Tony Li

74 posts

Tony Li

Tony Li

@TonyLiHQ

PhD student @uwgenome

Katılım Haziran 2021
193 Takip Edilen61 Takipçiler
Tony Li retweetledi
Sudarshan Pinglay
Sudarshan Pinglay@sudpinglay·
Now out in @ScienceMagazine we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment. science.org/doi/10.1126/sc…
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Nature Methods
Nature Methods@naturemethods·
Out yesterday from the Akilesh and Beliveau labs! pSABER decorates in situ nucleic acid targets with binding sites for an HRP-conjugated oligo, enabling the localized deposition of fluorescent or colorimetric substrates for highly amplified signal. nature.com/articles/s4159…
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Yi Fu
Yi Fu@Yi__Fu·
Excited to share my PhD work in @Agnelsfeir’s lab describing a method to engineer mitochondrial DNA deletions in human cells and our exploration of how cellular metabolism and transcription respond to deletion heteroplasmy. biorxiv.org/content/10.110… 1/19
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Silvia Domcke
Silvia Domcke@sdomcke·
New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4
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Troy McDiarmid
Troy McDiarmid@TroyMcDiarmid·
Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” ! biorxiv.org/content/10.110…
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Troy McDiarmid
Troy McDiarmid@TroyMcDiarmid·
Our paper describing a scalable framework for Multiplex, single cell CRISPRa screening for cell-type specific regulatory elements is published! rdcu.be/dUnoq See the linked tweet from my awesome co-lead @FloChardon for updates since the preprint!
Flo Chardon@FloChardon

Genomic tech dev is my favorite area of science, and today our paper describing our multiplex CRISPRa screening method to identify cell type specific regulatory elements is published! rdcu.be/dUnoq

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Flo Chardon
Flo Chardon@FloChardon·
Genomic tech dev is my favorite area of science, and today our paper describing our multiplex CRISPRa screening method to identify cell type specific regulatory elements is published! rdcu.be/dUnoq
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Martin Kircher
Martin Kircher@KircherLab·
We are recruiting two computational biologists/bioinformaticians with ML expertise and a focus on genomics, variant effects and gene regulatory sequences in staff scientist and postdoc roles in Lübeck, Germany. Please find details here: kircherlab.github.io/contact.html
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wei yang
wei yang@VinetteY·
I am so thrilled to share our work of human RA gastruloid finally out on @NatureCellBio. It has been a wonderful journey to work with a fantastic stem cell scientist @Nobu_Hamazaki and many talented collaborators in @JShendure lab. Excited to contribute to the field of stembryo!
Nobu Hamazaki@Nobu_Hamazaki

Excited to share our human RA-gastruloid model in @NatureCellBio! Early retinoic acid supplementation, followed by later Matrigel addition, robustly induces human embryonic morphologies and diverse cell lineages, including somitic, renal, cardiac, and neural cell types in #gastruloid. rdcu.be/dRtj9

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Nobu Hamazaki
Nobu Hamazaki@Nobu_Hamazaki·
Excited to share our human RA-gastruloid model in @NatureCellBio! Early retinoic acid supplementation, followed by later Matrigel addition, robustly induces human embryonic morphologies and diverse cell lineages, including somitic, renal, cardiac, and neural cell types in #gastruloid. rdcu.be/dRtj9
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Jay Shendure
Jay Shendure@JShendure·
Our latest, from the brilliant @wchenomics and @_Choi_Junhong, out in @Nature , is ENGRAM, a multiplex method for symbolic recording of signaling and cis regulatory activity to DNA. Final version (not in preprint) includes integration w/ DNA Typewriter. rdcu.be/dN62L
Will Chen@wchenomics

Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s4158…

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Junhong Choi
Junhong Choi@_Choi_Junhong·
New synthetic biology / molecular recording lab opening in the New York city, and we are hiring at all levels (research tech / grad student / postdoc), so please reach out to me via choij10 _at_ mskcc.org!
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Jay Shendure
Jay Shendure@JShendure·
Finally out in @naturemethods from the brilliant @jb_lalanne & @SRegalad0, our highly quantitive single cell MPRA (scQer), applied to mammalian embryoids to find autonomous enhancers. Bonus = Tornado circular barcodes that are all kinds of useful. OA link: rdcu.be/dHqo1
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Nature Methods
Nature Methods@naturemethods·
scQers are quantitative single cell expression reporters reported by @JShendure and colleagues. They enable high-sensitivity quantitative characterization of developmental cis-regulatory elements at the single-cell level. nature.com/articles/s4159…
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Keşfet

@ScienceMagazine @FloChardon @dschweppe1 @Nobu_Hamazaki @NatureCellBio @JShendure @biorxivpreprint @wchenomics