Simone Zaccaria

361 posts

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Simone Zaccaria

Simone Zaccaria

@ZaccaSimo

CRUK Career Development Fellow Group Leader of @CCG_UCL at the UCL CI @CRUKLungCentre and Visiting Scientist at the Francis Crick

UCL Cancer Institute Katılım Eylül 2015
271 Takip Edilen883 Takipçiler
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Oriol Pich
Oriol Pich@oriol_pich·
Happy to share our latest study @Nature , where we evaluate somatic evolution and the effect of treatment in normal tissue using duplex sequencing 1/n nature.com/articles/s4158…
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Simone Zaccaria
Simone Zaccaria@ZaccaSimo·
🚨 Thrilled to have helped @NickyMcGranahan co-supervise this brilliant work! ALPACA shows how SNVs can be used as barcodes to untangle complex evolution of clone-specific CNAs, revealing their crucial role in cancer progression and their prognostic potential! Read more👇
Nicholas McGranahan@NickyMcGranahan

Excited to share our new paper in @Nature, led by @PiotrekPaw_ @KristianaGrigo4 ! 🧬 We developed a new method, ALPACA, to untangle the co-evolution of single nucleotide variants and copy number changes in tumours. Check it out: tinyurl.com/yrppttr3

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ISCB News
ISCB News@iscb·
We're a month out from #ISMBECCB2025!  You can now access the abridged agenda, downloadable schedules, poster listings, and SciFinder search tool links directly from the homepage: iscb.org/ismbeccb2025/h… Click the link you need, or use the Programme &  Agenda menu for more options!
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ISCB News
ISCB News@iscb·
Be a part of ISMB/ECCB 2025: Shape the future of computational biology. Attend in-person in Liverpool or virtually for live sessions, Q&A, and exclusive networking. Elevate your research at the forefront of bioinformatics!
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Simone Zaccaria
Simone Zaccaria@ZaccaSimo·
Huge congratulations to @LucreziaPatruno from @CCG_UCL for being awarded one of the best abstract awards at AI in Oncology in Paris, we are so proud! Join ISMB to hear her full story on the next advances in call CNAs from single cell seq!
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Charles Swanton
Charles Swanton@CharlesSwanton·
Now the incredible Mariam Jamal-Hanjani presenting data from the TRACERx Peace cohorts defining the metastatic cascade in Nsclc ⁦@CRUKresearch⁩ ⁦@uclcancer⁩ ⁦@TheCrick⁩
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Elsa Bernard
Elsa Bernard@Elsa2Bernard·
Excited to see our @NEJM paper out on tumor-infiltrating CH, tumor evolution, and patient outcomes. A privilege to work w/ friends @oriol_pich and Maria Zagorulya with invaluable support from @PapaemmanuilLab and @CharlesSwanton @MSKCancerCenter @TheCrick @GustaveRoussy 👇👇
Oriol Pich@oriol_pich

🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton + more nejm.org/doi/full/10.10…

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Oriol Pich
Oriol Pich@oriol_pich·
There’s much more in the paper: 👉 Single-cell genomic data from patients with TI-CH @AdamMead_Oxford 👉 TI-CH in metastases, including autopsy samples from the PEACE study @CR_UK 👉 Functional experiments with the help of many labs, including Dominique Bonnet's @TheCrick
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Simone Zaccaria
Simone Zaccaria@ZaccaSimo·
🙏 I am so grateful to @uclcancer and all my colleagues at the institute for their constant and incredible support 🙏 Thanks to @EMBO and @EMBO_YIP for this great opportunity; excited for the journey ahead!
UCL Cancer Institute@uclcancer

Many congratulations to @ZaccaSimo selected as an @EMBO Young Investigator - "a group of exceptional scientists who represent innovation and excellence in their fields" ⭐️👏 ucl.ac.uk/medical-scienc… @uclmedsci @CRUKCOLcentre

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Maria Secrier
Maria Secrier@mariasecrier·
Delighted to introduce our new spatial transcriptomics tool, SpottedPy, recently published @GenomeBiology, allowing the identification of tumour hotspots at different scales and the exploration of distances and overlap with tumour microenvironment niches: genomebiology.biomedcentral.com/articles/10.11…
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Simone Zaccaria
Simone Zaccaria@ZaccaSimo·
🚨Very proud of this commentary led by @Rija_Zaidi_ reasoning on the method and experimental design impact on cancer evolution understanding, motivated by the outstanding work of @TheBoutrosLab, @VanLooLab, @kellrott et al Orig. work 👉 doi.org/10.1038/s41587… Our Commentary 👇
Rija Zaidi@Rija_Zaidi_

How much do algorithmic and experimental choices drive the accuracy of reconstructing tumour evolution? In this @CR_AACR commentary, @ZaccaSimo and I discuss a recent @NatureBiotech benchmarking paper exploring this question:

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Rija Zaidi
Rija Zaidi@Rija_Zaidi_·
How much do algorithmic and experimental choices drive the accuracy of reconstructing tumour evolution? In this @CR_AACR commentary, @ZaccaSimo and I discuss a recent @NatureBiotech benchmarking paper exploring this question:
Cancer Research@CR_AACR

#TumorEvolution reconstruction is heavily influenced by algorithmic & experimental choices—this In the Spotlight commentary by @Rija_Zaidi_ & @ZaccaSimo highlights a recent @NatureBiotech paper by @TheBoutrosLab, @VanLooLab, @kellrott, @MaxGalder, et al. bit.ly/3VAMRQs

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Keşfet

@Nature @CELL @MDAndersonnews @KaileWang @RuiYejerry @CRUKresearch @RosetreesT @CRUKCOLcentre