Yeeles Lab

Great first day of EMBL DNA replication meeting in beautiful Heidelberg, including a hike to the Schloss with @Yeeles_Lab

Amazing talk from @JohannJRoske at the #LMB lab talks! Thanks to @this_clockwork for bringing the replisome to life 🧬🧬🧬

Excited for the first day of the UK DNA Replication Meeting 2024! First up: all things initiation. @BiochemSoc #BiochemEvent

🚨📣 Excited to share our latest work investigating how the replisome responds to topoisomerase-DNA crosslinks 🧬🔬 cell.com/molecular-cell… Fantastic work from @rosewesthorpe and @JohannJRoske 🍄🍄🍄🍄

We are excited to share new mechanistic insights into DNA replication fidelity! How does human DNA Polymerase Epsilon recognise and proofread errors made during synthesis? 🧬 Read @NatureSMB nature.com/articles/s4159…

Here's a render of a full eukaryotic replisome carrying out DNA replication. This was built using real .pdb data from @buildmodels I used this to make my latest video: (youtu.be/lv89fSt5jBY) But now I want to do a quick works cited 🧵 (1/ ?)

New paper from my group, in which we use the combined power of AlphaFold and biochemical reconstitution to determine how the Rrm3 helicase is targetted to the eukaryotic replisome embopress.org/doi/epdf/10.10…

Brilliant to see our talented postdoc, Cristian, publish his work on CMG disassembly in @embojournal. The culmination of his PhD work in the Labib lab at @dundeeuni. @TDDeego embopress.org/doi/full/10.10…..

Join us next year for the 2nd edition of the UK DNA replication meeting in Cambridge. The first meeting was fantastic so be sure not to miss out! @Yeeles_Lab @AgaGambus @saponaro_m eventsforce.net/biochemsoc/fro…

@TDDeego @mljones1993 Does a tuna sandwich count?

@Yeeles_Lab @mljones1993 Presumably preceded by some lobster?

Happy 30th Birthday to one of our favourite structural biologists @mljones1993 🥳🥳

Having fun at Cold Spring Harbor! @mljones1993 #cshldnarep #renaissanceman #howdoyoueatlobster

So excited to have arrived at @cshlmeetings Eukaryotic DNA Replication and Genome Maintenance!! Can’t wait to hear all of the amazing science and catch up with old and new friends 🧬 #cshl

Hi all. Two fully funded four year postdoc positions to study DNA replication initiation using human proteins. Please check out the ad and contact me if you want more info. Closing 30 September. crick.ac.uk/careers-study/… crick.ac.uk/careers-study/…

Online Now: How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication dlvr.it/Ssq3qW

Very happy and excited to share our latest work on Pol α-primase recruitment to the eukaryotic replisome! 🧬 ⬇️ #dnareplication #cryoEM #biochemistry

Our work on perforin-2, a pore-forming protein expressed by #DendriticCells to deliver antigens into the cytosol during #CrossPresentation is now out in @ScienceMagazine science.org/doi/10.1126/sc…… Huge amount of work from Pablo, in collaboration with @laub_marco & @Pati_Krawczyk

Come along to extract DNA from bananas with the Yeeles lab!