The Anslyn Lab @ UT-Austin

Researchers use electrochemistry to read data stored in molecules The technique offers a less expensive approach to oligomer sequencing than mass spectrometry. cen.acs.org/materials/poly…

#ElectrochemistryIsEverywhere Can be used to read information encoded in molecular sequences that store data/messages. “They demonstrated the technique by encoding an 11-character password written into 11 different molecules, decoding it, and using it to unlock a computer.”

Excited to share our latest publication in Chem by Cell Press! In this work, we discuss a new electrochemical sequence method for sequence-defined oligourethanes, presenting as a promising alternative to mass spectrometry-based approaches! cell.com/chem/fulltext/…

Check out the latest paper from our group! After 75 Years, an Alternative to Edman Degradation: A Mechanistic and Efficiency Study of a Base-Induced Method for N-Terminal Peptide Sequencing | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Our most recent work in the area of SDPs is out now! A Workflow Enabling the Automated Synthesis, Chain-End Degradation, and Rapid Mass Spectrometry Analysis for Molecular Information Storage in Sequence-Defined Oligourethanes | JACS Au pubs.acs.org/doi/10.1021/ja…

Excited to share our latest findings about an interesting molecular fragmentation and recombination mechanism for synthesizing GFP chromophore analogues, published in JOC @JOC_OL. Many thanks to my advisor Prof. Eric Anslyn and colleagues @WizardsOfOztin pubs.acs.org/doi/10.1021/ac…

Our latest paper on ee determination assay for chiral amines👇👇 Data-science-guided calibration curve prediction of an MLCT-based ee determination assay for chiral amines: Chem cell.com/chem/fulltext/…

Excited to share our newly published JACS paper on the selective capture and fluorescent labeling of N-terminal Glycine peptides.  Many thanks to my postdoc advisor Prof. Eric Anslyn and colleagues at the Anslyn group @WizardsOfOztin pubs.acs.org/doi/10.1021/ja…

Congratulations to Eric Anslyn on his election to the American Academy of Arts and Sciences! @americanacad @WizardsOfOztin news.utexas.edu/2024/05/02/4-u…

Chemical and linguistic considerations for encoding Chinese characters: an embodiment using chain-end degradable sequence-defined oligourethanes created by consecutive solid phase click chemistry - now published in Chemical Science pubs.rsc.org/en/content/art…

The Anslyn Lab, 2024 Edition!!

The JACS team mourns the loss of Professor Allen J. Bard of the University of Texas at Austin. Bard served as Editor-in-Chief of Journal of the American Chemical Society from 1982-2001. As a scientist, teacher, and mentor Bard inspired countless individuals. He will be missed.

For a second, I thought that this is a self-assembly of hot carbon atoms into graphene on a surface)

The Anslyn Lab group photo, 2023 Edition!

Recent advances in fluorescent and colorimetric chemosensors for the detection of chemical warfare agents: a legacy of the 21st century - now published in Chemical Society Reviews pubs.rsc.org/en/content/art…

Have you ever wondered about the limits of the ribosome's ancient bond forming mechanism? Beyond polypeptides/polyesters, what else is possible? Now @NatureComms, @NUSynBio show that the ribosome can make pyridazinone bonds via cyclocondensation reactions nature.com/articles/s4146…

Most recent work from the Anslyn lab! Congratulations James Howard and the team!!! Data-Driven Prediction of Circular Dichroism-Based Calibration Curves for the Rapid Screening of Chiral Primary Amine Enantiomeric Excess Values pubs.acs.org/doi/10.1021/ja…

Our most recent work!!!

@ACSpressroom @ACSCentSci @UTAustin @UMassLowell "what if we like, embedded the oligos in ink and then wrote a letter, but the letter wasn’t the message the ink was" @dollhouser @SarahMoor13 @WizardsOfOztin

It sounds like something out of a spy movie, but scientists at @UTAustin & @UMassLowell recently mailed & extracted an encrypted version of ‘The Wonderful Wizard of Oz’ book hidden within the ink of a personal letter. @WizardsOfOztin @UTChemistry cns.utexas.edu/news/scientist…