Vincent Rotello
187 posts
Vincent Rotello retweetledi
The more humans evolve, the more data to store. Our capabilities are limited. The best example we can get inspired from is #nature & the storage of our #genetic information. #DNA is probably an amazing key for the future of #datastorage. @sciam scientificamerican.com/article/dna-da…
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Vincent Rotello retweetledi
In order to prevent our infection to #COVID-19 via our hands, we use #hand #sanitizer. However, it is also a risk: high levels of #acetaldehyde in some #alcohol-based hand rubs exceed relaxed #regulations…Be careful! @cenmag ow.ly/Gw4N50ECRuC Photo credit: Shutterstock
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A sweet solution to a really challenging pathogen
Bioconjugate Chem@BioconjChem
#Fungal infections are more than just a bother, and yeast infections are an extremely prevalent variety. Martin et al. found promising avenues of application for potential #Candida #yeast inhibitor #glycomimetic 1. @MaynoothUni @UGrenobleAlpes pubs.acs.org/doi/10.1021/ac…
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Some of the most challenging synthesis out there!
Chem Soc Rev@ChemSocRev
Check out 'Classic highlights in porphyrin and porphyrinoid total synthesis and biosynthesis' by Mathias Senge @mathiassenge, Natalia Sergeeva & Karl Hale below #openaccess @TCD_Chemistry @QUBCCE @chemleedsuni 🔓 👇 xlink.rsc.org/?doi=C7CS00719A
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Reducing stress is a good thing!
Bioconjugate Chem@BioconjChem
#TEMPO is an #antioxidant used to reduce oxidative #stress, but it has low solubility & undergoes rapid #renal clearance! @Duvall_Lab_VU fascinatingly optimized TEMPO to enhance its reactive #oxygen species scavenging & #bioavailabilitly in vivo. ow.ly/ooV750Evx0v
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Really nice technique for quantifying a really useful LEGO block
Bioconjugate Chem@BioconjChem
#Biotinylation of #proteins is very useful, but determining biotin incorporation in a #bioconjugate is strenuous due to steric effects. Read how Ogle et al @unccharlotte efficiently quantified biotinylation using a water-soluble isatoic anhydride platform. ow.ly/AHcB50EvwMQ
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Vincent Rotello retweetledi
#Growth Factors, so useful & readily available straight from our cells, yet so hard to contain and sustain for long enough to aid us. If you know the struggle, perhaps @thechowlab's new publication on how to combat those faults are worth a look? @LehighU pubs.acs.org/doi/10.1021/ac…
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But sometimes we can teach!
Irshad Hussain@DrIrshadSadhana
There’s no need to argue with a person who doesn’t know that he/she doesn’t know.
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Vincent Rotello retweetledi
We hear about #virus everywhere - some may help in #Nanomedicine! Look at this #Protein-Engineered Cowpea Chlorotic Mottle Virus-Like #Particles! A little bit of cooking & you prepare a #dual #site-selective configuration at their #surface. @vanhest_lab
pubs.acs.org/doi/10.1021/ac…
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Mystery solved!
Bioconjugate Chem@BioconjChem
No time like the #present to solve a #mystery! #Halotags have had strange blips of #protein bands that don't fit the literature & only in the latest @BioconjChem publication did an answer & remedy get revealed out of lab of @ChemKritzer @TuftsUniversity. pubs.acs.org/doi/10.1021/ac…
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The next generation materials for medical devices.
Bioconjugate Chem@BioconjChem
#Medical #patches are powerful tools for wound healing, #infection treatment and #tissue #engineering. In this review, learn about recent advances in functional #biomaterials & how it shaped the advances in manufacturing & applications of medical patches. ow.ly/JU1Q50EukH4
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Vincent Rotello retweetledi
Protein delivery is great, #intracellular #protein #delivery is greater! This #challenge is faced by Futaki et al. Prepare a #conjugate of HAad #peptide with #pyrene butyric acid as a #membrane-anchoring unit - see what happens! #Cytosolic #translocation? ow.ly/6HhM50Es5aU
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Definitely an emerging topic!
Bioconjugate Chem@BioconjChem
You've heard of #apoptosis but how about #ferroptosis? @acsnano explores the mechanism of this novel #cancer treatment and explores the role of exogenously applied heat stress, with the ultimate goal of killing #tumors by inducing #lipid #peroxidation. ow.ly/VROo50EtaJV
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Vincent Rotello retweetledi
In this review by Huang, Luther et al., approaches to functionalize nanoparticles with “small” organic ligands are discussed, providing insights into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.
Read more here:
doi.org/10.3390/nano11…
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An excellent review for structural biologists solving hard problems
Bioconjugate Chem@BioconjChem
In this review, Fauser et al. look at the #biochemical methodologies for covalent stabilization of #macromolecular #complexes enabling structural investigation via crystallography, NMR, cryo-EM. ow.ly/Now950Es5WW
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Vincent Rotello retweetledi
We're proud to announce that our manuscript on tandem-cleavage linkers ow.ly/Kruq50EjSyI was accepted for publication in @BioconjChem. Click to learn how SMARTag® played a role in improving the stability and tolerability of ADCs and how it could improve patient outcomes.
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Awesome talk, actually!
The Rotello Group@RotelloGroup
David Luther presenting at the Spring 2021 CBI Chalk Talk. Great work!
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