Jennifer Trowbridge

Thrilled to share that our Stem Cells & Developmental Biology program at JAX is officially launched. 40 PIs. 60+ trainees. >$160M in active NIH funding. Fundamental discovery and translational platforms — in the same world. 🔬 go.jax.org/stem-cell-rese… #JAXresearch #JAXstemcellsdev

Congratulations, Justin! isscr.org/isscr-news/the… #JAXresearch #JAXstemcellsdev

It's the final day of #ISSCR2026! Today Justin McDonough from JAX receives the 2026 ISSCR Public Service Award as part of Stem Cell COREdinates and CorEUstem. 🏆 79 institutions. Shared standards. Global access. The infrastructure that enables discoveries. 👇

Filippo Cipriani F1033 automated iPSC islet organoids for population-scale T2D modeling | 4:00 pm Emily Swanzey F1361 cell therapy for macular degeneration via RPE reprogramming | 4:00 pm Affan Mohammed Shaikh F1328 mapping RPE-to-photoreceptor reprogramming in hIPSC | 5:15 pm

Day 3 of #ISSCR2026 🔬 JAX stem cells & development colleagues present new translational work on diabetes and vision loss! 👇 Final day tomorrow, and something special for JAX. Stay tuned. 🏆 #JAXresearch #JAXstemcellsdev

🪧 Cullen Clairmont T1275: modeling intracranial germ cell tumors w/ hPSCs 🪧 Christopher Baker T1404: genome regulatory incompatibilities in diverse mESCs Exhibit Hall, Rm 220 | Booth #605 #JAXresearch #JAXstemcellsdev #NYSCF

Day 2 of #ISSCR2026 🔬 🎤 Stefan Semrau: AI-driven phenotyping of 309 iPSC lines uncovers Parkinson's morphological signatures | 3:00 pm, Room 510a 🪧 Morgan Brady T1323: genetic variation + mESC differentiation

🪧 Posters: Justin McDonough W1149 | Farah Vejzagic W1259 | Enrica Pellegrino W1152 | Exhibit Hall 📍 Booth #605 all week

Day 1 of #ISSCR2026! Big day for JAX & NYSCF: 🍽️ 12:30 pm — JAX-NYSCF Innovation Showcase: scalable iPSC platforms for neurodegeneration | Room 510a (lunch provided) 🎤 3:10 pm — Daniel Paull: scaling iPSC models for drug discovery | Room 510a #JAXresearch #JAXstemcellsdev

Find JAX-NYSCF at Booth #605 Wed-Fri. And watch for news on Justin McDonough receiving the 2026 ISSCR Public Service Award as part of Stem Cell COREdinates 🏆 isscr.org/isscr-news/the… Exciting science from an exciting program! 🔬

JULY 10 🪧 @FilippoCiprian5 (F1033) — iPSC islet organoids for T2D 🪧 @martinperaJAX (F1361) + Affan Mohammed Shaikh (F1328) — RPE reprogramming for macular degeneration | Exhibit Hall

@ISSCR 2026 is almost here (July 8–11, Montréal)! Our JAX Stem Cells & Developmental Biology colleagues have 3 talks and 9 posters across the meeting, plus a JAX-NYSCF Innovation Showcase and Booth #605. Here's the full picture 👇 #ISSCR2026 #JAXresearch #JAXstemcellsdev

Key implication: this alarmin-driven inflammatory axis is active before overt malignancy. Thus, targeting it at the CH stage could suppress mutant stem cell expansion early. #JAXresearch #JAXstemcellsdev 4/4

Tasquinimod (S100A9 inhibitor, now in Phase I/II for myelofibrosis) selectively reduces: ✔️ TNFα & IL-6 production from mutant cells ✔️ Dnmt3a-mutant HSPC frequency ❌ Normal hematopoiesis unaffected Inspired by the foundational work of Helene Gleitz & Rebekka Schneider. 3/4

New preprint from our lab led by @jaynathemistry! 🧬 We asked: what upstream signal ignites the inflammatory cycle that drives clonal hematopoiesis (CH)? Answer: neutrophil-derived S100A8/A9 alarmins. biorxiv.org/content/10.648… 🧵1/4

@bloodgenes Congratulations Vijay!!

🙏 Deeply honored to receive the 2026 Warren Alpert Prize! This award reflects the work by so many to enable transformative therapies for sickle cell disease and thalassemia, and the power of human genetics to reveal biology and guide new treatments! hms.harvard.edu/news/2026-warr…

The ear has a backup! 😮Auditory hair cells can self-correct their orientation after birth even without proteins thought to control it. Congrats to the Tarchini lab, part of our Stem Cells & Development program at JAX! 🎉 #JAXresearch #JAXstemcellsdev journals.biologists.com/dev/article/15…