Will Chen

343 posts

Will Chen

Will Chen

@wchenomics

@DamonRunyon Fellow at Baker lab @UWproteindesign. PhD with @JShendure. mainly at https://t.co/WpSk6RTizP

Seattle, WA Katılım Ekim 2013
690 Takip Edilen768 Takipçiler
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Will Chen
Will Chen@wchenomics·
Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s4158…
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Max Wilkinson
Max Wilkinson@maxewilkinson·
The Wilkinson Lab is open for science! @MSKCancerCenter 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
Max Wilkinson tweet media
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Jay Shendure
Jay Shendure@JShendure·
Super excited re: first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to brilliant Chase Suiter & @Green_Ahn @UWproteindesign on the work! Preprint: biorxiv.org/content/10.110…
Jay Shendure tweet mediaJay Shendure tweet media
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Andrew Favor
Andrew Favor@andrew_favor·
We are pleased to share our new preprint: “De novo design of RNA and nucleoprotein complexes”. This work extends the principles of de novo protein design to RNA and DNA, enabling the generative design of complex multi-polymer structures! (1/6) doi.org/10.1101/2025.1…
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Green Ahn
Green Ahn@Green_Ahn·
pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint biorxiv.org/content/10.110…, we developed computational methods to rationally design pH-sensitive binders. 🧵
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Adam Broerman
Adam Broerman@adam_broerman·
We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.
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Magnus Bauer
Magnus Bauer@kinasekid·
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: biorxiv.org/content/10.110…
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Luke Koblan
Luke Koblan@LukeKoblan·
Excited to announce that this work is now live as a first release article @ScienceMagazine So grateful for this fantatic team and to see this work in wild! science.org/doi/10.1126/sc…
Luke Koblan@LukeKoblan

1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse model of lung metastasis, we dissect how cell-intrinsic and environmental factors coordinately shape tumor evolution in vivo.

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Junyue
Junyue@junyue_cao·
Finally out in @ScienceMagazine! Utilizing the cost-effective EasySci to profile 21 million single-cell transcriptomes across five life stages and diverse sexes/genotypes, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows. We also demonstrate how highly scalable single-cell genomics enables "Functional Cell-omics" to unravel Cell Regulatory Networks at the whole-organism scale. Congratulations to the incredible Zehao Zhang (@Tommyz626) from our lab @RockefellerUniv for leading this work! science.org/doi/10.1126/sc…
Junyue@junyue_cao

What if 1 million scRNA-seq libraries can be prepared within $1k? Here we go 👉 21 million cells from 623 mouse tissues, spanning 5 life stages & 3 genotypes, all in a SINGLE study by ONE remarkable student Zehao @Tommyz626 from our lab @RockefellerUniv! shorturl.at/epsz7

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Will Chen
Will Chen@wchenomics·
@tranmartink clarify: the editorial team made the final figures based on the amazing figures made by the above two.
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Keşfet

@CXchengxiangQIU @MSKCancerCenter @Green_Ahn @UWproteindesign @Nature @JingchuanLuo @LukeKoblan @ScienceMagazine