The_Real_Fly

@kimmonismus @cremieuxrecueil What else does it do? Kill you?

One injection, 62% lower LDL - permanently. Gene editing for cholesterol is here. .@cremieuxrecueil is correct. Besides GLP-1 antagonist like Ozempic or, more recently, Retatrutide, this is probably the next breakthrough that is almost impossible to put into words. Verve Therapeutics (Eli Lilly) just published Phase 1 results for VERVE-102 in the NEJM. It's a single-infusion base-editing therapy that inactivates PCSK9 in the liver. At the highest dose, PCSK9 dropped 88% and LDL cholesterol fell 62%. Reductions held for at least a year. 35 patients with familial hypercholesterolemia or premature coronary artery disease. No dose-limiting toxicities. Main side effects: mild infusion reactions and transient liver enzyme elevations. Still Phase 1, still small, no cardiovascular outcome data yet. But the proof of concept for permanent, one-shot LDL reduction via gene editing is real. This is an absolute game changer and im not exaggerting. Elevated LDL cholesterol is responsible for an estimated 4.4 million deaths every year worldwide and remains the single biggest modifiable driver of cardiovascular disease, the leading cause of death globally.

What a peace deal

Oh well

Saudi Arabia says it will only normalize relations with Israel if there is an irreversible pathway to a Palestinian state.

Insane request

😂

Israeli Finance Minister Bezalel Smotrich: For every Hezbollah explosive drone, 10 buildings in Beirut should fall.

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IRAN'S FOREIGN MINISTRY SPOKESPERSON SAYS WE WILL NOT TAKE TOLLS ON THE STRAIT OF HORMUZ

NASDAQ FUTS +360

US 10YR -8BPS

GOYSLOP

Incredible

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Trump told some Arab and Muslim leaders that he 'wants their nations to sign peace agreements with Israel' if a deal is reached to end the Iran war, according to Axios report.

Pakistan official says Iran agreed to hand over enriched uranium in Trump-backed deal, report claims.

@emilmalek8752 If the investigation proves he was working for a foreign govt absolutely

@The_Real_Fly So arrest Trump and all his MAGA goons first?

In a proper American administration, an investigation should be conducted to try and convict all parties in govt working on behalf of Israel to further their national interests over ours. The two do not intersect and are negatively correlated.

The man being sued for $175m by Mayweather is Jona Rechnitz. His Father Robert is Sen. Graham’s handler, was his national finance co chair during his Presidential run, a close friend.

IG WEEKEND OIL -6% God forbid Americans should get to save some money at the pump. These monsters want crude at $250 and American soldiers in body bags for a foreign country