@ManOnThePen Interesting. I am on week 10 of Tirz, up to 7.5mg and already at 9% loss. T2D and obese. was the SURMOUNT-2 trial on a calorie deficit/exercise plan?
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Alex Booth
4.4K posts
Alex Booth
@atalexbooth
I have an unhealthy relationship with music. Tweets are my own opinion
Seattle Katılım Ekim 2009
731 Takip Edilen1.9K Takipçiler
Super helpful info on diabetic weight loss with GLP… hint: we lose a lot less
Jen Can NuSH@JCanNuSH
During my recent discussion with @ManOnThePen , the question of how much weight loss (WL) is typical for T2D patients came up. I've put together a table with this info. Key points to understand: ▪️Pay attention to trial length - longer trials generally lead to better WL results. ▪️T2D trials w/ metformin outperform those w/o ▪️T2D trials tend to have more men than the T2D WL trials, which leads to lower overall performance, as women tend to lose more than men in these trials ▪️Where there are gaps, it's because the manufacturer has not run a trial for that specific dosage or trial type. ▪️For CagriSema, know that when the treatment regimen numbers are finally reported, they will be lower than the efficacy estimand numbers. The treament regimen numbers are the numbers reported in the FDA label, so that's why I focused on those. Reta's TRANSCEND-T2D-1 stands out because that type of study generally has very poor performance relative to the other study types.
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@LadyLibertyinAZ @DrSuneelDhand I was diagnosed with T2D, had high blood pressure, and was mostly sedentary. Getting on Tirzepatide helped me get my body to regulate insulin better, which helps with the weight loss, which helps me get to the gym. Tirz is a speed chute to help with something i needed help with.
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@LadyLibertyinAZ @DrSuneelDhand this is true for some of the populous, certainly. For many, like myself, I'm on a full-blown diet, tracking all my intake, eating in an avg 1800 calorie deficit, aided by tirzepatide, and in the gym 4x a week. I've lost 0.5 lb per day on avg in a little over 2 months.
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The mass prescribing of GLP-1 medications is like watching a slow train crash.
There is absolutely no way this is going to end well.
You cannot solve a lifestyle problem with a hormone-like injection!
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@bschermd I'm using weight watchers combined with Mounjaro for T2D and Obesity. I'm eating in about a 1750 calorie deficit, lifting 3x a week. I'm down 40lbs, 7 weeks on mounjaro, 9 weeks on WW. feeling incredible. BP is way down.
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8/ What’s your experience? Are you getting the support you deserve to restore your long term metabolic health? Drop a comment with your experience below—I’d love to hear your thoughts. ✨ #MetabolicMind #GLP1 #Keto #MuscleLoss #MedicalResponsibility
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1/ New data says we don’t lose excessive muscle on GLP1s. Is it true? Does this change the conversation? I’ve had time to look at the data, and it changes a little, but the overall message remains the same. What do I mean? Let’s talk about it. 🧵
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@MaritzAlston @remarks the most chatgpt response i've ever read. you swapped the -- for ... ugh think for yourself.
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@remarks Not final.
But if it happens?
💰 Major tax shift for cannabis businesses
📉 280E pressure could ease
👉 This isn’t just policy… it’s financial impact.
Watch this closely.
#280E #CannabisTax
Camden, NJ 🇺🇸 English
@brettboettcher1 i've been eating this 5-6 days a week for over two months. Big contriubution to my near 40lbs of weight loss.
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@brettboettcher1 YES dude. This has been the biggest impact on my weight loss.
250g greek yogurt
Protein powder
PB2 pure
Chia seeds
126g Frozen Berry blend (microwaved 45 sec)
1 Banana cut up on top.
65g protein
11g fat
15g fiber
72g carbs
643 calories
SO filling. SO thick. takes a while to eat
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My go-to breakfast takes 2 minutes.
It hits 60g of protein.
And it tastes like dessert.
Here's the Greek yogurt hack:
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@muscleforlife 700 calorie deficit on true maintenance is difficult for someone with previously uncontrolled eating habits, especially when you're gaining, so eating much more than maintenance already. the appetite supression controls the food addiction, allowing me to actually be in deficit.
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Ironic:
Research shows average calorie deficit in GLP1 users is 300-700 kcal/day.
So skipping dessert.
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name a Mariner you enjoyed watching growing up.
I’ll start… GUTI! 👇
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Alex Booth retweetledi
Kid just SMOKED a CNN reporter outside of Artemis II launch:
CNN: "Why do you want to be here?... Why do you love being a part of history?
Kid: "We're going back to the f*cking moon, that's why!" 🤣
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6 months of anxiety starts tonight. Go Mariners.
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Seattle gas prices aren't just about Iran.
In Washington, you’re paying:
• ~$0.74 in taxes
• ~$0.50 from the Climate Commitment Act
That’s ~$1.25 per gallon from state policy alone.
Global oil matters—but so does Olympia. @BobFergusonGov owns part of this.
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@RealPostFolder Living in a city, i'd hire someone to take the ball and put it in the backroom of some sort of repair shop (lots of stock of parts/messy) that I've never been to and just wait it out. That or hand it to a homeless person and hope they forget its in their hoard.
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@GovBobFerguson I mean, bluntly, the people getting "plucked" aren't Americans soo
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I find it deeply un-American that individuals in unmarked cars get out in masks and pluck people off the streets.
When I reflect on the hundreds of bills this session, I am especially grateful that Sen. Valdez's bill to bar law enforcement from wearing masks reached my desk.
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@PNWConservative @GovBobFerguson @washdems yeah i'd rather light $40 on fire before giving to to lil bobby.
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@bkheywood It's an EXCISE TAX for the PRIVILEGE of having snow!
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With all eyes on the income tax that just passed in Olympia you may have missed the Snow Tax SB-0032 that sneaked in at the last minute… as usual eastern washington is going to take it in the shorts…
This morning i woke up to at least $1000 of global warming on the ground in Redmond
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Alex Booth retweetledi
John has an interesting take on how to cope with Washington's income tax.
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