Walczak Lab

We're thrilled to share our new @J_A_C_S publication revealing how N-glycosylation shapes tau protein behavior. Check it out at pubs.acs.org/doi/10.1021/ja…

A warm welcome to the first-year graduate students joining the Walczak lab - Himanshu, Zachary, Tania, Cat, Lily and Antawn!

We’re excited to share that our latest paper is officially published in its final form at @ACSCentSci! Huge thanks to everyone involved in making this work possible. pubs.acs.org/doi/10.1021/ac…

@Sumit_glycan @J_A_C_S @i_am_santosh Thank you, Sumit!

@WalczakLab @J_A_C_S @i_am_santosh Congratulations to the team 💐💐

A new paper in @J_A_C_S describing the synthesis of Si-linked glycomimetics. Congratulations to @i_am_santosh, Timmy, Nick and Kyle! pubs.acs.org/doi/10.1021/ja…

@samuccen @J_A_C_S @i_am_santosh Thank you, Sam!

Congratulations Kyle Fisch for receiving the NSF GRFP! Excited for the discoveries and impact you'll make in grad school and beyond. @CUBoulder @CUBoulderCHEM

@BrimbleM @Boron_Chemistry @DrH_aucklanduni @JOC_OL Thank you for the swift and efficient editorial process at Organic Letters! It was a pleasure contributing to the journal.

@Boron_Chemistry @DrH_aucklanduni @JOC_OL @WalczakLab Thanks for submitting this nice work to Organic Letters!

Peptide and Protein Desulfurization with Diboron Reagents (@JOC_OL): pubs.acs.org/doi/10.1021/ac… (@WalczakLab).

Our group's latest research on tetrahydroxydiboron-mediated reactions in peptide/protein chemistry is now published in @JOC_OL. A huge congrats to @Jing_Ruiheng! pubs.acs.org/doi/10.1021/ac…

A new pre-print from our lab available on @biorxivpreprint Post-Translational Modifications Control Phase Transitions of Tau biorxiv.org/content/10.110…

Happy New Year from everyone at the Walczak Lab! Wishing you all a year of prosperity, both professionally and personally. 🥳🎉🥳

Only two weeks left to apply to our graduate program at @CUBoulderCHEM! colorado.edu/chemistry/grad…

@huang_shaofeng @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Thanks, Shaofeng!

@WalczakLab @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Congratulations Ruiheng!

We're excited to reveal our latest study on desulfurative borylation in @J_A_C_S ! Congrats to @Jing_Ruiheng, @wyattpowel87711, and Kyle! doi.org/10.1021/jacs.3…

@ShahmoraLab @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Thanks Sarah!

@WalczakLab @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Very exciting!! Congratulations to you all!!

@weizhangCU @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Thanks, Wei!

@WalczakLab @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Congrats, Ruiheng, Maciej and the team!

@AhmadMasarwa2 @JbaraM90 @J_A_C_S @Jing_Ruiheng @wyattpowel87711 Thank you, Mhmad!

@WalczakLab @JbaraM90 @J_A_C_S @Jing_Ruiheng @wyattpowel87711 What a wonderful work! Congrats.

Stay tuned as we unveil more results and delve into intricate mechanistic studies.

Tau undergoes extensive post-translational modifications, but what truly stands out is the contrasting expression of these modifications in healthy and Alzheimer's afflicted brains. 🧠💡

Today we report in @J_A_C_S the first chemical synthesis of microtubule-associated protein tau. Congratulations to @wyattpowel87711 and @Jing_Ruiheng on this monumental accomplishment. 🎉👏 #TauSynthesis 1/n doi.org/10.1021/jacs.3…

Our approach to investigate PTMs in tau revolves around chemical synthesis. We successfully combined 11 distinct fragments through a sequence of highly efficient ligations to produce the longest 2N4R isoform.