Shouhong Guang

I am really honored for this. This would not be possible without the hard work of my trainees, guidance by mentors including Joan and Ron Conaway @UTSWMedCenter , @kaelin_lab, David Stern, and Jeff Sklar, and support of my colleagues @yalepathology @YaleMed @Yale, and my family.

Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans biorxiv.org/content/10.648…

Heat stress-induced condensation of G3BP1 in perinuclear P-bodies in C. elegans' germline biorxiv.org/content/10.648…

rdcu.be/eRT2i The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription machinery to initiate piRNA expression within heterochromatic clusters

NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors: Cell Genomics cell.com/cell-genomics/…

TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans sciengine.com/SCLS/doi/10.10… via @https://www.sciengine.com

rRNA intermediates dictate nucleolar architecture in C. elegans biorxiv.org/content/10.110…

piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation nature.com/articles/s4159…

rdcu.be/ey2RV Comprehensive profiling of the catalytic conformations of human Guanylate kinase

pmc.ncbi.nlm.nih.gov/articles/PMC12… Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation

Nucleolar proteomics revealed the regulation of RNA exosome localization by MTR4 - Molecular & Cellular Proteomics mcponline.org/article/S1535-…

Nuage in color: Systematic protein tagging shows the compositional complexity of germ granules: Developmental Cell cell.com/developmental-…

The transcription machinery of piRNAs in worms and flies are quite similar. Both of them need an epigenetic reader and somehow recruits special transcription factor. worms: USTC -> UAD-2 -> TAF-12 flies: (kipferl)-> Rhino ->RDC -> moonshiner

The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA expression within heterochromatic clusters biorxiv.org/content/10.110…

Happy Chinese New Year.

NRDE-3 formed peri-centrosomal foci neighboring the tubulin protein TBB-2, other centriole proteins and pericentriolar material (PCM) components in C. elegans embryos.

Peri-centrosomal localization of small interfering RNAs in <?A3B2 pi6?><italic>C</italic>. <italic>elegans</italic> sciengine.com/SCLS/doi/10.10… via @https://www.sciengine.com

The discovery of tiny RNAs that have crucial roles sciengine.com/SCLS/doi/10.10… via @https://www.sciengine.com

Most importantly, all the labeled strains are deposited in CGC.

Compartmentalized localization of perinuclear proteins within germ granules in C. elegans: Developmental Cell cell.com/developmental-…

We identified a new D granule. The proteins that participate in distinct piRNA processing steps were localized in particular subcompartments, including the P-, Z-, and E-granules.