Università di Pavia retweetledi

Using patient-derived spinal cord and cerebral organoids, as well as single-cell transcriptomics, researchers discovered that Survival Motor Neuron (SMN) deficiency disrupts the splicing of key genes involved in neural differentiation, potentially triggering spinal muscular atrophy pathogenesis. They also demonstrated that timely therapeutic intervention that increases SMN levels can rescue key pathological dysfunctions. In @NatureComms nature.com/articles/s4146…
@IreneFaravelli, @tmonica86, @IlliaSimutin, @lisa_mapelli, @Chiacordi, @EleonoraPali, @CortiStefania, & others. @DBBS_UNIPV, @unipv, @Columbia, @CentDinoFerrari, @policlinicoMI, @humantechnopole, & @IstTumori.

English



























