ITMAT

Characterizing high resolution structures of #Redondovirus Rep proteins doi.org/10.1371/journa… #Virology #InfectiousDisease #TranslationalScience

Leveraging #Polymorphism data as reliable proxy to map mutation patterns across 108 #Eukaryotic species pnas.org/doi/10.1073/pn… @bvoight28 #Methylation #CpG #GxEinteraction #TranslationalScience

Age-related inhibition of #GutBrainSignaling reduces hippocampal activity and impairs #MemoryEncoding doi.org/10.1038/s41586… #Aging #Microbiome #TranslationalScience

Leveraging #ComputationalBiology at scale to individualize #Immunotherapy: nature.com/articles/s4155… @JoeFraietta @carlhjune #CARTcelltherapy #CellTherapy #CARTCell #TranslationalScience

Charting a course toward meaningful #AIliteracy in #PediatricCaregiving doi.org/10.1542/peds.2… #AI #MediaLiteracy #GenerativeArtificialIntelligence #TranslationalScience

Optimizing #CRISPR for #FunctionalGenomics in patient-derived #Xenograft and primary #AcuteMyeloidLeukemia w/ diverse #PathogenicMutations doi.org/10.1016/j.molc… @junwei_s #AML #TranslationalScience

Novel insight into where the #Neanderthal DNA that persists in people today comes from: science.org/doi/10.1126/sc… @SarahTishkoff #PaleoGenomics #EvolutionaryBiology #TranslationalScience

Reimagining scientific communication using art as a tool for the next generation of translational scientists doi.org/10.1017/cts.20… @CarstenSkarke #ITMATEd #ScienceCommunication #SciComm #SciArt #WorkforceDevelopment #TranslationalScience

#Tryptophan supplementation may attenuate #Naproxen adverse effects and widen its #TherapeuticIndex nature.com/articles/s4146… @FitzGerald__Lab #Pharmacology #DrugMechanism #DrugSafety #TranslationalScience

#Drosophila model updates our understanding of brain–periphery interactions: nature.com/articles/s4158… @amitaseh #BrainHealth #Neurobiology #SleepResearch #Neuroscience #TranslationalScience

Revising the model for #SurfactantProteinC maturation: doi.org/10.1016/j.jbc.… #PulmonaryFibrosis #CellBiology #ProteinTrafficking #AT2Cells #LungDisease #TranslationalScience

#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/view/… #BromodomainContainingProtein4 #TranslationalScience

#1 in Medical Breakthroughs: Seven of the top 20 papers honored by the Clinical Research Forum (CRF) are from Penn @CRForumUS #TranslationalScience

#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome jci.org/articles/view/… @FitzGerald__Lab #TranslationalScience

Can #BrownAdipose tissue be activated for therapeutic benefit in #MetabolicDisease? Possibly by harnessing cell-autonomous pathways: doi.org/10.1016/j.molm… @BaurLab #TranslationalScience

How your neighborhood modulates genetically determined disease risk jamanetwork.com/journals/jamac… #HypertrophicCardiomyopathy #HCM #TranslationalScience

Regulating acetyl-CoA levels through Acetyl-CoA Synthetase 2 emerges as potential safeguard for #CognitiveFunction pnas.org/doi/10.1073/pn… #ACSS2 #Neurodegeneration #Tauopathy #TranslationalScience

Need to consider pharmacokinetic & -dynamic properties & patient-specific risk factors when comparing the cardiovascular risk associated with specific #NSAIDs ahajournals.org/doi/epub/10.11… @ktheken @TiloGrosser #TranslationalScience

Happy New Year from ITMAT!