his research to the wide audience of the @TopDownProteome. Although our guy has no problem talking, it is an 8-minute summary of excellent research. youtu.be/59IKJKaMTW0?si…

@UFChemistry is searching for an Assistant Professor in #AnalyticalChemistry! Join our vibrant and state-of-the-art program and faculty! Apply by Oct. 31. careers.pageuppeople.com/674/cw/en-us/j…

Now, if you are interested in relatively high MW proteins (466 kDa tested in our work), please use small portions. The thing can be sticky. We explained the recipe in the manuscript. Happy reading!

Starting with a simple desire to improve reproducibility of the spectra, we found out significant improvements on repeatability, S/N, FWHM (less metal ion adduction), and robustness. If you are interested in small proteins, the house suggests going all-in solution additives

Improved Mass Analysis of Proteins and Protein Complexes Present in Common Biological Buffers and Physiological Concentrations of NaCl Using Solution Additives Delivered by Theta Emitters | Analytical Chemistry pubs.acs.org/doi/10.1021/ac…

It's (e)lit! We have a new article about the homebuilt nested ELIT, which allows for an extended mass range while also maintaining higher resolution. Read below to see how it works! doi.org/10.1016/j.ijms…

In this work, we apply DDC to doubly-charged bradykinin. However, using an MCP can result in ions with different charges being detected at different efficiencies, which leads to incorrect calculations. How do we account for this? Find out below! doi.org/10.1016/j.ijms…

We have several staff positions open in our Amy Instrumentation Facility. Check them out: chem.purdue.edu/facultyopening… #chemjobs

This Special Issue honors Prof. Dame Carol Robinson, 2023 ASMS John B. Fenn Award recipient. Featuring works from esteemed authors she invited, showcasing her transformative impact on native & structural mass spectrometry. Read it here: brnw.ch/21wTFRW @ASMSnews