Ian Boys

A bit under two years ago, @ElEarlyBird & I jumped on the #AlphaFold2 bandwagon. Could ab initio modeling guide studies of host-virus interactions in poxviruses? For the deep dive, see our @CellReports article cell.com/cell-reports/f…. For some highlights, continue below!

I’m thrilled to share a @biorxivpreprint for my postdoc work in the @PerrimonLab🎉. Together with our collaborators, we built a tissue-specific atlas of circulating secreted proteins in Drosophila 🧬🪰🧪🗺️. Thread below🧵 1/8 biorxiv.org/content/10.110…

I'd love to be in a timeline where an AI wouldn't cold-email you having "read" your recent preprint and come up with an "exciting Novel Hypothesis" to improve your work that is, shocker, largely behind a company's paywall. This isn't what we should be using ML for, dammit.

Does anyone have a sense for how long it takes for an unannotated eukaryotic genome to process w/ NCBI following submission? The official "at least two weeks" is pretty vague & we're closing in on a month and a half. Also it's 2025 so I guess past experience may be irrelevant.

@thesteinegger Super excited to have this resource as an alternative to folding viral proteins "in-house" - thank you!

Have been pretty quiet here for a while, but this is something I'm supposed to excitedly share, no? Extremely excited to begin my transition into the next phase - lots of exciting work on the evolution of immune (and anti-immune) proteins ahead! Thank you @NIGMS!

Nearly a thousand fewer doctors applied to residency programs in Utah this year. Researchers noticed a pattern among the states experiencing the most severe losses in applicants: They had adopted restrictive abortion policies. sltrib.com/news/politics/…

@Wenchun_Fan Just cells! Though I do have a couple of tanks of snails... 🐌

@_iboys wait, you have a reptile house? 🦎

"gekko cells are extremely sticky" ranks pretty high on my dumb little internal list of things I find funny, right next to "for frog cells, take culture media and dilute it with a ton of water"

Oh also: "snail cells grow really slowly" might top said list

#PreprintAlert🚨Please share. Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta @ChandniBhickta @NChiaruttini & in co. with @burnsajohn. **𝗧𝗵𝗶𝘀 𝗶𝘀 𝗡𝗢𝗧 𝗮𝗻 𝗮𝗻𝗶𝗺𝗮𝗹 #𝗲𝗺𝗯𝗿𝘆𝗼** LINK ➡️tinyurl.com/MultiCSg Buckle up for a LONG 🧵(sorry)

Follow-up: I ended up borrowing someone's computer to do this using Geneious. I try to avoid expensive software (especially subscriptions!) when community alternatives exist, but man did it make this easy.

Does anyone have tool recommendations for sgRNA design using an in-house (nonmodel) assembled genome as a reference for specificity? Seems like there are several options, wondering if anyone could vouch for specific ones. Thanks!

I'm late to the party retweeting this, but I highly, highly recommend taking a look at the Hilbert lab if you're interested in evolution and fungal pathogens. Zoë is an amazing scientist and will be a fantastic mentor for you if this is up your alley!

A section of a paper in a reputable journal is dedicated to “identifying” something you published two years ago and fails to cite your work/the body of work yours itself was built upon...

A little late to the party. Please apply for our newly posted faculty position in Evolutionary Genetics - broadly defined- here in the Department of Human Genetics at Utah @UofUHealth. PS: the photo below was taken 15 minutes from your new lab. utah.peopleadmin.com/postings/155357

@jkagan1 @russellevance IRF1? Makes sense as an individual, somewhat gentle/specific driver of some inflammatory signaling/IFNs, and a quick pubmed search turns up at least one study demonstrating it as an adjuvant in another vaccine type.

Which mRNA encoded proteins could work as vaccine adjuvant? No cytokine should work well, as several are needed to stimulate immunity. Most cytosolic protein PAMPs kill antigen presenting cells (work of @russellevance). Maybe PRRs, but which would be best?

@Aakanksha__Jain @FMKirbyNeuro @ThePasareLab Congrats Aakanksha!!

Excited to share that I have received the NIH HEAL K99 award to study the neuroimmune mechanisms of recurring pain. Thanks to my mentors Clifford Woolf @FMKirbyNeuro and @ThePasareLab for guidance and my amazing labmates for reading and re-reading my grant against their will 🤓.

@ProfessorPowder The other direction was pretty cool too

Sunset. 'nuff said

@ClementYChow In our defense we at least stuck with ones that were shoulder/pork/ham-adjacent. There was also a duck confit one that looked tempting...

@_iboys this is too fancy lol

I can’t believe that I didn’t know today was spam musubi day