J. Tushir-Singh, Ph.D.

Please join us on April 3 for our inaugural symposium entitled "Breaking Boundaries - From Discovery to Intervention: Charting the Journey from Basic Science to Biotech Breakthroughs"! Register now: tinyurl.com/UCDBreakingBou…

"If you keep your nose down in life and keep working, anything is possible." - Curt Cignetti Unbelievable story of confidence, simplicity and success!

@OvCaAcademy Thanks for posting

OCA ECI alum @TushirSingh_Lab shows that, unlike in macaques, human TIGIT isn't cleaved into a soluble decoy. This may explain why TIGIT antibodies have struggled in clinical trials. Read all about it below: doi.org/10.1016/j.jbc.…

A shot in the dark by our lab to potentially explain species-specific differences and the complexity of the TIGIT signaling pathway, and the colossal clinical failure of TIGIT antibodies. This work was led by two UCDAVIS Undergrads, NOT by PhDs or Postdocs health.ucdavis.edu/news/headlines…

A gene therapy targeting X chromosome silencing has shown potential to reactivate healthy MECP2 genes in #RettSyndrome models, improving symptoms and offering hope for X-linked disorders. @NatureComms doi.org/g9tww8 medicalxpress.com/news/2025-07-c…

A single genetic mutation may have made humans more vulnerable to cancer than chimpanzees @UCDavisHealth health.ucdavis.edu/news/headlines…

Humans are more cancer-prone than primates despite over 98% genomic similarity. A FasL mutation unique to humans allows plasmin in solid tumors to weaken immune attack @NatureComms * . Could blocking it boost immunotherapy?

*NEW Paper ALERT* Our new work in @NatureComms on FasL-mediated cancer cell death regulation has revealed that evolutionary substitutions (humans vs. primates) in the FasL extracellular domain render human FasL differentially susceptible to plasmin protease cleavage, a key metastatic protease involved in the metastasis of almost all solid tumors including ovarian cancer ascites, etc. Our findings explain the lower cancer incidence in primates (vs. humans) and also the deep mechanistic reasoning behind the potentially less successful outcome of T and CAR-T based immunotherapies against metastatic solid tumors (vs. leukemia, etc). Congratulations to Wamba E, Mondal et al., and all other authors and collaborators @plegembre @carterra_bio (Dan Bedinger) @UCDavisMedCntr @UCD_Cancer @UCD_MMI The manuscript can be found here: nature.com/articles/s4146…

@NDFootball It will be ND vs Texas championship game

IRISH WIN THE 2025 ORANGE BOWL #GoIrish

@historyinmemes Dogs are million fold more loyal than humans. Its true. I love my dog.

This is the final photograph taken of Hachiko, a Japanese Akita dog renowned for his unwavering loyalty to his owner. Hachiko belonged to Professor Eizaburo Ueno, who resided in Shibuya and taught at Tokyo Imperial University in the early 1920s. Each day, Ueno would walk to Shibuya station accompanied by Hachiko, and they would commute together to his workplace by train. At precisely 3 pm, Ueno would return to the station to head back home, and Hachiko would always be there, patiently waiting to join the professor on their journey. However, one day, tragedy struck when Ueno suffered a stroke and never made it to the station. Undeterred by his master's absence, Hachiko faithfully went to the station every day for nine years until his passing in 1935. To honor his remarkable loyalty, a statue of Hachiko was erected outside Shibuya station in Tokyo. In 2015, on the faithful dog's 80th death anniversary, another statue of Hachiko was unveiled at Tokyo University, symbolically reuniting him with his beloved master, Professor Ueno.

@NBCOlympics This was amazing comeback…wow,!

Femke Bol is UNREAL. 😲 She takes GOLD for the Netherlands in the mixed 4x400m relay with a STELLAR 47.93s anchor leg. #ParisOlympics 📺: NBC, USA Network & Peacock

@AMAZlNGNATURE Make sense that more good things underwent positive selection in chimpanzee evolution than in human evolution :)

Mama chimp beats her kid for throwing rocks at people

Check out our new collaboration with @RoseEDixon1 from @ucd_physiology in @PNAS (pnas.org/doi/10.1073/pn…). We observed two modalities of beat-to-beat ATP fluctuations in ventricular myocytes based on SR-mitochondrial coupling strength. (1/2)

Love ovarian cancer? Hate ovarian cancer? You’re not alone! Submit your abstracts to the Biennial Rivkin-AACR Ovarian Cancer Research symposium! This will be a fantastic meeting with the latest and greatest in ovarian cancer research. myemail-api.constantcontact.com/Abstracts-due-…

Our Lab Group! Pic after @UCD_MMI Friday afternoon Research Forum, Great little presentation by Elvis for your lab.

Professor Brian Kobilka delivering the keynote presentation during the 2024 Ed Krebs Symposium @UCDavisMed @UCDBMM

@theNASciences @UMassChan Many Many Congratulations!!! Phil @zamore_lab Well deserved!

Congratulations Phillip Zamore of @UMassChan, newly inducted #NASmember! #NAS161 #genetics #medicine

@TsolisRenee @abaumler Congratulations!!! @abaumler Great looking couple pic!

Cheering on @abaumler during his induction as a new NAS member #NAS161