Thiago J Borges, PhD

🐷➡️🧬 In the first pig-to-human kidney transplant, a multiomics approach demonstrated that persistent innate immune activation (monocytes/macrophages) remains a key barrier. Better control of innate immunity will be critical for future success.

Incredible opportunity to lead our Living Donor Kidney Transplant Program @mgh_transplant Join a collaborative, high-volume team (>240 tx/year) with real momentum in innovation and program growth (tolerance/xeno) Know someone great or interested yourself: jobs.myast.org/job/kidney-tra…

Looking forward to speak at the @AST_COTS Guest Symposium at the #IMMUNOLOGY2026™ @ImmunologyAAI with @ValeriaMas11

We’re very excited to be hosting the first Glomerular Disease Conference in Boston on May 30th! Join us to learn what’s new in glomerular diseases from world-class experts. In-person and virtual options available. Fellows/trainees can attend for free. DM for details.

Check out our latest paper @amjtransplant 👇🏼👇🏼

Historic moment in transplant medicine. Tim, our @mgh_transplant xenotransplant patient, who previously received a gene-edited pig kidney and was off dialysis for 9 months, has now received a human kidney. A new chapter in care and hope. cnn.com/2026/01/16/hea…

I’m very proud to have been the first Editorial Fellow on the Basic Science track @amjtransplant This experience has been incredibly valuable for my development as a scientist. I strongly recommend this program to anyone interested in academic publishing.

A brief T–cell–mediated rejection occurred early, likely due to residual lymph node immunity, but was successfully treated. No antibody-mediated rejection was seen. @LVRiella @MassGeneralNews

🐷➡️🧬 In the first pig-to-human kidney transplant, a multiomics approach demonstrated that persistent innate immune activation (monocytes/macrophages) remains a key barrier. Better control of innate immunity will be critical for future success.

Hot off the press @NatureMedicine: We report the first high-dimensional immune profiling of a living human recipient of a gene-edited pig kidney at @MGH_Transplant / @MGBKidneys, defining the evolving human xeno-immune response over time. nature.com/articles/s4159…

In honor of Richard Slayman, the first pig kidney recipient, we hosted a workshop gathering global experts in xenotransplantation to explore unpublished clinical and ethical advances in kidney, heart, and liver transplantation. #Xenotransplantation #TransplantInnovation

Scientists have found that C/EBP⍺ activates an IRF8 #enhancer, driving its expression in early myeloid progenitors and specifying type I conventional #DendriticCell lineage. @washu_pathology @JingNeticist Read more in Science #Immunology: scim.ag/3EUH8jF

He’s thriving nearly 4 months after receiving a gene-edited pig kidney at @mgh_transplant @MGHSurgery @MGHKidneys @harvardmed. “He was tired of just surviving. A pig kidney gave him a shot at living.” @CNN 🔗 cnn.com/2025/05/14/hea…

@LVRiella @MGHSurgery @AST_info @karinarlima @CrisBonorino

💡 Takeaway: Innate immune checkpoints like Siglec-E/7/9 are emerging as crucial regulators of transplant rejection. 4/5 📄 Newsroom @MGBResearchNews: massgeneralbrigham.org/en/about/newsr…

🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/5 science.org/doi/10.1126/sc…

🚨 Great Opportunity! 🚨 The @LVRiella lab, @mgh_transplant, is seeking a Postdoc in Transplant Immunology with expertise in Microsurgery. 📍 Apply now! #Postdoc #Microsurgery #TransplantResearch

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🚨 Breaking Records Again! 🚨 For 13 years in a row, our transplant teams have saved more lives through #OrganTransplantation than any hospital in New England. 👏 Shoutout to our patients, care teams and researchers for an amazing year in 2024! #TransplantInnovation #DonateLife