disco

@charliekirk11 RIP Charlie here's to your final mic drop I salute you

@perplexity_ai badass

Perplexity Computer now connects to your health apps, wearable devices, lab results, and medical records. Build personalized tools and applications with your health data, or track everything in your health dashboard.

@nickshirleyy Good work

🚨 Here is the full 40 minutes of my crew and I exposing California fraud, Minnesota was big but California is even bigger... We uncovered over $170,000,000 in fraud as these fraudsters live in luxury with no consequences. Like it and share it, the fraud must STOP. We ALL work way too hard and pay too much in taxes for this to be happening. These fraudsters have been able to defraud American taxpayers for years without any pushback from the public and politicians. It is time to EXPOSE IT ALL and end America's fraud crisis.

The biggest-selling drug on the planet last year was a peptide. Semaglutide, the molecule inside Ozempic and Wegovy, is a chain of just 31 amino acids. It generated roughly $33 billion in revenue for Novo Nordisk in 2025. One molecule. The entire peptide drug market crossed the $50 billion mark. Finding the right peptide is where all the money burns. For each disease protein, you need to design a peptide that binds tightly enough actually to work. Think of it like making a custom key for a lock, except each position on the key can take 20 possible shapes, and even a short 10-position peptide can have over 10 trillion possible combinations per target. The two best AI tools for this, BindCraft and BoltzGen, work by first predicting a peptide's 3D shape, then checking whether it sticks. That two-step process generates one candidate every few seconds to a few minutes. A whole day might get you a few hundred designs. LigandForge skips the shape-prediction step entirely. It learns the physics of molecular interactions and generates sequences directly from the shape of the target protein’s docking site. No iteration, no structure prediction during generation. Over 700 peptide sequences per second on a single GPU. That’s 10,000x faster than BoltzGen, over 1,000,000x faster than BindCraft. Speed means nothing if the peptides are garbage, though. So they tested it on five targets that have historically been difficult to bind: TNF-alpha, the target behind the rheumatoid arthritis blockbuster Humira. PD-L1 is the immune checkpoint that cancer immunotherapy drugs like Tecentriq block. VEGF-A, the target for cancer drug Avastin. HER2, breast cancer drug Herceptin’s target. And IL-7R-alpha. LigandForge generated 150,000 candidates across all five in 3.4 minutes and produced tightly binding candidates (predicted binding strength in the low nanomolar range, where real drugs operate) against all five. BoltzGen hit 1 out of 5. BindCraft hit 0. A 2020 JAMA study pegged the median cost of bringing a single drug to market at $985 million. The early discovery phase, where you’re searching for molecules that bind to your target, can take 1 to 6 years. A tool that searches the same space a million times faster changes how many disease targets a lab can afford to go after at once.

@Erik80599 Yup

Bacteriophages (phages) can be "engineered" for drug delivery after a heart attack by employing phage display technology to target damaged cardiac tissue and using genetic engineering to attach therapeutic proteins, genes, or nanoparticles while minimizing off-target effects 🕷️⚕️

@SciTechera Bring on the phages

Superhuman power is near Scientists just found have a gut bacterium that can boost muscle strength 👀 Researchers have identified a gut bacterium called Roseburia inulinivorans that is associated with greater muscle strength and physical performance. The study, published in Gut, analyzed 124 participants and compared their gut microbiome with strength and fitness tests. People with higher levels of this bacterium showed stronger grip strength and better aerobic fitness, with older adults demonstrating up to 29% greater grip strength. In animal experiments, mice given the bacterium showed about a 30% increase in grip strength, suggesting gut microbes may influence muscle metabolism and the development of fast-twitch muscle fibers linked to power and strength.

@claudeai ...and its ded

A small thank you to everyone using Claude: We’re doubling usage outside our peak hours for the next two weeks.

@abumezege1 @wagsischasing mout

@wagsischasing You gats brush before you play this kind game, make dem no use mouth odor kill person oh

I’ve lost way too much money betting on this shit.

Couldn’t script it better

@MegaphoneNewsEN Human shield failure, boo hoo

In its attack on Western Bekaa on Thursday evening, the Israeli army killed four members of the Ghazali family after targeting their home in Mashghara. The victims were referee Qassem Ghazali, his brother Ibrahim, and Ibrahim’s children, Ali and Fatima. The Israeli assault on Lebanon continues, with airstrikes hitting various areas in the South, Bekaa and Dahiyeh. The Ministry of Health announced that the death toll from the attacks has risen to at least 123.

@DrAnneDerry If they took your family and would not give them back, you would not do the same, turn every stone to find them? Hypocrite liar

Imagine thinking that the blood thirsty warmongers who did this to Gaza are "God's chosen people". What an utter perversion of Scripture.

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

New York is cooked

@mralpacalips @iAnonPatriot its so good 🤣

@WinningMfer @iAnonPatriot Thank you Mr. Simon Cowell.

Liberal white people will literally tell you to stop being “Islamophobic” while Muslims launch bombs over their heads… We’re dealing with the dumbest people to ever exist

@mralpacalips @iAnonPatriot

@iAnonPatriot I think it is the perfect setup for an odd couple sitcom - every episode explosive fun!

@iAnonPatriot you cant even make this up 🤣🤬

First night without missiles on Israel from Iran! So let's start the morning with this beautiful footage of an Iranian drone carrier ship getting blasted!

On our way to make history ✈️