@anshulkundaje So doing a proper multiome GRN analysis and finding key connections and then reinforcing these connections or edges .. would that be a good strategy?
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Sidharth Sen
1.4K posts
Sidharth Sen
@arjunmk1
Lead Bioinfo Analyst at @CincyChildrens , Geek, technophile, Coffee Drinker, AFOL. Works with data integration and multi-omics methods....
Cincinnati, Ohio Katılım Ocak 2009
2.3K Takip Edilen525 Takipçiler
I am sure I have missed many essential items to learn better models of cells. This was not meant to be an exhaustive list. Simply a reality check of how far we need to go before making claims of virtual cells & how our data collection strategies might need to evolve. 28/28
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Great to the see the flurry of single gene knockdown Perturb-seq like atlases from cell-lines, mouse brain etc over the last few days. These are undoubtedly very valuable datasets. I just want to re-iterate a few other very important expt. design considerations 1/
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Lee Grimes Lab@LeeGrimesLab
New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes. With @nsalomonis @morris_lab @BioLegend @CytekBio @NIH @NIDDKgov and tweetless NHLBI and Harinder Singh.
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@riyavsinha @anshulkundaje @jengreitz Perfect I'll take a look. Are you reachable through your GitHub if I have questions in the future?
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@anshulkundaje @arjunmk1 @jengreitz @arjunmk1 yes! the api directly extends the Open Targets api as well. next to the enhancer gene prediction and LD sections, you can view and run the exact graphql queries used to render the pages
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Excited for a major milestone in a collab effort led by @jengreitz to map enhancers & interpret variants in the human genome: The E2G Portal e2g.stanford.edu collates predictions of enhancer-gene regulatory interactions across >1,600 cell types & tissues. Use cases 👇1/
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@ZacksJerryRig @NotaWheelchair Do you guys make a DIY kit? a semi knocked down or fully knocked down kit might be appealing for international buyers...
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Apparently, the USA isn't the only country with wheelchairs that are way too expensive. This guy paid $10,000 in England while my factory can do it here in the USA for less than 1k. Should we start shipping international?
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Thanks to @riyavsinha in my lab, @igvteam browser will natively support dynseq (dynamic sequence tracks) in an upcoming release. These tracks are very useful to directly visualize base-resolution scores (e.g. contribution scores from ML models, conservation etc). 1/
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@DysonProgram @DysonProgram will you guys be releasing the video?? your game music is epic!!
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The concert was a perfect success~(^o^)/~ Thank you all for coming to enjoy the music—and of course, don’t forget to play games with our tunes as your soundtrack.
With the stars as our companions, we journey onward to the next adventure.
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@AdrianoAguzzi yup! about 10 years back went to swiss with parents. Used the 7 day Swiss pass to go around to all the major tourist spots - was amazed how well coordinated the train system was. I still have some those small station specific train schedule booklets....
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The buff is forever..... shameless plug share.google/oH0HPQY4C1pf6R…
USAFVet@BollingerTodd
The B-52 just won't die!
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@Shin01176 @The_Noise_13 They have purple eyes... A couple of YouTubers did an indepth overview of the details in the game. Things is 'purple' doesn't mean bright purple, it can be dark purple and very close to black hence not noticeable.
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The tourist intensifies.
Of all the chaptors the Smurfs actually make sense to be "diversified" as they pull from a whole sector of planets for recruits.
I do think they should've chosen another regiment of Guardsman though. Cadians are overdone at this point and no purple eyes.
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> "I don't know much about lore"
> Complains about black Ultramarines
Why do they take these dumbasses seriously?
🥚@JeanFeliz_
He doesn’t even hide it.
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@brendonboshell @gunsnrosesgirl3 first thing I noticed was the japanese flag on the body of the plane and was like ... hmm pretty sure he's doing point and call.
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@gunsnrosesgirl3 He's doing "point and call" - a Japanese system that reduces mistakes by 85%.
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Plane door close and final checks
twitter.com/visualfeastwan…
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@anshulkundaje And apparently Peter Thiel funded JD Vance ... Looks like it's all coming together for them....
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Future Oligarchs of Trumplandia
David Sacks@DavidSacks
I KNOW A HERO WHEN I SEE ONE The Washington Post names me along with @elonmusk as one of several businessmen who are using their “megaphones” to spread “narratives” about the assassination attempt on President Trump. I’m not sure what “narratives” they’re referring to, but I know what I saw, and I know what the crowd in Butler witnessed live. At it turns out, my father-in-law lives in Pennsylvania and he was at the rally on Saturday. When the shots rang out and Trump went down, he said pandemonium broke out around him. Everyone feared the worst. But then Trump rose. Covered in his own blood, resisting the secret service’s efforts to whisk him away to safety, Trump raised his fist defiantly, and the crowd could see him say: “Fight. Fight. Fight.” Immediately the fear of the crowd dissipated, the chaotic uncertainty lifted, and it was replaced with steely resolve. The crowd responded back as one: “USA, USA, USA!” This is not a “narrative.” It is the truth. Trump stood defiant in the face of an assassin’s bullet. There is no way to fake courage like that. It was more important for Trump to let the crowd know that he was unbowed and unbroken than to be taken to safety. Donald Trump has already been in the fight of his life for months, as vindictive Democrats seek to imprison him, but on this day he came within inches of losing it. He has risked everything for this country. It is now up to us, the American people, to show him that he does not stand alone. Let us reject the lies, the hoaxes, the hate and the division that the media has spread about this brave man, and support his resounding victory in November.
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@aeriflame Villain is forgiven or something due to being misguided/ power of love stuff.
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@aeriflame Super bad Villain is a master of the power the protege and old hero share.
Super bad Villain repeatedly taunts protege to join Villain or give up, etc.
At the end Protege fights Villain and rescues Old Hero.
Old hero sacrifices themselves to kill/subdue the Villain.
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since 10th I've been trying to reconcile my feelings about Homeworld 3, thinking it was just me, my expectations. But to see that the same sentiment is generally the same across the board is kind of incredible. The direction and handling of the story has been a complete misfire.
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