Dr. Annemieke Kavelaars

It’s been a year since the Supreme Court overturned Roe v. Wade. Since then, 14 states have banned most abortions, leaving millions of women and girls with nowhere to turn for the care they need.   And yet, there are reasons to hope.  After Roe v. Wade was overturned, voters in Michigan, California, and Vermont helped enshrine abortion rights in their state constitutions. And governors in states like Nevada, Hawaii, and Pennsylvania have signed executive orders to protect abortion access.

@GeoffroyLaumet @ish1789 @JulietMwirigi @dianatavf @mike_doc_B @UTDPainLab Couldn’t agree more!!

Stimulation of #Tcells by Inducible co-stimulatory molecule (ICOS) upregulates IL-10 and alleviates #CIPN . I love to see the CIPN resolution T cell, IL-10 story growing up jneuroinflammation.biomedcentral.com/articles/10.11… Congrats @ish1789 @JulietMwirigi @dianatavf @mike_doc_B @UTDPainLab

@Eijkelkamp_N @CTI_UMCUtrecht @IenI_UMCUtrecht @UMCU_Intl Fantastic news, congratulations!

Really happy and proud I will receive a ZonMw Vici award for our work on how the immune system and nervous system actively resolve pain to indentify highly needed new pain therapies! @CTI_UMCUtrecht @IenI_UMCUtrecht @UMCU_Intl zonmw.nl/nl/actueel/nie… umcutrecht.nl/nieuws/vici-be…

We have two exciting postdoc opportunities in the lab to study mechanisms of chemotherapy-induced neuropathy, and autoimmune mechanisms of chronic pain postdocjobs.com/posting/7125170 postdocjobs.com/posting/7125169. DM me for more details!

In case you are ready for a break. This is the debut album of my brother in law. open.spotify.com/album/7fQc2x37…

Above all, I dare you to do good So that the world might be great.

Congrats @JixiangZhang1 this a great piece of work showing that an HDAC6 inhibitor only apparently reverses chemo pain. In fact, the inhibitor induces tonic ENK-delta opioid receptor signaling to suppress ongoing mechanical hypersensitivity.

Very pleased to share our recent work: HDAC6 inhibition reverses cisplatin-induced mechanical hypersensitivity via tonic delta opioid receptor signaling. Thank you so much @akavel @CobiHeijnen @DrPeterGrace ! jneurosci.org/content/early/…

@Eijkelkamp_N @MichielVlist Wonderful news, great to see the recognition of the work of @Eijkelkamp_N. Congrats!

Really happy that together with @MichielVlist we are one of the awardees. Looking forward to embark on this project to uncover how macrophages help neurons to resolve inflammatory pain.

Another great paper examining neuroimmune mechanisms of CIPN from @akavel @GeoffroyLaumet and others. Interplay between CD8+ T-cell derived IL-13 and macrophage IL-10 is quite interesting #pain insight.jci.org/articles/view/…

CD8+ T cell–derived IL-13 increases macrophage IL-10 to resolve neuropathic pain: buff.ly/3MHiC4o @akavel @MDAndersonNews #Neuroscience

New paper in @JCI_insight: CD8 T cells and M2 macrophages collaborate to resolve pain. IL13 and IL10 are the players. doi.org/10.1172/jci.in… By Susmita K. Singh with @karenkrukowski @GeoffroyLaumet @CobiHeijnen @JenolynF_A @MDAndersonNews

CD8 T cells and M2 macrophages collaborate to promote resolution of pain. IL13 and IL10 are key. Susmita K. Singh, @GeoffroyLaumet @karenkrukowski @CobiHeijnen @JenolynF_A doi.org/10.1172/jci.in…

The next workshop in our #Pain2022 series is THIS FRIDAY! Bin Feng, Nick Spencer, @OliviaEllerPhD @Vijay_Samineni Register here: eventbrite.com/e/february-pai…

To prevent the long term cognitive side effects of some chemotherapies, scientists have developed a nasal therapy that delivers coated mitochondria to reverse neurotoxicity. @JenolynF_A @CobiHeijnen @akavel @A_Seua Learn more: ow.ly/LtIU50HQNBH

Targeting the meninges with nasal delivery of functionalized mitochondria resolves #chemotherapy induced cognitive deficits & signs of #pain ! Here’s how we did it @CobiHeijnen @akavel @A_Seua &others @MDAndersonNews @AdvSciNews onlinelibrary.wiley.com/share/author/B… #neuroscience #nano

Excited to share our latest research: macrophages, IL10, HDAC6 and Pain. Thanks for the greatest team and mentors. Dr Annemieke Kavelaars @akavel Dr Cobi Heijnen @CobiHeijnen and Vicky @jiacheng_ma . sciencedirect.com/science/articl…

Pain resolving macrophages: Macrophages resolve inflammatory pain by donating their mitochondria to sensory neurons. Team work with @MichielVlist @RaoofRamin @HLDMWillemen @LindeMeyaard. Proud! Such a fun, cool and inspiring collaboration. authors.elsevier.com/a/1eGBX3BtfGzl… A thread.1/n

Blake McAlpin currently defending his thesis on HDAC6 inhibition to treat chemobrain in mice

Thanks for a great talk and discussion!