Thiago Wendt Viola

We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood from newborns with and without cocaine exposure during pregnancy. We used DNAm data to (1) assess pediatric epigenetic clocks at birth and (2) to estimate epigenetic scores (ES) considering the large-scale DNAm data availability and existing evidence regarding prenatal cocaine exposure (PCE) as a risk for health problems later in life. We generated ES for tobacco smoking, psychosis, autism, diabetes, and obesity. PCE was associated with protracted DNAm gestational age in newborns, and this effect remained significant when controlling for potential confounders, such as blood cell type composition predicted by DNAm and obstetric data. DNAmGA was negatively correlated with BDNF levels in the serum of UCB. Higher tobacco smoking, psychosis, and diabetes ES were found in the PCE group. The GO analysis revealed GABAergic synapses as a potential pathway altered by PCE. @WViolaThiago @FriesGabriel nature.com/articles/s4159…

@grassirod @DFF_raad Congratulations!!!

I am glad to announce it is official! We got the Better Framework for Psychiatry @DFF_raad grant! I can only think about I Ching Hexagram 53, Ji’an: “The best progress is slow but steady—slow enough to allow for bonds to knit properly and steady enough to keep moving in the right direction. A firmly rooted tree has deep roots and is not easily toppled.” Thanks Chioma Okeoma (NYMC), Chelo Walss-Bass (UTHealth) and @WViolaThiago (PUCRS) for the partnership!

The most relevant predictors included drug-use behavior history, but also features related to childhood maltreatment exposure and psychiatric comorbidities.

By using machine learning we found clinical and psychosocial variables that can be assessed in real-world clinical settings, potentially helping clinicians to identify individuals with severe cocaine withdrawal that is likely to be sustained over the course of detoxification.

Cocaine use disorder effects on blood oxytocin levels and OXTR DNAm sciencedirect.com/science/articl…

Exploring the impact of early life stress on transcriptional changes in the mPFC 📊🧠 at @FeSBE

Nanopore sequencing!! @grassirod @Paul_R_Marshall @BernardoHeberle

@The_Gilp Lol

Having a good time with friends!

Presenting at NIDA genetics and epigenetics meeting a poster on how maternal cocaine use affects pediatric epigenetic clocks of early maturatipn and methylation risk scores for distinct outcomes later in life.

@Paul_R_Marshall @grassirod @KerstinCr @MarcoRivaLab1 Thank you my friend!!

@WViolaThiago @grassirod @KerstinCr @MarcoRivaLab1 Love this! Nice work all!

Our new meta-analysis demonstrates that rodent animals exposed to prenatal or postnatal stress, showed a significant increase in microglia density, decreased oligodendrocyte density, and an increase in microglia soma size. sciencedirect.com/science/articl…

@e_brietzke Christian Grey

Me sugira um personagem e eu te respondo com uma historinha que cabe num tuíte.

@Paul_R_Marshall @JCSMR Congratulations!!!

My lab will be opening in April 2023 at @JCSMR. Excited to be surrounded by amazing colleagues in a top notch environment. We will continue work on DNA structure and modifications in the context of memory stability, and more! Please DM if interested, have open positions/projects

Our findings suggest a clear oxidative imbalance in persons with SUD, which could lead to cell damage and result in multiple associated comorbidities, particularly accelerated aging. onlinelibrary.wiley.com/doi/full/10.11…

@The_Gilp Hahahahaha

@The_Gilp compulsive behavior despite adverse consequences

@XiangLi_WHU Congratulations!!

Just received the NoA of our 3rd project grant @ NSFC, which will focus on studying at the intersection of RNA modification & memory consolidation. 😇