David Sykes

Check out this post on Drug Discovery 2025 linkedin.com/feed/update/ur… via @walls_io

A new take on β₂AR agonist signaling bias. Published in ACS Biochemistry pubs.acs.org/doi/10.1021/ac…

sciencedirect.com/science/articl… Allosteric modulators.

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay. frontiersin.org/journals/pharm…

Ligand efficacy at the beta2-adrenergic receptor explained... frontiersin.org/journals/pharm…

Interested in GPCR allosteric drug discovery? onlinelibrary.wiley.com/doi/10.1002/an…

Cool paper on CB receptors! nature.com/articles/s4146…

Here's how to harness the power of The Reality Distortion Field:

Visualization of membrane localization and the functional state of CB2R pools using matched agonist and inverse agonist probe pairs - now published in Chemical Science pubs.rsc.org/en/content/art…

We are delighted to welcome @DIVERSATechnlgs, @Z7biotech, fungtional.bio, Bio-Sourcing, @KyronBio! These startups explores areas in #nanotechnology, #mRNA therapeutics, #raredisease, and many more. Don't miss out on their showcase👉terrapinn.com/fob24/register…

Excited to share some outstanding research from the Veprintsev Lab in Nottingham by a former visiting PhD student, @BorregaLeire, and Postdoctoral Fellow, @brad_hoare. #compare #UoN #cannabinoids #GPCR #fluorescence #HTRF #pharmacology

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R) #CB1R #LiveCellImaging #GPCR #fluorescence #HTRF #pharmacology | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

@modern_elixir @ProfFeynman

The difference between information and knowledge:

@gunsnrosesgirl3 Messi> Ronaldo

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@gunsnrosesgirl3 Arsenal

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R) ift.tt/fyKrGnN #chemrxiv_biochem

Probing drug-target engagement of soluble Gαi1 protein using the SolThermoBRET thermal shift assay biorxiv.org/cgi/content/sh… #biorxiv_biophys

@gunsnrosesgirl3 Photons...