Brandon Conaway, PharmD

In conclusion, aPTT are more common due to availability and cost, however, anti-Xa levels have benefit in monitoring anti-xa inhibitors for suspected non-compliance and prior to surgery.

A study by Berger et al. showed that morbidly obese patients (BMI > 40) had supratherapeutic anti-Xa levels when using standard 1 mg/kg enoxaparin dosing. On average, bleeds occurred in those with a higher BMI, but a correlation was not made due to small sample size.

Earlier this year, I had the pleasure of presenting a CE on comparing the safety and efficacy of Anti-Xa and aPTT in monitoring anticoagulants — Here are some highlights!