Treventis

The latest in #Parkinson disease research investigated the role of #lipid membranes in the #amyloid aggregation of #α-synuclein (αS) using Vibrational Sum-Frequency Generation (VSFG) & the new frame-selection method "ViscaSelect". nature.com/articles/s4146…

A link between traumatic #brain injury (TBI) & #tau-related #neurodegeneration has been uncovered. Research revealed repetitive TBI causes abnormal #tau accumulation & brain #degeneration in an in vivo #mouse model. science.org/doi/10.1126/sc…

An alternative role for #parkin has been recently uncovered. Researchers found neuronal activity triggers parkin activation that leads to enhanced #synaptic vesicle recycling however, #mutations impair this, leading to #toxic #dopamine accumulation. cell.com/neuron/fulltex…

The role of reactive #astrocytes during #Alzheimer's disease (AD) pathological progression was recently investigated. The study’s findings suggest that reactive astrocytes significantly impact #brain energy #metabolism in AD, offering new insights. onlinelibrary.wiley.com/doi/10.1002/an…

Targeting early #alpha-synuclein (αS) aggregation, a hallmark of #Parkinson's (PD), is challenging due to its broad #protein interactions. However, αS's first 25 residues can counteract #aggregation, offering a promising target for PD treatments. sciencedirect.com/science/articl…

A new study found that #tau PET tracers help track age-related tau changes in the #brain. [18F]SNFT-1, a newly developed #tracer, shows high selectivity for tau aggregates in #Alzheimer's (AD) brains. Potential for monitoring tau buildup in AD. jnm.snmjournals.org/content/64/9/1…

Treventis will be at BIO Europe in Munich early next month! Please ping us if you would like to meet in person or virtually. linkedin.com/in/chrisbarden/ #treventis #BIOEurope2023

A new study on Autosomal Dominant #Alzheimer's Disease (ADAD) finds that #APOE genotype & education significantly impact age-related #cognitive decline, suggesting #genetic predisposition is not the only determinant of declining cognition in ADAD nature.com/articles/s4146…

#Cerebrospinal fluid #lipoproteins (CSF-Lps) were found to be rich in #proteins key for wound healing, inflammation, & #neural development. Different CSF-Lp subpopulations were also found to contain unique protein combos, suggesting a link to #CNS health. science.org/doi/10.1126/sc…

A new study explores #plasma GFAP levels & 11C-DED brain binding in #Alzheimer's disease (AD) using PET imaging. Both #biomarkers complement each other in assessing different AD stages & the results show different underlying #astrogliosis processes. …arneurodegeneration.biomedcentral.com/articles/10.11…

A new study uncovers a game-changing mechanism in #neurodegenerative diseases! Instead of the expected #neuron-to-neuron transfer, mutant #α-synuclein travels via the brain's lymphatic system, reaching remote brain regions and resembling #Parkinson's. cell.com/cell-reports/f…

A new study sheds light on trauma-induced #Alzheimer's (AD) with a "TBI-on-a-chip" model that could pave the way for targeted AD #treatments. Using the chip, they found that #oxidative stress, #inflammation, and #Aβ42 aggregation spike post-TBI. pubs.rsc.org/en/content/art…

New findings reveal that TRPM7 is reduced in #Alzheimer's disease (AD) patients. In mouse AD models, boosting TRPM7's M7CK #kinase domain restored #cognitive function & preserved #synapses. These results suggest M7CK could be a #therapeutic target for AD. science.org/doi/10.1126/sc…

Researchers explored the role of genetic diversity by modeling tau aggregate-driven pathologies. The study confirmed that #genetic makeup influences tau-related #gene changes, offering a new framework for studying #tauopathies, like #Alzheimer’s disease. rupress.org/jem/article/22…

New research highlights a key player in #Parkinson's disease (PD) onset: Border-Associated #Macrophages (BAMs). Unlike #microglia, BAMs are essential in driving #α-synuclein-related #neuroinflammatory reactions in PD via activation of #CD4 T #cells. nature.com/articles/s4146…

C9ORF72 repeat expansion (CRE), the leading genetic cause for #FTD & #ALS, inhibits neural #stem cell growth & reduces #cortex & #thalamus size during #embryonic development, demonstrating that CRE impacts regions compromised in adult FTD/ALS patients. cell.com/cell-reports/f…

Scientists have isolated #microglia nuclei from #Alzheimer’s disease & control #brains uncovering new #molecular profiles & #gene networks. These findings add valuable insights into the role of microglia in AD, aiding in targeted #therapy development. nature.com/articles/s4358…

Early #Alzheimer's disease (AD) triggers #cognitive deficits due to network dysfunction. KCC2 #protein decline in mice with AD #mutations is linked to rising Aβ42 levels; however, CLP290 administration protects & preserves learning & neuronal cell #death. academic.oup.com/brain/advance-…

New research revealed a unique #amyloid-beta (Aβ) mechanism where formation of nonfibrillar structures within GM1 clusters on the #cell membranes of #neurons catalyze #fibrilization, providing valuable structural insights to guide the design of therapies pubs.acs.org/doi/10.1021/ac…

TRIM11 has recently been found to play a crucial role in guarding against #tauopathies. Its reduced expression could be linked to #neurodegenerative #disease development, making #TRIM11 an excellent #therapeutic target for neurodegenerative tauopathies. science.org/doi/10.1126/sc…