WARREN MICHAEL HOLMES

SAW PALMETTO: The Natural DHT Blocker Your hair is thinning and you don’t want the prescription stuff with the horrific side effects ? Saw palmetto is the plant extract that gently fights DHT - the hormone shrinking your follicles. Take 320 mg a day (standardized extract). Here’s what real studies on regular men show: • Less hair falling out (one trial saw 29% drop in shedding) • Thicker feel and more density after 4 months • Some guys got noticeable regrowth, especially on the crown It’s milder than finasteride (works for about 38% of men vs 68% on the pill in head-to-head tests), but way easier on the body with almost zero sides.

KETOCONAZOLE SHAMPOO HACK 
Use it 2-3 times a week instead of regular shampoo. Must leave the shampoo on for minimum two mins (massage it into the scalp) 
Fights scalp inflammation and mild DHT. 
Pairs perfectly with minoxidil. 
Many guys report thicker hair just from switching.

COLLAGEN IS A GAME-CHANGER FOR HAIR 
We lose 1% collagen every year after 20. 
That means thinner hair and weaker roots.
 Side effects of taking collagen? • Hair grows thicker • Less shedding in the shower • Stronger nails too
 Take 10-20g a day.

Simple Daily Stack for Thicker Hair : 
Collagen - 10-20g after workout → hair grows stronger. 
Omega-3 fish oil - 2g with food → less scalp inflammation. 
Pumpkin seed oil - 400mg morning → blocks DHT gently. 
Take these 3 every day. Studies show men keep more hair and even regrow some.

HAIR LOSS BIOHACK CHEAT SHEET #2: Evidence-Based DHT Blockers (Natural)
 Pumpkin seed oil (PSO): 2014 RCT (Evid Based Complement Alternat Med) - 400 mg/day oral x 24 weeks → +40% mean hair count vs. +10% placebo (p<0.001) via beta-sitosterol 5AR inhibition. Saw palmetto: 320 mg/day standardized extract shows ~60% similar efficacy to finasteride in head-to-head (smaller trials).

HAIR LOSS BIOHACK CHEAT SHEET #1: Androgenetic Alopecia (AGA) Pathophysiology 
The root cause isn’t just “genetics” - it’s DHT binding androgen receptors in susceptible scalp follicles, shortening anagen (growth) phase and miniaturizing them. Per a 2023 review in J Invest Dermatol, DHT sensitivity + inflammation + poor microcirculation = progressive loss. Data: AGA affects 50% men/40% women by age 50; follicle stem cells stay alive but “dormant.” Biohack angle: target 5AR inhibition + anti-inflam + blood flow.

I won. Again. It’s getting embarrassing for @Jim22Palmer now ! ..and even more embarrassing for his lawyer, Amrit Dhaliwal.

This 2023 RCT (Milani et al., Skin Res Technol, n=83 with AGA or TE) is solid data. Adding hydrolyzed marine collagen (300 mg) + taurine, cysteine, methionine, iron & selenium to standard treatments boosted blinded Global Assessment Scores 2.5× higher (1.67 vs 0.66, p<0.001) in 12 weeks - 50% “much improved” vs 23%. Mechanisms hit hard: methionine activates Wnt/β-catenin (follicle cycling), taurine blocks TGF-β1 miniaturization, collagen ↑ dermal papilla proliferation + IGF-1/VEGF, nutrients fix deficiencies. Excellent adjunct. Get labs (ferritin >70, thyroid), layer with minoxidil + dutasteride, track photos.

Hair loss reversal with collagen, taurine, cysteine, methionine, iron, & selenium. Substantially improved hair growth in 3 months with an oral supplement: ‣ Collagen - constitutive amino acids ‣ Methionine - stimulates Wnt/β-catenin pathway ‣ Cysteine / taurine / iron - growth signaling ‣ Selenium - antioxidant, thyroid support regardless of the type of hair loss (androgenic alopecia / telogen effluvium).

Fully functional hair follicles grown in the lab for the first time ! researchers from the US and Japan created follicles that naturally cycle through growth phases, attach to tissue, and regenerate. This moves regenerative medicine from slowing loss to true follicle creation and restoration. Human applications are the next frontier. Secretome therapy is surging as the next-level regenerative play: stem-cell-derived proteins, peptides, and exosomes reactivate dormant follicles with faster, longer-lasting results and zero downtime.

PP405 is the molecule everyone’s watching in the hair space rn An experimental drug (UCLA origins) that directly reactivates dormant hair follicles via a metabolic pathway - fundamentally different from minoxidil, dutasteride or finasteride. Early data shows it “wakes up” sleepy follicles for new growth rather than just slowing loss. Human trials accelerating into 2026. Looks promising

@_alisawu Ugc

introducing Bluma. the all-in-one platform for AI UGC. we’re the first to de-edit videos - breaking them into scenes, captions, and elements automatically. Bluma lets you create winning organic short-form and paid ads with our asset generator and node-based canvas that saves your creative workflows. we allow you to clone winning formats, batch generate assets, and edit videos all in one place. comment “ugc” for free credits and early access to @getBluma! getbluma.com

FDA doesn’t pre-approve most cosmetics. Companies can toss in ingredients like parabens or sulfates without proving they’re safe long-term - only that they’re not blatantly harmful under normal use. The law says products can’t be “adulterated” if they’re dangerous when used as directed, but enforcement’s weak. No mandatory safety testing, no ban lists like Europe’s over one thousand three hundred chemicals. Look at this - US bans just eleven nasty ones, while the EU’s got over thirteen hundred off-limits because of cancer, hormone, or birth defect risks.

Aston Villa should relocate the training ground to London area and sell off Bodymoor Heath. The top players want to live in London. Villa Park stays home. No more excuses like we saw with Conor Gallagher choosing Spurs for London roots. Same for corporate offices - move to London like United did in Mayfair (now Kensington). Best C-suite talent lives there. This 'local living' tradition is outdated nonsense. Look at US sports: separate training/HQ from stadium city. Time to modernize if we want to scale, attract elite talent, and challenge the Big Six financially. Global brand needs global thinking. #AVFC

Without an AI-proof skill, young people are in serious trouble. Fast.

2026 wake-up call: AI is gutting white-collar jobs RIGHT NOW entry-level office roles vanishing, hiring frozen, CEOs bragging they'll slash half their desk workforce in months. Millions of grads staring at extinction. Act FAST or get left behind. But one path is booming & AI-proof: HAIRDRESSING. Hands-on skill robots can't touch 5-7% job growth (faster than average) thru 2034 84K+ openings yearly from demand + turnover Be a round like minded creative young people. Look cool, listen to music, be a part of culture, real human connection. There is no better place to be for a young person than a hair salon, trust me. You can earn money too, if you're good. In 2003 i was taking home £52,000 a year not including all the tips I was getting. I was making 6 figure salary by 20. That was 20 years ago ! I was a millionaire liquid by 29 years of age. And i loved going into work everyday. Still do. Hairdressing is the greatest industry to build a career for a young person, the opportunities are endless. Young people: don't listen to you parents, don't waste your time and money going to college and University. Ditch the doomed desk dream. Grab an apprenticeship NOW & build a future-proof career people will ALWAYS need. Hair doesn't cut itself.

@oliverwhudson Persona

We mapped the full persona-led creative system we run for 8 and 9-figure DTC brands. It's yours. Persona-led creative strategy has been the single biggest topic of conversation in our world over the last 6 months - across our client work, our podcast, our Meta partnership, and the broader DTC community we're part of. The problem is that the conversation has been scattered. A framework here, a podcast episode there, a case study buried in a guide. Brands were getting pieces of the picture but not the full system. So we built this. Everything on this board reflects what we are actively doing right now for the 8 and 9-figure DTC brands we work with - from the AI research stack we use to build personas, to the brief structure, to the testing tiers and optimisation rules we run in accounts every day. It's informed by our own data, our official Meta partnership research, and the conversations we've had with people like Maxime - Meta's Creative Strategist for Disruptor brands - who gave us a rare look at how Andromeda actually works from the inside. A single, chronological walk-through of the full persona-led engine - so you can see not just what to do, but why each step feeds the next. Want it? Retweet this post Comment "persona" and I'll send it over

UP THE VILLA BIRMINGHAM FOREVER

Hair Loss Peptide coming ! GHK-Cu shows mechanistic promise for supporting hair loss. It binds copper ions, upregulates collagen/elastin production, enhances VEGF-mediated angiogenesis to improve nutrient delivery to follicles, and appears to inhibit TGF-β1—which can drive premature catagen transition and miniaturization in androgenetic alopecia. Preclinical data (e.g., ex vivo human follicle models and dermal papilla cell cultures) demonstrate increased follicle elongation and reduced apoptosis. A 2023 review highlighted it as a potent promoter with fewer systemic side effects than finasteride and dutasteride. Topical forms are already accessible but compounded injectables offer higher bioavailability.