Williams Lab

We are even more excited to share @SCantilena’s PhD work! onlinelibrary.wiley.com/doi/10.1002/ct… As always, amazing work Sandra 🙏 @DBC_ICH

Massive thanks to my team, collaborators and funders! @WilliamsLabUCL @BelaPatel_lab @Yolandacalle @menz_mas @lucacozzuto @LeukUK

What is the clinical significance? #PP2A re-activation già forskolin Is a therapeutic strategy for KMT2A- rearranged #leukemia. Forskolin could be employed to improve the therapeutic index and tolerability of standard #chemotherapy daunorubicin

What does this study add? A comprehensive characterisation of #PP2A in over 300 AML #leukemia samples, a toxic effect of forskolin in leukemic cells with a repressive effect on C-MYC, HOXA9 and HOXA10 and unanticipated PP2A- independent sensitising activity to #chemotherapy

What is already known? Previous research identified #PP2A as a therapeutic target for acute myeloid #leukaemia and forskolin as a natural compound with anti-#Cancer effects

Very proud to share the recent results of our @LeukUK funded research Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia share.google/1tPM3CFPvmvkBt… @UniOfSurrey @BrJPharmacol

Great opportunity to understand more on how to use oganoids to study diseases @GerliLab the-scientist.com/studying-organ…

A model of a membrane called the blood–brain barrier could transform how scientists study drug delivery to the brain, as well as diseases of the brain’s vascular network go.nature.com/3ULhSjx

🚨🚨🚨🚨 Our new preprint is out! “Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations” 🩸🧫🧪🧬 biorxiv.org/content/10.110… The superteam of @cancer_curious and Dani Fernandez tackled a major unanswered question in HSC bio. 1/

This week selection of papers in myeloid leukemia biology and therapy is out. Enjoy the vast read and thanks as always @Bims_BiomedNews Here is the link biomed.news/bims-tremyl/20…

U.K. childhood leukaemia researchers- please join us on 19th Sep for the annual meeting- hosted by @Richardson_S_E in Cambridge. Keynote talk by Prof Brian Huntly. Register now!

What if we could exploit one of the proteins driving AML? Could we cut off #leukaemia’s energy source and uncover new ways to treat the disease? ⚡ Meet Dr Noelia Che from @ucl, who is using her 2023 John Goldman Fellowship to find out! 👉 leukaemiauk.org.uk/research-and-a…

Meet our amazing Post-Doc Dr. Noelia Che @noelia_che 👏

@noelia_che @DBC_ICH @UCLchildhealth Congratulations @noelia_che 👏👏 well deserved

Thanks to session chairs @Richardson_S_E and @WilliamsLabUCL . We missed you @MariaTeresaEs

Throwback from #KindPhilipp2023 in #Wilsede looking forward to see you all next year at #KindPhilipp2024

A conference like no other! #KindPhilipp2023 Congratulations to @rolf_marschalek @JhKmann Olaf H and Martin Stanulla for organising such an amazing meeting.

Great to be back in Wilsede. @rolf_marschalek is opening #KindPhilipp2023. We are looking forward to 4 days filled with great science from @Jeremias_lab @florian_grebien @Menendez_Lab @andiroy @ChrBraun02141 @WilliamsLabUCL @Ullrich_Lab @HannahUckelmann and many others.

Interested in starting a PhD in child health? We have fully funded Child Health research PhD studentships available. Application deadline: 9 January 2023. Find out more: ucl.ac.uk/child-health/s… @UCLPopHealthSci @DNP_ICH @DBC_ICH @GGM_ICH @ich_ppp @GreatOrmondSt

📢Interested in studying the effect of radiation treatment on the #TME and how to combine radio and immune therapies for #childhoodCancer: Come and join our team @uclcancer @RadNetCRUKCoL Don't hesitate to contact me if you want to know more. ucl.ac.uk/work-at-ucl/se…

We have two postdoctoral positions available in our lab, to study #childhoodALL, funded by @NIH and @The_MRC . Join our team in beautiful Oxford @MRC_WIMM @OxPaediatrics @UniofOxford . Link below for more details, and happy to chat! my.corehr.com/pls/uoxrecruit…