AksimentievLab

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AksimentievLab

AksimentievLab

@aksimentievLab

We explore fascinating phenomena at the interface of physics, biology, and nanotechnology at the University of Illinois.

Loomis Laboratory, UIUC Katılım Aralık 2019
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AksimentievLab
AksimentievLab@aksimentievLab·
Great achievement from the Nivala lab! See also in News and Views: "Thread, read, rewind, repeat: towards using nanopores for protein sequencing" nature.com/articles/d4158…
Jeff Nivala@jeffnivala

Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

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AksimentievLab
AksimentievLab@aksimentievLab·
The variation of the electric field around a DNA duplex is surprisingly complex. Now, a nonlocal electrostatic theory can explain most of the features seen in all-atom MD simulations. Many thanks to Alexei Kornyshev, @JonathanGHedley @KushCoshic and @LeverhulmeTrust
Physical Review X@PhysRevX

A theoretical analysis of the complex electric field around DNA uncovers the origin of oscillating field patterns and sheds light on the role of the solvent that surrounds the DNA. Read go.aps.org/47hR1Bn @JonathanGHedley @KushCoshic @aksimentievLab #PRXBio, #PRXChem

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AksimentievLab
AksimentievLab@aksimentievLab·
@KeyserLab @FilipBoskovic12 Somewhere along the way, we observed a rare event: a nucleic acid duplex biting its own tail! Watch the movie to the end. The A-form RNA/DNA duplex was not so hungry:) #Ouroboros
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AksimentievLab
AksimentievLab@aksimentievLab·
Well, this project went from "Which molecule moves faster through a nanopore?" to "What is speed? That is, the answer depends on whether you measure translocation speed in base pairs/sec or nm/sec. Many thanks to @Keyserlab and @FilipBoskovic12 for a wonderful collaboration.
Filip Boskovic@FilipBoskovic12

_1/n Honestly, it has been an incredible experience to scratch the surface of the physics behind our applied work! Building on the work of nanopore crew, we've uncovered some unexpected clues about the electrophoretic translocation of duplexes and how their form affects velocity!

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AksimentievLab retweetledi
KeyserLab
KeyserLab@KeyserLab·
In a study led by @FilipBoskovic12 we examined how the electrophoretic transport of RNA:DNA and DNA through nanopores depends on the contour length rather than the number of base pairs. Nice blend of experiments and simulations! @aksimentievLab @acsnano 🧬🕳️⚛️ @Cambridge_Uni
Filip Boskovic@FilipBoskovic12

_1/n Honestly, it has been an incredible experience to scratch the surface of the physics behind our applied work! Building on the work of nanopore crew, we've uncovered some unexpected clues about the electrophoretic translocation of duplexes and how their form affects velocity!

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AksimentievLab
AksimentievLab@aksimentievLab·
Thank you, Sarthak, for the hooding ceremony and for being such a fantastic student! ⁦@ksarthak71
AksimentievLab tweet media
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AksimentievLab
AksimentievLab@aksimentievLab·
We are looking for postdoctoral researchers to work on the following topics: computational modeling of viruses and organelles, nanopore protein sequencing, DNA nanotechnology, and synthetic cell development. To apply, visit: my.physics.illinois.edu/submit/go.asp?…
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AksimentievLab
AksimentievLab@aksimentievLab·
In partnership with @Sci_Ani, we produced an animation that puts our recent work on genome packaging rdcu.be/dBaXM into a broader perspective. #dna #viruses #highperformancecomputing #tcbguiuc
Science Animated@Sci_Ani

Unlocking the secrets of #viral genomes through computational microscopy offers new avenues for combating #infections. Supercomputers enable virtual reconstruction of virions, shedding light on their molecular programs. bit.ly/3Vfz8PG

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