Identification of 4,5,6,7-Tetrabromo-1H-benzotriazole (TBB) as a Small Molecule MESH1 Inhibitor that Suppresses Ferroptosis biorxiv.org/content/10.648…
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Jen-Tsan Ashley Chi
93 posts
Our JCI study reveals that Coenzyme A defends against #ferroptosis by CoAlating mitochondrial TXNRD2. NBIA and other CoA-defective diseases show vulnerability to ferroptosis, offering a new path to therapy.
jci.org/articles/view/…
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But all through distinct substrates. With the help of Josh Rose in Pei Zhou lab, we have found that the relevant substrate of human MESH1 is NADPH. This is an excellent example of phenotypic conservation through distinct biochemical activities.
nature.com/articles/s4225…
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Similarity #3. MESH1 removal, like stringent response, also triggers proliferation arrests and nucleotide depletion. Great work by Alice Sun and @ckcding
nature.com/articles/s4141…
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Our new review paper on MESH1 and its striking similarities with bacterial SpoT and stringent response.
#PLOSPathogens: From magic spot ppGpp to MESH1: Stringent response from bacteria to metazoa dx.plos.org/10.1371/journa…
@DukeMGM. Some striking similarities here.
[THREAD]
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@DrewWhite9 @FahyTed @BrentDyer3 @DrRobDavidson @drsimonegold we have been working on RBC transcriptome for a long time. Most of the RBC RNAs are small-sized microRNAs. But there are also significant levels of mRNAs and other larger RNA species that underwent dramatic changes during storage.
onlinelibrary.wiley.com/doi/10.1111/bj…
frontiersin.org/articles/10.33…
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The danger of the disinformation of @drsimonegold:
Pediatric patient in our hospital in dire need of a blood transfusion. Parent refused because there might be mRNA in the blood. Being vague for HIPAA reasons, but this is how disinformation harms innocent people.
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Women Physician-Scientists at UCSF@MDPhDEquity
congrats to @KotasMaya and @RnaHelix - two @UCSF #physicianscientists (and WPSS members) selected for the 2022 Burroughs Wellcome Fund Career Awards for Medical Scientists!! 🥂 #bwfcams @UCSFPath @UCSFMedicine @UCSFPCCMFellows congrats to all of the awardees!
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Jen-Tsan Ashley Chi retweetledi
Our featured publication investigates the effects a low-carb diet could have on patients with prostate cancer: ow.ly/2mqo50IC1Ss
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Jen-Tsan Ashley Chi retweetledi
Our newest featured publication highlights work from @TsanJen, Simon Gregory & team on gene expression regulation and heterogeneity among red blood cells: ow.ly/yfkT50J6mlq
@DukeMGM
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Heart is heavy today. Michael Brodsky loved spending time with his family & friends, good food, Clint Eastwood movies, & most of all his granddaughter’s laughter. He treated everyone he met w/ dignity & respect, & taught me the value of responsibility & hard work. RIP Dad.💔😢
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Jen-Tsan Ashley Chi retweetledi
You ask me how you can help #Ukraine
Please, help Ukrainian army & share the info.
National Bank of Ukraine today opened Special Account to raise funds for Ukraine’s Armed Forces
It’s official. The details are on NBU website bank.gov.ua/en/news/all/na…
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Jen-Tsan Ashley Chi retweetledi
Felt a little emotional when the #Taipei skies darkened and the top of #Taipei101, #Taiwan’s tallest building lit up. The tower’s colours change every day. Tonight #Taiwan stands with #Ukraine
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Jen-Tsan Ashley Chi retweetledi
Jen-Tsan Ashley Chi retweetledi
Important new initiative @DukeMedSchool and @DukeU. Excited to be part of these efforts to cultivate and celebrate excellence and diversity in #STEM
Duke Next Generation Leaders@DukeLeaders
Excited to announce our new initiative @DukeU, the Next Generation Leaders. We aim to bring together cohorts of talented postdoctoral scientists and provide mentoring on academic faculty careers. Please follow us for more information in the coming days, weeks, and months! (1/6)
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Jen-Tsan Ashley Chi retweetledi
It's still early, but the academic job market for positions starting in 2022 looks like it may rebound compared to the very poor pandemic-thinned market last year, based on this cumulative job posting chart made by Juan Pablo Maianti via the @Chemjobber aggregator.
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