Alfred Lee

Very excited to share our work exploiting GS frameworks for structure elucidation of encapsulated guests in @ACSMatLett, @CGD_ACS & @ChemEurJ. The first two in collaboration with @aayusov, Allie Dillon & Mike Ward @nyumdi, & the latter led by @MoTChaudhry pubs.acs.org/doi/10.1021/ac…

Role of molecular strain in crystallization―Organic crystal structures, which have long been utilized in industrial-scale crystallization, can sometimes undergo sudden and unexpected transitions to alternative, more thermodynamically stable arrangements, resulting in markedly different physical properties. In their article in @J_A_C_S, van de Streek, Neumann et al. present a method for calculating “molecular strain energy” to predict the likelihood that a molecule will adopt its most thermodynamically stable crystal packing arrangement. This study not only elucidates the unexpected crystallization of more stable, novel solid forms but also provides the pharmaceutical industry with a valuable tool for directing resources more effectively. Full article: pubs.acs.org/doi/10.1021/ja…

Read our latest publication in @CommsChem showcasing ritonavir, the most celebrated case of crystal polymorphism.

A Conceptual Framework for the Crystallizability of Organic Compounds | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Less then 10 days to apply for a #Chemistry #PhD with our team at @ChemistryNCL, using high throughput robotics to discover crystallisation conditions for complex #peptides. Learn #crystallography and #SCXRD myself and @Mike_Pro_1978. Sponsored by @Merck ncl.ac.uk/postgraduate/f…

Just out in the Journal of Pharmaceutical Sciences: A salt or a cocrystal? That is the question. #MerckChemistry

Dynamic crystals are so much fun, and there are lots of collaborations involved in this research! More information here -> sas.rochester.edu/chm/undergradu… Please RT! @Pance_Naumov @NaumovGroup @leelab_nyu @RuncevskiLab @KM_Hutchins @ItsBenPartridge @brozeklab @BRBchemistry

Our latest work in @ChemEurJ on combining high-throughput experimentation and powder X-ray diffraction to identify promising host-guest complexes for structure elucidation purposes.

#MerckPharmSci #MerckAnalytical @PurdueIPPH

@ChEnected Congratulations @DiaoGroup !

Ying Diao of Univ. of Illinois Urbana-Champaign will receive the 2024 AIChE Allan P. Colburn Award, which is awarded to early-career members for excellence in publications. bit.ly/3MavAIU #AIChEAnnual #nanomaterials #nanoprinting

Unprecedented Packing Polymorphism of Oxindole: An Exploration Inspired by Crystal Structure Prediction (Alfred Lee, Xiaolong Zhu and co-workers) @XtalEngineer #MerckChemistry onlinelibrary.wiley.com/doi/10.1002/an…

#MerckAnalytical is hiring. Come join us to create new automation capabilities to overcome scientific challenges related to preformulation and formulation development. jobs.merck.com/us/en/job/R303…

@HengGroup @yanghuaiyu @BACG_ @JYYHeng @IshaBade @Jianing_Li_ Congratulations on the trifecta!!! 👏🏻

Good things come in threes  for the @HengGroup - enjoyable conference at this year’s BACG @BACG_ 2024 and for winning the three prizes! 💎👏#bestposter #bestpresentation #bestcrystal @JYYHeng  @IshaBade @Jianing_Li_

Benchmarking Guanidinium Organosulfonate Hydrogen-Bonded Frameworks for Structure Determination of Encapsulated Guests By @XtalEngineer, Michael D. Ward at Merck, @nyuniversity Read the paper 👉 go.acs.org/9xD

Guanidinium organosulfonate hydrogen-bonded frameworks can do it all: catalysis, selective encapsulation and control of tautomeric state (@MoTChaudhry, Justin Newman and Alfred Lee @XtalEngineer) #MerckChemistry onlinelibrary.wiley.com/doi/10.1002/ch…

Thank you @OPRD_ACS for highlighting our work on GS hydrogen-bonded frameworks in the recent installment of Some Items of Interest to Process R&D Chemists & Engineers. @nyumdi @CGD_ACS #MerckChemistry pubs.acs.org/doi/10.1021/ac…

A nice industry perspective on solid-state opportunities in tackling the evolving biopharmaceutical pipeline. Check it out! 👇

Immense appreciation to the MRL Postdoctoral Research Fellowship Program #MerckChemistry @nyuchemistry #Crystallography #StructureDetermination …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…

Huge thanks to the @NSF GOALI program and pubs.acs.org/doi/10.1021/ac…

Very excited to share our work exploiting GS frameworks for structure elucidation of encapsulated guests in @ACSMatLett, @CGD_ACS & @ChemEurJ. The first two in collaboration with @aayusov, Allie Dillon & Mike Ward @nyumdi, & the latter led by @MoTChaudhry pubs.acs.org/doi/10.1021/ac…

@MartinWard_xtal Two conferences in the fall that might be of interest to the organic solid-state community: 1) 25th ACT Larson Workshop 25thlarsonworkshop.comfre.iastate.edu 2) Pharma Crystallization Summit crystallizationsummit.com

Hi folks - a question to all the pharma/organic crystallisation and nucleation people here - what conferences are people looking forward to this year? I dont have much lined up so far so would be good to find out whats happening (I always find it so difficult to keep track)