Andreas Schaefer

Check out our new preprint! Try not to drift off while reading it 💤 biorxiv.org/content/10.648… @AndreasTSchafer (Mihaly not here)

S. Khan et al.: Critical point drying of brain tissue for X-ray phase-contrast imaging #PhaseContrast #XRay #SamplePreparation @TheCrick @EMBLGrenoble @esrfsynchrotron @imperialcollege @ucl... #IUCr journals.iucr.org/paper?S1600577…

This work is the product of an outstanding multidisciplinary team operating across multiple countries. Special congrats to Safe Khan, lead author of the study. And congrats to all authors and supporting institutions! Safe Khan, @AndreasTSchafer doi.org/10.1107/S16005…

#paper: Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬 Safe Khan, @AndreasTSchafer @TheCrick @embl @HiTT_Hamburg @esrfsynchrotron @id16a @imperialcollege @uclnpp

Job alert! Join the Making Lab at the @crick.ac.uk . As a senior engineer in system design, programming, and hardware–software integration, you'll develop systems that make unique experiments possible. More about the role and apply here: crick.wd3.myworkdayjobs.com/External/job/L…

Science is too slow. At Edison, we are integrating AI Scientists into the full stack of research, from basic discovery to clinical trials. We want cures for all diseases by mid-century. We have raised a $70M seed to get started. Join us. We need cracked software engineers who want to work on finding cures rather than selling ads and generating slop. If you’re reading this, you’re probably a candidate. We need brilliant AI researchers who want to figure out how AI will accelerate real-world science. We need scientists and researchers with deep expertise in biology, biotech, and pharma who want to figure out how to integrate AI deeply into scientific workflows, from ideation to experimentation, and how to measure success or failure. We need extraordinarily talented generalist operators across BD, sales, product management, and partnerships who can focus on getting our tools into the hands of pharmaceutical companies. If any of these roles sound like you, get in touch. We are also expanding access to our platform. Our goal is to accelerate science writ large. To that end, we will continue to give academics and students 650 credits/mo indefinitely. I can’t promise we’ll keep this up forever, but we will try. Kosmos will still cost 200 credits, and the other agents (Analysis, Literature, etc.) will cost 1 or 2 credits. All paid users will have access to our regular agents, like our Analysis agent, Literature agent, and so on, for free via the UI. API access will still be paid, and users without a paid subscription will continue to get 10 credits per month for those agents. Our $200/mo subscription for 650 credits/mo is staying in place for now, but might be phased out at our next major product update. Along the lines of accelerating science, we’re also doing a major release of PaperQA today, our flagship open source literature agent, as part of our commitment to open science. In the short run, expect major improvements to Kosmos, including the ability to automatically access data, the ability to steer its exploration, and the ability to converse directly with its world model. In the long run, expect exponentially increasing rates of scientific discoveries, in biology and elsewhere. Our round is led by Triatomic Capital, Spark Capital, and a major US institutional biotech investor. We are also joined in this round by existing investors Pillar VC and Susa Ventures, two exceptional early-stage funds who backed us at founding, along with Striker Venture Partners, Hawktail VC, Olive VC, and a host of exceptional angels that includes famous AI researchers, the CEOs of multiple frontier AI labs, and leadership of major biotech and pharma companies.

My largest investment is @paradromics. We start human trials in Q1. @neuralink has a design flaw which causes tendrils to fall out of the brain. @synchroninc is too slow. All the other brain computer interfaces are toys. Pretty soon, Paradromics will be producing the world’s richest brain data. Then I’ll be richer than @katyperry and producing a documentary on her life.

And coincidentally, my review on synaptic-resolution connectomics came out in @NatRevNeurosci today nature.com/articles/s4158… I emphasize that manual proof reading is (almost) a matter of the past, and that large brains and massive connectomic screening are in reach. 2/3

Connectomics is Method of the Year 2025!! @naturemethods just released the news nature.com/articles/s4159… In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics nature.com/articles/s4159… 1/3

An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @trickymons, @TheCrick, @psich_en, @AdrianAWanner, @AndreasTSchafer, @ucl, @uclnpp nature.com/articles/s4159…

Paradromics Joins Neurotech Race With FDA Nod To Test BCI For Restoring Speech — Click the image below to read more! || #MedTech Insights | Start your free trial today: vist.ly/4gydt vist.ly/4gydu

... but also DM if interested in experimental / computational (or mixed) connectomics postdoc positions

DM me if you are keen to join the team - open positions: (1) computational imaging postdoc: multislice & beyond depth of field reconstructions - crick.wd3.myworkdayjobs.com/External/job/L… (2) experimental, permanent senior scientist: X-ray tomography, EM, sample prep… crick.wd3.myworkdayjobs.com/External/job/L…

X-rays can resolve ultrastructure - a milestone for ultrastructure imaging without cutting. Thanks to an amazing team - @Trickymons @AdrianAWanner Ana Diaz and all collaborators from @TheCrick @psich_en and @esrfsynchrotron and funders @wellcometrust @UKRI_News

The Austin-based startup will test its high-bandwidth device to help restore speech in people with extremely limited movement. wired.com/story/paradrom…

Paradromics is thrilled to share that we’ve received FDA IDE approval to begin a clinical study with the Connexus® BCI. This milestone marks the moment our world-class neurotech moves from engineering into real-world evaluation with people who need it most.

This trial has two goals: ensure the brain implant is safe; and to restore a person's ability to communicate with real-time speech go.nature.com/3XDq9rx

DM as well if you are interested in experimental conectomics postdoc positions

First two positions: (1) computational imaging postdoc: multislice & beyond depth of field reconstructions - crick.wd3.myworkdayjobs.com/External/job/L… (2) experimental, permanent senior scientist: X-ray tomography, EM, sample prep… crick.wd3.myworkdayjobs.com/External/job/L…

Enthusiastic about connectomics and X-rays? Several positions in our group at Crick for postdocs and senior scientists (permanent!). DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today! Please share!