Alex Waterson

Outstanding! Really looking forward to seeing how this develops!

#New research from VICB faculty! 🧪 🔹 Stephen Fesik and Alex Waterson co-authors a @JMedChem paper on BI-2493, a pan-KRAS inhibitor with in vivo efficacy 🔹 Ken Lau features in 3 studies on spatial transcriptomics, microbiota-immune signaling & data management @VUBasicSciences

Looking forward to this symposium and especially the keynote presentation by Marty Burke!

The National Academy of Sciences elected two Vanderbilt faculty to the 2025 class to recognize their distinguished and continuing achievements in research. Congratulations to Heidi Hamm (@VUBasicSciences) and Eric Skaar (@VUArtSci and @VUMedicine)!

It's a great example of the type of government sponsored collaborative research that lays foundations for drug discovery.

Sam Patnaik, @ncats_nih_gov , crushed his talk today at #AACR, describing the multi institutional discovery of potent and selective NNMT inhibitors.

@HartungIngo @Amgen @AACR Macrocycles for the win! Love a good cyclization story…

Brian Lanman @Amgen opening the first New Drugs on the Horizon session at #AACR25 with panKRas inhibitor AMG410. What an impressive example for structure-based multi-parameter optimization leading to a macrocyclic oral candidate molecule with selectivity over N/H-Ras. @AACR

21,000 announced attendance at #AACR25 . I think all of them are here in the Plenary session to see @kevansf talk about progress in KRAS drug discovery.

@HartungIngo You do a great service for us @HartungIngo. I got shunted to the overflow session for this one - your pics are far better than anything I could get!

Another excellent educational talk about ADC design aspects at #AACR25 by Rafaele Colombo. Linking payload potency & linker stability to clinical observations. Well, it remains complex to deduce generalizable design principles. Understanding payload fate is crucial.

This is a great summary of just part of the impact of ongoing biomedical research @VanderbiltU . Return on investment, indeed!

Big news in antibiotics! 🚨 The FDA just approved gepotidacin (Blujepa) for UTIs—thanks to research on DNA topoisomerases by Vanderbilt’s Dr. Neil Osheroff! 🧬 His work helped pave the way for this breakthrough. 🔗 Read more: linkedin.com/feed/update/ur…

We are delighted to welcome Fleur Ferguson to @VanderbiltU for today's @VICB_Vanderbilt seminar. Looking forward to some awesome science this afternoon!

@pottslab @Amgen Spectacular work @pottslab. This was a great read over today's morning coffee! Congrats to you and the team at @Amgen and @PlexiumTx .

Rational discovery of VHL molecular glues. New Preprint from @Amgen Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/7 biorxiv.org/content/10.110…

I was happy to treat @BurgeoningAW to a Hibachi dinner last night after he successfully defended his master's thesis. #ProudDadMoment As an aside, it was fascinating to sit in on a defense in an area so far outside of my field.

Sitting on the front row of today's @vicb_Vanderbilt seminar featuring @TheErinCalipari were former VICB director Gary Sulikowski, founding director Larry Marnett, and current director Doug Mitchell.

Exciting find in #JMedChem! Quinazoline compounds bind to SOS2 catalytic site and a new binding site discovered! #SOS2 #boehringer go.acs.org/cex

Way to go @ColleenNiswend2 !

Researchers at @VanderbiltU's Warren Center for Neuroscience Drug Discovery have developed a new compound aimed at addressing both positive symptoms and negative symptoms of #schizophrenia. Read more here: bit.ly/4gXVai9 #neuroscience #drugdiscovery #Science #Chemistry

🌟 @VanderbiltU CTTC proudly presents the 2024 Master Innovators, including three SOMBS faculty: Carrie Jones, @ColleenNiswend2, and @agwaterson! This honor recognizes faculty whose groundbreaking research has led to transformative innovations. 👏 news.vanderbilt.edu/2024/12/05/van…

It is nice to start the day with the following note: "We are pleased to inform you that your manuscript has been accepted for publication in Journal of Medicinal Chemistry."!