Matthew Wortham

We are once again recruiting at all levels! See links for postdoc tinyurl.com/36bttteu and technician tinyurl.com/3ycemtdt position ads. Read more about our research in our latest preprint biorxiv.org/content/10.648… and on our website worthamlab.org.

Delighted to share that the @NIDDKgov funded @iidp_at_coh is reporting characterization of close to 300 organ donors. Working at this scale there are lots of insights into the heterogeneity of islets even in people without diabetes but most importantly the data behind this paper are now available on the IIDP RDR for others to explore and use for their own research. At the @ADA_DiabetesPro meeting next month the NIDDK funded @PanKbase will also release a browser to explore some of these data in concert with other omic data. It takes a village to do this type of science including dedicated funding over decades to support the infrastructure. Proud to have played a small part in this effort which was championed by #IIDP co-directors @cevansmo & @NilandLab and #HIPP director #MarcelaBrissova (not on X). Huge shout out to the many amazing early career investigators who have contributed to this work over the last decade particularly co-first authors- #YasminyePettway (not on X), @SethASharp @_dianecait . Link to Press Release - lnkd.in/gjwgunAS Link to paper - rdcu.be/figGz Link to data - iidp.coh.org @VUMChealth @VanderbiltU @StanfordMed @StanfordPeds @cityofhope @IndianaUniv @NIDDKgov

Our lab website worthamlab.org is up! By the way, we are recruiting at all levels. If our work interests you, consider joining us for cutting edge research in a collegial environment at University of Colorado Anschutz. Not to mention that Denver is a great place to live.

Awesome, congrats @Jen_Suzanne !

Ecstatic to finally share the next installment of our work today in @ScienceMagazine! Check it out to learn how early-life microbes shape islet development and longterm metabolic health science.org/doi/10.1126/sc…

Things I wish more people knew about doing science in the US (thread):

Metabolism-driven chromatin dynamics: Molecular principles and technological advances dlvr.it/THSntT

We are excited to bring the Speed Networking to the HIRN Annual Meeting (Jan 13-14) #HIRN2025! This is a great opportunity for pre-tenure early career PIs to set up a research collaboration with established PIs through a 1-on-1 speed meeting.

Studies of human #islets reveals the abundance of δ cells showed the strongest association with insulin secretion and was also associated with the genetic risk score (GRS) for #T2D @VUMChealth @VanderbiltU @annagloyn biorxiv.org/content/10.110…

This Thursday 12/5 Cristina Aguayo-Mazzucato @caguayo discussing beta cell senescence. Come join us! Dm for zoom link.

Busy week - Just out in @Cell_Metabolism: The work with the Metallo lab @salkinstitute showing that trans-fat promotes hepatic serine palmitoyltransferase flux (SPT), VLDL secretion, and #atherosclerosis. SPT inhibition reduces VLDL and atherosclerosis. sciencedirect.com/science/articl…

@ScienceDrBini Awesome news, congrats Jason!

Now that the ink is dry... I can announce a promotion to Assistant Professor here at Yale starting in Jan 2025.🥳 Looking forward to continue to grow the Yale PET/Endocrine research program. A hearty thank you to all my mentors who have helped me along the way.

Please join us Thursday Nov. 14: @AGOcanaLab_COH on therapeutics for beta cell regeneration.

The heterogeneous enhancer responses to metabolic challenges in individual β cells #islets #diabetes @NatureComms nature.com/articles/s4146…

New! Online now: Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase dlvr.it/TFrR4n

Have you ever wondered how mitochondrial and cytosolic pathways for de novo lipogenesis (DNL) interact? We did! Published Online today (cell.com/cell-metabolis…) and led by first-author @adam_rauckhorst, we traced 13C-labeled lactate/pyruvate, acetate, the ketone acetoacetate, and leucine in several mouse models of disrupted hepatic mitochondrial and cytosolic acetyl-CoA generating pathways. Surprisingly, deleting the mitochondria citrate carrier (CiC) increased DNL from both exogeneous and leucine-generated acetoacetate. Overall, our findings delineate a mitochondrial-cytosolic DNL substrate supply network that may guide more accurate therapeutic development for MASLD and T2D. Many thanks to our expert collaborators: No X Ryan Sheldon, now leading metabolomics at the @VAInstitute, who helped start the project and develop the necessary mass spec methods with @adam_rauckhorst; for @StanislawDeja and @Isotopomer for deuterium tracing by NMR and careful contibutions to quantitatively framing our mass spec data; and Tom Vallim of @TarlingVallim for guidance with in vivo gene deletion by AAV CRISPRs. Please also see the exciting co-published manuscript from @WellenLab and Christian Metallo Labs (cell.com/cell-metabolis…) showing that bempadoic acid does more than just inhibit ACLY! @FOEDRC, @UIowaResearch, @UIMolecPhysBio

Preclinical data implies calorie restriction could be a feasible approach to preserve compromised beta cell structure-function during #aging and #diabetes @NatureComms nature.com/articles/s4146…

Huge congratulations to @bcellorg the winner of this year’s Grodsky Lecture. Extraordinary scientist and incredible collaborator - fantastic lecture - what a treat!

Our latest out today @Nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…

Super proud of the amazing @nkrentz the recipient of this years John Hutton Rising Star Award from #WRISG2024 - a rockstar 🤩 scientist & a lovely person. Richly deserved 🙌🙌🙌🙌🙌