EJ Gibson

80 posts

EJ Gibson

EJ Gibson

@avhoeck

Katılım Şubat 2014
0 Takip Edilen67 Takipçiler
EJ Gibson retweetledi
Sylvie Noordermeer
Sylvie Noordermeer@SylvieNoorderm1·
Excited to share with you the first manuscript of the lab! Here, we describe a novel synthetic lethal interaction between BRCA1-deficiency and EXO1 loss. (1/7) biorxiv.org/content/10.110…
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EJ Gibson
EJ Gibson@avhoeck·
So glad to see you found a nice environment in Barca to continue your research as PI in cancer genomics. Many congrats!! Looking forward to your future projects with your friends at @HartwigMedical.
Francisco Martínez-Jiménez@fran_mj88

Thrilled to announce that today I begin a new chapter as Junior Group leader at the @VHIO in Barcelona. My team will work in close collaboration with the @HartwigMedical studying multiple facets of tumorigenesis and its interplay with the immune system 1/4

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EJ Gibson retweetledi
Nature Portfolio
Nature Portfolio@NaturePortfolio·
Anti-cancer therapies are highly mutagenic to cancer cells but the mutational impact on healthy tissues remains elusive. A study in @NatureComms characterises somatic mutations in healthy colon and liver adult stem cells after chemo- or radiotherapy. go.nature.com/3T7QWs9
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IberianCitizen
IberianCitizen@IberianCitizen·
Si bien ls quimioterapias son altamente efectivas xa matar las células cancer osas, su uso sistémico tb aumenta la carga mutacional d las células madre normales responsables d la renovación dl tejido, lo q aumenta el riesgo de desarrollar segundos cánceres doi.org/10.1038/s41467…
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EJ Gibson retweetledi
Eytan Ruppin, MD, PhD
Eytan Ruppin, MD, PhD@EytanRuppin·
Systemic chemotherapies use increases the mutational burden of long-lived normal stem cells responsible for tissue renewal, thereby increasing the risk of developing second cancers. nature.com/articles/s4146…
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Anirban Maitra
Anirban Maitra@Aiims1742·
Interesting study from @ecuppen & @avhoeck (some surprising, others not so surprising results!) in @NatureComms: Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue nature.com/articles/s4146… All adult stem cells (ASCs) or ChemoRx are not the same!
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EJ Gibson
EJ Gibson@avhoeck·
The mutational impact 🧬of standard chemotherapies 💉💊 in healthy tissue is tissue-type specific!! ⚠️Now online at rdcu.be/cW5vk⚠️ Together with @ewartkuijk and @ecuppen @UMCU_CMM @Cancer_UMCU @oncodeinstitute
Nature Communications@NatureComms

@ewartkuijk @ecuppen @avhoeck et al. analyse #SomaticMutation patterns induced by anti-cancer #therapies in adult #StemCells from healthy colon and liver using #organoids and #WholeGenomeSequencing #CancerResearch #AdultStemCells @natrescancer go.nature.com/3fPP5tw

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EJ Gibson
EJ Gibson@avhoeck·
Novel insights on the mutational impact of DNA hypomethylation. Great study from @ewartkuijk
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EJ Gibson retweetledi
Francisco Martínez-Jiménez
Francisco Martínez-Jiménez@fran_mj88·
⚠️⚠️Amazing paper alert⚠️⚠️ Machine learning-based classification of tissue of origin for cancers of unknown primary based on whole-genome features. >90% sensitivity and specificity and highly informative feature explanation. Take a look at the tweetorial and the manuscript👇👇
Luan Nguyen@luannnguyen0

Our paper titled “Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features” is now online in @NatureComms! @avhoeck @ecuppen nature.com/articles/s4146… Check out the tweetorial below:

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EJ Gibson
EJ Gibson@avhoeck·
Our work on CUP detection now online. CUPLR, developed by @luannnguyen0, detects prim tumor type from WGS data. WGS-based DNA tests with CUPLR will improve diagnostics for cancer patients whose primary tumor is unknown, which is reimbursed in 🇳🇱 for these patients. @ecuppen-lab
Luan Nguyen@luannnguyen0

Our paper titled “Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features” is now online in @NatureComms! @avhoeck @ecuppen nature.com/articles/s4146… Check out the tweetorial below:

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EJ Gibson retweetledi
Hartwig Medical
Hartwig Medical@HartwigMedical·
Great news! We are proud to have been able to contribute to this study with our Hartwig Medical Database. Do you want to use this data, too? bit.ly/3xAyKOg #personalizedtreatment #cancerresearch #cancergenomics
Francisco Martínez-Jiménez@fran_mj88

How genomically different are early stage primary tumors and late stage metastatic tumors? Check out our latest work “Pan-cancer whole genome comparison of primary and metastatic solid tumors'' 🧬💻. Main findings and conclusions 🧵👇 biorxiv.org/content/10.110…

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Anirban Maitra
Anirban Maitra@Aiims1742·
The metastatic cohort data is via the Hartwig database (see Dr. @ecuppen tweetorial linked below). An incredible freely available resource for the cancer research community.
Edwin Cuppen@ecuppen

Pleased to announce our novel catalog interface of the Hartwig database with whole genome sequenced tumor genomes: catalog.hartwigmedicalfoundation.nl. Currently more than 5,000 patients, including treatment and response data. Plus RNA-seq data for more than half of the patients.

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