Utah Sleep and Circadian Physiology Lab

I gave a TED-style talk at University of Utah #Vitae2026 event discussing the science of sleep and #metabolism, and my scientific journey. @CofHealth @UUHSResearch #UofUResearch #sleep #circadian Watch here: m.youtube.com/watch?v=q0TiUn…

@leif @sleepdiplomat County level self-report data from CDC. “Diet” assessed by food insecurity. Intriguing analyses but also some major limitations, as noted by authors

@leif @sleepdiplomat academic.oup.com/sleepadvances/…

A recent study reveals sleep deprivation is a stronger predictor of lifespan than poor diet or lack of exercise. Sleeping ≤6 hours reduces lifespan by 13%. Prioritize sleep; it's a non-negotiable biological necessity. #SleepScience #Longevity

🌞 Light timing matters, and so do individual differences. A new study shows circadian effects depend on when you get light and how sensitive your clock is. Evening light can delay timing; daytime light supports proper alignment. @circadianumbers journals.sagepub.com/doi/10.1177/07…

Importantly though, in REWIND trial of dulaglutide vs placebo, the CI was 0.79-0.99 for CV outcomes. Upper bound reaching 1.0 (unity) versus placebo and thus the non-inferiority findings here for tirzepatide vs dulaglutide should not be over interpreted for benefit. True real world effect outside the RCTs is likely to be smaller

Noninferiority trial of tirzepatide (dual agonist for GLP1 and GIP) vs dulaglutide (single agonist GLP1) for cardiovascular outcomes in people with diabetes and atherosclerotic CVD nejm.org/doi/full/10.10…

When your PI presents your work

Join us for #AskMeAnything with Editors in Chief Drs. Allan Pack (SLEEP) and Sean Drummond (SLEEPAdvances). Send us your questions by adding a comment below. The Editors in Chief will be responding to all your questions on January 5th!

Sarcopenia is real, and important in many elderly. The exaggeration’s and misinformation surrounding i)the magnitude of the problem and ii)benefits of unproven solutions in the context of GLP-1 medicines are also real. Keep calm, carry on, and remain data driven #weightlloss

Unambiguous (disappointing) results for oral semaglutide in the evoke trials. No impact on progressive deterioration of cognitive function #AlzheimersDisease sciencehub.novonordisk.com/congresses/cta…

I participated in this several years ago and found it quite helpful both for writing peer reviews and for improving my own grant writing

The process

In this case the editorial team pre-selected the two trial manuscripts, it would be great to see this done with blinding. Go back to past 3 years of submitted manuscripts and have LLM make decision to send out for peer review or not….what is concordance with editors?

@nejmunofficial using #AI (LLM) to expedited peer review. Will be interesting to follow how this evolves, given the well-established issues with current peer review system. 1. Will this perpetuate current bias in publication system or could we leverage it for enhanced peer review? 2. A full RCT of AI vs human peer review could be interesting, but just one small piece of a larger puzzle 3. Anecdotally I see vast variability in peer reviews, can we use LLMs to score/critique the quality of peer review? And editorial decisions? ai.nejm.org/doi/full/10.10…

The first rule of Data Science - if your p-value is less than 1 over the number of atoms in the universe, you're using the wrong model.

More commentary on the #churnalism around #melatonin and #heartfailure from @Sensible__Med. A widespread issue that needs constant focus open.substack.com/pub/sensibleme…