Wayne Holman, MD

22 posts

Wayne Holman, MD banner
Wayne Holman, MD

Wayne Holman, MD

@WayneRidgeback

Wayne Holman is the Founder Ridgeback Capital & Co-Founder Ridgeback Biotherapeutics

Miami, FL Katılım Ağustos 2016
215 Takip Edilen325 Takipçiler
Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
@llborio @EmoryMedicine Thanks Dr. Borio. Ridgeback Biotherapeutics is collaborating with George Painter and will be taking this into human studies in the next few days.
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
@WalkerStapleton Thanks Walker. FDA cleared EIDD-2801 to start human trials last Friday. Ridgeback Bio will start trials in a few days.
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
@ScottGottliebMD EIDD-2801 is oral, easy scalable CMC, can be used early in disease at home. Much less expensive manufacturing vs antibodies. Prevents severe disease in animal models of MERS and SARS.
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Scott Gottlieb, MD 🇺🇸
Scott Gottlieb, MD 🇺🇸@ScottGottliebMD·
If antibody drugs are going to provide perhaps our best shot at mitigating future #COVID19 risk and serving as a bridge to a vaccine; manufacturing these drugs at scale is going to be the obstacle. We can get a jump start on this now. Congress provided the funding to do so 2/n
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Scott Gottlieb, MD 🇺🇸
Scott Gottlieb, MD 🇺🇸@ScottGottliebMD·
THREAD: The provision in the CARES Act that provides money to build commercial scale manufacturing pre-approval for the most promising #COVID19 drugs, and enables large scale manufacturing and stockpiling of doses, is critical to our readiness for the second wave in the Fall. 1/n
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
@martinvars Hi Martin, Follow me @WayneRidgeback We have an oral drug for COVID19. FDA cleared us to go into human studies. It prevents severe disease in animals with MERS and SARS. We hope to show the same in humans with COVID19. Happy to see you are well.
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Martin Varsavsky
Martin Varsavsky@martinvars·
As a reminder out of 13,000 deaths only 8 people under 30 have died in Spain the data is here mscbs.gob.es/profesionales/… What Spain should have done is protected those over 65 who are 95% of the deaths.
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Martin Varsavsky
Martin Varsavsky@martinvars·
Isolation has drastically lowered daily deaths in Spain. Now it's time for the govt to review the cruelty with which Spain has treated its children. Every other democracy has let them go out isolated or in groups. Spain has completely locked them down for 22 days.
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
Thanks to Tim Sheahan, Mark Denison, Ralph Baric, George Painter, Wendy Painter for all the great research on EIDD-2801. Human trials to start in days. #COVID19 #CURECOVID
Timothy Sheahan@timothysheahan

Here is our new paper on an oral #antiviral drug that works against #SARSCoV2 #COVID19. A herculean effort w/ Amy Sims @Ardinajp @mariagoneviral @DenisonLab @KDinnon @aschaefe29 @SarahRLeist @Baric_Lab @DenisonLab @knowerofrandom stm.sciencemag.org/content/early/…

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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
Ridgeback to start human testing on EIDD-2801 within days. Oral investigational drug. Animal data in MERS and SARS shows early treatment prevents severe illness. We hope to prove the same in people with COVID-19. #COVID19 #CURECOVID19
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
Questions 1)Is there a relationship between severity of COVID-19 in 30-50 year olds and the exposure to RCCVs from kids through household (parents) and professional (MDs and teachers) contact? 2)Would greater prior exposure the RCCVs result in a milder COVID-19 disease course?
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
8)Prevalence of anti-RCCV antibodies declines with age in older adults 9)Antibodies to the RCCVs, SARS-COV-1 and MERS isolated from human samples can have some cross reactivity to each other
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
6)Adults with children are more frequently infected with the 4 RCCVs relative to adults without children 7)Teachers and pediatricians are more likely to be infected with the 4 RCCVs
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
3)Children are less likely to have severe disease with SARS-COV2 4)Younger kids will have had less exposure to RCCVs vs older kids 5)Within childhood age groups the youngest are more likely to have severe disease
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
Data reported in the medical literature: 1)There are 4 routinely circulating coronaviruses (RCCVs) that cause mild disease 2)Children are more routinely infected vs adults with the 4 RCCVs in published studies of subjects in NYC and China
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Wayne Holman, MD
Wayne Holman, MD@WayneRidgeback·
Flattening the Curve: The South Korean Approach to COVID-19 @stevejang/flattening-the-curve-the-south-korean-approach-to-covid-19-49cb55d1e782" target="_blank" rel="nofollow noopener">medium.com/@stevejang/fla…
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Andy Biotech
Andy Biotech@AndyBiotech·
#COVID19 For those asked what societal responses we can take to flatten the curve for this #coronavirus epidemic, here is an excellent new paper recommended by Dr. Tony Fauci with many actionable low-cost interventions for workplace, household, school, etc papers.ssrn.com/sol3/papers.cf…
Andy Biotech tweet mediaAndy Biotech tweet mediaAndy Biotech tweet mediaAndy Biotech tweet media
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Andy Biotech
Andy Biotech@AndyBiotech·
#COVID19 is neither the end of the world nor #JustTheFlu. It is something that you should take seriously but not panic about. We will get through this #coronavirus crisis, but we need to take swift societal response NOW. Stay calm, be cautious and prepared. Take care and be safe!
Andy Biotech@AndyBiotech

#COVID19 South Korea encouraging sign continues - Daily new case # declines 4 days in a row: 518➡️483➡️367➡️248 - Total cases: 7134➡️7382 - Death toll: 50➡️51 - Sample being tested: 19K➡️17K

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Keşfet

@llborio @EmoryMedicine @WalkerStapleton @ScottGottliebMD @martinvars @elonmusk @BarackObama @taylorswift13