University of Utah Pain Medicine

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University of Utah Pain Medicine

University of Utah Pain Medicine

@UofUtahPain

Advancing the field of pain medicine through interdisciplinary and innovative clinical care, education and research. #UofUPainMedicine

Salt Lake City, UT Katılım Aralık 2018
271 Takip Edilen518 Takipçiler
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Michael Okun
Michael Okun@MichaelOkun·
Boom! Cerebrospinal fluid (CSF) flow extends to peripheral nerves. Alexander Ligocki, Ed Scott and colleagues @UF @UFHealth blow our minds. New paper @ScienceAdvances. What will we call it now? Cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Just when you think you have a few ground truths of the brain and nervous system, you are humbled again. Key Points: - The authors point out that dogma holds that cerebrospinal fluid is responsible for 'maintaining brain homeostasis through nutrient delivery and waste removal for only the central nervous system.' - They show extensive CSF flow throughout the peripheral nervous system. - They traced multimodal 1.9-nanometer gold nanoparticles. - These nanoparticles were roughly the size of CSF circulating proteins. - They squirted them into the lateral cerebral ventricle. -They showed incredibly that the particles transitioned from central to peripheral nervous systems at root attachments and transition zones. - They showed the particles could make it all the way to the axoplasm of distal peripheral nerves. - Bigger 15-nanometer gold particles were not able to make the journey. My take: We know that the nervous system does not contain the more traditional lymphatics and has a force field called the blood brain barrier. We know that CSF delivers nutrients and removes waste from the brain and central nervous system. Our previous ground truth was established by studies using dye tracers. Using small gold nanoparticles these authors 'tore down the dogma.' So the real question is whether it is time for a name change? Cerebrospinal fluid (CSF) or cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Thoughts? Sartor resartus – the tailor re-tailored our view on this important aspect of neuroscience. BRAVO! science.org/doi/10.1126/sc… #parkinson #CSF #cerebrospinal #Alzheimers
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Shane Brogan
Shane Brogan@ShaneBrogan9·
Fun and interactive audience at #ins2024 Lots of great discussion and questions about intrathecal drug delivery in #CancerPain Thank you @IntlNeuromod for putting IDD in the spotlight
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University of Utah Pain Medicine
Thanks to Pain Medicine Fellow, Marco Uribe, MD for teaching us more about Arachnoiditis, and Yoshio Nakamura, PhD for sharing his lecture, "Making sense of bio-pyscho-social approach, psychadelic-assisted therapy, placebos, and nondual awareness: An enaction approach" this a.m.!
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Newaj Abdullah, MD (he/him/his)
Newaj Abdullah, MD (he/him/his)@AbdullahNewaj·
Cervical SCS for post-herpetic neuralgia in the V1 distribution by targeting nucleus caudalis. Thank you, Shervin, for your guidance. It is always a pleasure to work with my mentee — Dr. Gill. @rshervin @benjamin_gill @UofUtahPain
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