Dévina C. Ung
907 posts
@UngDevinaC
Postdoctoral researcher in Neurogenetics @iBrain Inserm U1253. Former Postdoctoral fellow at Seaver Autism Center for research at Mount Sinai @Derubeislab
Sharing today the latest from our lab, just published in 𝙉𝙖𝙩𝙪𝙧𝙚 𝘽𝙞𝙤𝙢𝙚𝙙𝙞𝙘𝙖𝙡 𝙀𝙣𝙜𝙞𝙣𝙚𝙚𝙧𝙞𝙣𝙜. As stem cell–based neural models gain traction for disease modeling and drug testing, one of the major bottlenecks has been scaling up production. In work led by Yuki Miura and Genta Narazaki, we present a simple and cost-effective way to prevent neural organoid fusion that allows scalable generation of cortical organoids without compromising quality. In brief, this is done by simply adding the cheap food additive xantham gum! This enabled a single experimenter to screen all FDA-approved drugs for neuropsychiatric disorders across 2,400 organoids, identifying compounds that impair human cortical development. Hoping that will be one more step toward scalable human models for brain development and drug discovery. #Organoids #StemCells #DrugScreening #Neurodevelopment #TranslationalResearch
