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@ZymoSuperMan

Structural Biologist

Wonderland Katılım Mayıs 2021
867 Takip Edilen445 Takipçiler
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M M@ZymoSuperMan·
دوستانی که مشکل دارویی پیدا کردین اگر ساکن تهران یا کرج هستید در این ایام زیر این پست پیغام بگذارید من در حد توانم تلاش میکنم کمکتون کنم.
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Saffron Sniper@Saffron_Sniper1·
A Ukrainian drone drops a bomb on an injured Russian soldier. What happens next feels unreal. The bomb lands right beside him… and he casually picks it up and throws it away like it’s just a ball. A level of bravery so raw, even the enemy would respect it 🫡
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M M@ZymoSuperMan·
@GBX_Press Oh look the orange pig
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GBX@GBX_Press·
🚨 JUST IN: ​Donald Trump: "Iran has been given only 24 hours. After that, the world may witness one of the most devastating air strikes ever seen."
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M M@ZymoSuperMan·
@amjadt25 Amjad you’re fucked and we are coming for you. So you better learn swimming quick you stinky little pig
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Amjad Taha أمجد طه
You are either with the UAE or with the evil Islamic regime. No silence is accepted. Right now, the Islamic regime in Iran is targeting my beloved country, the UAE, with drones and missiles. The UAE is crushing them, intercepting, destroying, and defending not just its land, but the safety of over 200 nationalities who call it home. Stand clear. Choose your side. UAE is safe and strong.
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M M@ZymoSuperMan·
Working what you fucker. You are literally irrelevant!
Ursula von der Leyen@vonderleyen

Today, our partner, the UAE, was once again the target of a vicious missiles and drone attacks originating from Iran. I extend my full solidarity to @MohamedBinZayed, the people of the UAE, and our partners across the Middle East. These attacks are unacceptable and constitute a clear violation of sovereignty and international law. Security in the region has direct consequences for Europe. So we will keep working closely with our partners on de-escalation and diplomatic resolution, to bring an end to the Iranian regime’s brutal actions. Both against its neighbors and its own people.

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M M@ZymoSuperMan·
@Halo_chains of wealthy donors. Once I went to visit her grave 8 am on weekend, I saw an old lady cleaning her grave stone. She told me she was a cleaner at her school. My mum had helped her and her disabled child buy an apartment somewhere in a suburb. Was shocked tbf.
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M M@ZymoSuperMan·
@Halo_chains My mum was a head master at a school in Iran during late 80s. I clearly remember the post war society. We were all poor. Some were very poor. Some kids would eat every other day. My mum used to have a list of the really poor families and tried to support them financially by help
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M M@ZymoSuperMan·
@payam_ek چطور دارایی بهشون گیر نمیده؟
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پیام الیاس کردی | Payam Elyas kordi
لاتاری ۳۰٪ الی ۴۵٪ زیر قیمت خودرو باعث شده مردم برای روز پنجشنبه دارایی هایی مثل ارز ، طلا و صندوق طلا و نقره رو بفروشن و پول رو برای آخر هفته و بخت آزمایی خودرویی آماده کنند ! مثلا همین پیش فروش خودرو باعث شده ورود پول به صندوق طلا و نقره امروز متوقف و منفی هم بشه.
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M M@ZymoSuperMan·
@Terror_Alarm Why would an Indian cow get itself in middle of something bot related to them
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M M@ZymoSuperMan·
هر روز میرم جاده بنزین ماهم تمام شده بود جایگاه گفت سوخت ندارم لیتری ۶ تومن نهایتا زدم.
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M M@ZymoSuperMan·
@FaceTheNation Instead of this rubbish just approve the damn drug so we can all access it
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Face The Nation@FaceTheNation·
Some hope for the tens of thousands of American families affected by pancreatic cancer: The FDA is granting early, expanded access to a promising experimental drug, daraxonrasib. The drugmaker Revolution Medicine reports it nearly doubled survival time for patients with advanced pancreatic cancer in a large Phase 3 clinical trial.
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M M@ZymoSuperMan·
@AlvaroCurielGa1 But only is US. My brother has cholangiocarcinoma with a kras mutant and we are desperate for it
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M M@ZymoSuperMan·
@chuminhua432 Do you have wechat? I need. Advice on how to get in contact with genfleet
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Minhua Chu
Minhua Chu@chuminhua432·
🇨🇳 GenFleet Therapeutics has registered the first Phase 3 clinical trial of GFH375 (VS-7375) in China CDE platform. GFH375 is a KRAS G12D inhibitor. In August 2023, GenFleet Therapeutics and Verastem reached an exclusive licensing and early collaborative development agreement to co-develop three innovative anti-tumor therapies targeting the RAS pathway. In December 2023, Verastem selected GFH375 (VS-7375) as the lead project of their collaboration. In January 2025, Verastem exercised its option, obtaining the development and commercialization rights for GFH375 (VS-7375) outside Greater China.
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M M@ZymoSuperMan·
@ilyassahinMD My brother has advanced cholangiocarcinoma with a g12d kras mutation. He lives outside US. Is there anyway you could sponsor him for this treatment? There are no clinical trials for him neither
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ilyas sahin, MD
ilyas sahin, MD@ilyassahinMD·
FDA just granted expanded access for daraxonrasib by Revolution Medicines. This allows patients who cannot enroll in a clinical trial to access the drug through their physician. The FDA processed this in just 2 days. That is unusually fast and reflects the urgency around pancreatic cancer. For a disease where second-line survival has historically been well under a year, every week matters. Progress is real✅
ilyas sahin, MD@ilyassahinMD

Great news for pancreatic cancer.* RAS alterations are present in most cases. Daraxonrasib (RAS(ON) inhibitor) in Phase 3 previously treated PDAC: OS 13.2 vs 6.7 months. FDA submission planned. A potentially practice-changing result✅✅✅

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M M@ZymoSuperMan·
Its crazy that i have had this same tweet replied to me from different accounts which even look legit. This dr pat sounds a bit like dr nick riviera from the simpsons. Shame people like me who feel stuck in a hole and would cling onto anything can get cheated by these frauds.
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M M@ZymoSuperMan·
@Gaurab Btw ICH acceptable range for an unkown impurity is 0.1% and 0.15% only for characterised impurities
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M M@ZymoSuperMan·
@Gaurab How are these drugs compounded in a pharmacy? We dont have that in our country? Isnt this drug injection?
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Gaurab Chakrabarti
Compounders mix tirzepatide with vitamin B12 to evade FDA regulations. The two molecules react. Up to 10% of every dose is a chemical no one has ever tested. In March, Eli Lilly tested 10 samples of compounded tirzepatide pulled from pharmacies, medspas, and telehealth networks. Every sample contained the same novel impurity. The FDA qualification threshold for impurities in approved drugs is 0.15%. Lilly found the B12 adduct at 67x that threshold. Some samples came in at 43% of labeled potency. Tirzepatide took Eli Lilly 7,023 iterations to get it right. They threw away 7,022 of them. Each variant changed an amino acid sequence, a linker, or a half-life. Compound 7,023 was the only one that survived. A single amino acid substitution changes how this molecule binds, clears, and tolerates. Compounders cannot match Lilly's precision. Add B12, and the reaction creates an adduct that has never been near a trial. Except for the people who are now injecting it.
Gaurab Chakrabarti tweet media
Brett Caughran@FundamentEdge

Super awesome that one of the most respected active healthcare investors, Mike Rockefeller (Co-CIO at Woodline and formerly a top Citadel PM) started a podcast interviewing healthcare CEOs. When I was a PM, I would occasionally share group meetings with Mike, and I would just sit back with a bias to let him drive - he had great relationships with his management teams and was a skillful interviewer. I often learned more listening to his interactions with $PFE and $LLY than I would have if I butted in with my more basic questions to those companies (and I took notes on how he conducted his meetings to try to get better). Mike is a unique animal in that he knew his companies as deep/deeper than many LO/Tiger style investors, and was able to monetize that knowledge in a tight risk model at Citadel for many years. It is no surprise to me that Woodline has been successful. With the beauty of the hedge fund world’s growing embrace of social/YouTube, this alpha is now available to all of us for free. I recommend you listen & follow, mandatory watching if you are a healthcare investor, and thanks for doing this Mike. First session with Dave Ricks of $LLY youtu.be/aN-GJTt1y8k?si…

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