ASCI

ASCI member Kristopher T. Kahle @MassGeneralNews and colleagues provide a Review! 👇

How does caloric restriction reduce energy expenditure while preserving energy storage? doi.org/10.1172/jci.in… Alan R. Saltiel @LabSaltiel & team @UCSanDiego show TBK1 acts as a brake on fat burning during fasting—and the combination of a TBK1 inhibitor and an AMPK activator reverses obesity and improves #MetabolicHealth in mice. The figure: Combined TBK1 inhibition and AMPK activation improve metabolic health in obese mice.

@HopkinsMedicine Severity-dependent atrial remodeling and atrial fibrillation vulnerability in a clinically relevant aortic regurgitation mouse model: doi.org/10.1172/jci.in…

~10% of individuals with cystic fibrosis are unresponsive to CFTR modulators. doi.org/10.1172/jci.in… Here, ASCI member Garry R. Cutting & team @HopkinsMedicine report on gene editing for the correction of a common disease-causing variant in primary CF airway cells. #CysticFibrosis #CF

Spotlighting ASCI member @aadel_chaudhuri 👏

Nature research paper: Non-invasive profiling of the tumour microenvironment with spatial ecotypes go.nature.com/4wf1BFl

This Research Article has high translational potential for #ProstateCancer therapy: doi.org/10.1172/jci.in… Jindan Yu @yu_jindan & team @EmoryMedicine find the new-generation AURKA inhibitor VIC-1911 suppresses prostate cancer growth as a single agent and further increases sensitivity to PARP inhibitors. The figure: VIC-1911 significantly inhibits PC tumor growth either as a single agent or in combination with PARPi. w/@bilenma

This Research Article advances our understanding of how metabolism shapes neuronal development: doi.org/10.1172/JCI197… Ralph J. DeBerardinis & team @UTSWMedCenter generated neural progenitor cells from patients with L2HGDH deficiency, finding L-2HG accumulation epigenetically activates MYC to impair neural differentiation—and the effect is reversible by gene editing or pharmacologically. The figure shows MAP2 (red) and β-III-tubulin (green) in corrected neurons; DAPI (blue). #Neurodevelopment

A landmark in cardiac metabolism: doi.org/10.1172/JCI202… Jay D. Horton & team @UTSWMedCenter find unrestrained fat oxidation in heart cells deplete cardiolipins that are needed for mitochondrial energy, triggering heart failure in mice and revealing a potential metabolic target. The figure shows decreased heart function in cardiac-specific ACC1/ACC2 double KO (dHKO) mice. #CardiacMetabolism #HeartFailure

Deeply grateful to be elected into the American Society for Clinical Investigation (ASCI) — a reflection of the extraordinary group of trainees and colleagues @SmithBIDMC and beyond. @the_asci

Congratulations @rkwadhera on your induction into @the_asci, in recognition of his exceptional contributions to cardiovascular and health policy research! Read more here: smithcenter.bidmc.org/news/dr-rishi-…

Join us in celebrating #WashUMedCRTC alumni Suzanne Schindler, MD, PhD; Christopher Smyser, MD; and Sidharth (Sid) Puram, MD, PhD on their recent election to @the_asci! Learn more about this distinguished honor: bit.ly/4ubrSD2 @WashUMedENT @WashUNeurology

✅Clear association with disease severity ✅Mechanistic insight ✅Robust multi-platform design doi.org/10.1172/JCI194… In this Research Article, Deepak A. Rao @Deepakarao & team @BrighamWomens implicate CD57+ T effector memory cells as a driver of lung injury in systemic sclerosis-interstitial lung disease (SSc-ILD) and potentially other forms of ILD. The figure shows CD57+, CD8+, and CD45RA+ staining of SSc-ILD lung tissue.

#StanDOM's @Joseph_C_Wu receives @the_asci's 2026 Stanley J. Korsmeyer Award, which recognizes physician-scientists for scientific excellence, innovation & mentorship. Wu delivered the Korsmeyer Lecture, "Genomics, AI & NAMs for Drug Discovery" at ASCI's annual meeting.

“Being inducted into @the_asci is a tremendous honor and a meaningful acknowledgement of the importance of our work to understand the pain experience and its underlying mechanisms in individuals with #autoimmune #RheumaticDiseases. I am deeply grateful to the mentors, collaborators, trainees, and the patients whose partnership and insight inspire the questions we pursue,” Yvonne Lee, MD, MMSc, said. news.feinberg.northwestern.edu/2026/04/15/fei…

Congratulations to Drs. @SoleimanpourLab and @adina_turcu, who were recently inducted into The @the_asci! Learn more about the society and their research at beta.the-asci.org.

“It’s a tremendous honor to be part of such a historic and prestigious organization. @the_asci has long been home to physician-scientists who have fundamentally changed the way we understand and treat disease, and I’m deeply grateful to join their ranks,” said Seth M. Pollack, MD (@immunosarc), who is also a co-leader of the #CancerImmunology and #Immunotherapy Initiative at @LurieCancer. Read more: news.feinberg.northwestern.edu/2026/04/15/fei… #SarcomaImmunobiology

Despite efforts to identify new druggable targets in #LungAdenocarcinoma, many patients remain in the category of oncogene-negative doi.org/10.1172/jci.in… Here, D. Neil Hayes & team @uthsc identify EGFR-associated genomic and transcriptomic signatures that refine lung adenocarcinoma taxonomy and reveal treatment opportunities in patients previously labeled as having no actionable mutations. The figure shows the proposed framework linking 4 biological components across lineage-defined molecular subtypes of lung adenocarcinoma. #LungCancer

How do monogenic disorders drive calcification? doi.org/10.1172/JCI193… Here, Arjun Deb @DebLab8 & team @dgsomucla use model of cardiac calcification in Abcc6-deficient mice, finding the liver regulates ectopic calcification of target tissues in the rare disease Pseudoxanthoma elasticum by altering the metabolome and cellular respiration of target organs. The image shows immunostaining of the injured region revealing hydroxyapatite crystals (green) and myocytes (red) in injured hearts from Abcc6-KO mice.

Neuroendocrine and neural control of bone mass in health and disease: doi.org/10.1172/JCI203… In this Review, Mone Zaidi et al. @IcahnMountSinai discuss the medical consequences arising from dysfunction of two neural pathways that regulate bone mass and explore promising therapeutic targets. #BoneBiology