Matthew Wortham

Our lab website worthamlab.org is up! By the way, we are recruiting at all levels. If our work interests you, consider joining us for cutting edge research in a collegial environment at University of Colorado Anschutz. Not to mention that Denver is a great place to live.

Awesome, congrats @Jen_Suzanne !

Ecstatic to finally share the next installment of our work today in @ScienceMagazine! Check it out to learn how early-life microbes shape islet development and longterm metabolic health science.org/doi/10.1126/sc…

Things I wish more people knew about doing science in the US (thread):

Metabolism-driven chromatin dynamics: Molecular principles and technological advances dlvr.it/THSntT

We are excited to bring the Speed Networking to the HIRN Annual Meeting (Jan 13-14) #HIRN2025! This is a great opportunity for pre-tenure early career PIs to set up a research collaboration with established PIs through a 1-on-1 speed meeting.

Studies of human #islets reveals the abundance of δ cells showed the strongest association with insulin secretion and was also associated with the genetic risk score (GRS) for #T2D @VUMChealth @VanderbiltU @annagloyn biorxiv.org/content/10.110…

This Thursday 12/5 Cristina Aguayo-Mazzucato @caguayo discussing beta cell senescence. Come join us! Dm for zoom link.

Busy week - Just out in @Cell_Metabolism: The work with the Metallo lab @salkinstitute showing that trans-fat promotes hepatic serine palmitoyltransferase flux (SPT), VLDL secretion, and #atherosclerosis. SPT inhibition reduces VLDL and atherosclerosis. sciencedirect.com/science/articl…

@ScienceDrBini Awesome news, congrats Jason!

Now that the ink is dry... I can announce a promotion to Assistant Professor here at Yale starting in Jan 2025.🥳 Looking forward to continue to grow the Yale PET/Endocrine research program. A hearty thank you to all my mentors who have helped me along the way.

Please join us Thursday Nov. 14: @AGOcanaLab_COH on therapeutics for beta cell regeneration.

The heterogeneous enhancer responses to metabolic challenges in individual β cells #islets #diabetes @NatureComms nature.com/articles/s4146…

New! Online now: Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase dlvr.it/TFrR4n

Have you ever wondered how mitochondrial and cytosolic pathways for de novo lipogenesis (DNL) interact? We did! Published Online today (cell.com/cell-metabolis…) and led by first-author @adam_rauckhorst, we traced 13C-labeled lactate/pyruvate, acetate, the ketone acetoacetate, and leucine in several mouse models of disrupted hepatic mitochondrial and cytosolic acetyl-CoA generating pathways. Surprisingly, deleting the mitochondria citrate carrier (CiC) increased DNL from both exogeneous and leucine-generated acetoacetate. Overall, our findings delineate a mitochondrial-cytosolic DNL substrate supply network that may guide more accurate therapeutic development for MASLD and T2D. Many thanks to our expert collaborators: No X Ryan Sheldon, now leading metabolomics at the @VAInstitute, who helped start the project and develop the necessary mass spec methods with @adam_rauckhorst; for @StanislawDeja and @Isotopomer for deuterium tracing by NMR and careful contibutions to quantitatively framing our mass spec data; and Tom Vallim of @TarlingVallim for guidance with in vivo gene deletion by AAV CRISPRs. Please also see the exciting co-published manuscript from @WellenLab and Christian Metallo Labs (cell.com/cell-metabolis…) showing that bempadoic acid does more than just inhibit ACLY! @FOEDRC, @UIowaResearch, @UIMolecPhysBio

Preclinical data implies calorie restriction could be a feasible approach to preserve compromised beta cell structure-function during #aging and #diabetes @NatureComms nature.com/articles/s4146…

Huge congratulations to @bcellorg the winner of this year’s Grodsky Lecture. Extraordinary scientist and incredible collaborator - fantastic lecture - what a treat!

Our latest out today @Nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…

Super proud of the amazing @nkrentz the recipient of this years John Hutton Rising Star Award from #WRISG2024 - a rockstar 🤩 scientist & a lovely person. Richly deserved 🙌🙌🙌🙌🙌

Join us for our next HIRN Webinar: "Circulating Extracellular Vesicles in T1D" Thurs, Oct 24th at 1:00 pm Eastern (10am PST) Presentations by Drs. Raghu Mirmira, Ernesto Nakayasu, and Emily Sims. All welcome but registration required. Register at: tinyurl.com/HIRN-Oct-2024

Save the date for #METPHYS2025 Registration will open very soon.