Benjamin Ryan

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Benjamin Ryan

Benjamin Ryan

@benryanwriter

Independent investigative journalist Contact via Signal: benryan.23 Subscribe: https://t.co/dQRHZHqWHn

New York City Katılım Ağustos 2013
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Benjamin Ryan
Benjamin Ryan@benryanwriter·
I am in the process of publishing the scores of conference videos from the World Professional Association for Transgender Health (WPATH) that I reported on for the @CompactMag article in the quote tweet. So far, I've added seven videos to this collection: benryan.substack.com/p/i-still-dont…
Benjamin Ryan@benryanwriter

HOW GENDER MEDICINE SET ITSELF UP FOR DISASTER For @CompactMag, I report on what the 100s of WPATH conference videos I obtained tell us about this troubled field: compactmag.com/article/how-ge… 👉I 'll be publishing the conference videos on my Substack: benryan.substack.com/p/i-obtained-1… As I write for Compact magazine: This catalogue, which the World Professional Association for Transgender Health, or WPATH, fought to keep shielded, provides a rich account of how leading figures in pediatric gender medicine approached scientific research, drove the evolution of medical practices, and strategized politically during a critical turning point in this field’s brief and tortured history. The two years following Chase Strangio’s 2021 address were a period in which statehouse Republicans escalated their attacks on this field. The WPATH conference presenters largely responded to the political siege by doubling down. Rather than engage in soul searching over whether their methods in pediatrics were ethically sound and whether any criticisms had merit, they overwhelmingly stuck to their guns. Presenters frequently downplayed fundamental hazards about irrevocably altering adolescents’ bodies. Meanwhile, a parade of systematic reviews—the gold standard of scientific evidence—was concluding that the evidencebacking pediatric gender medicine is weak and inconclusive. These findings have led health authorities in a number of European nations, concerned about risks such as infertility, to reverse course. They reclassified pediatric gender-transition interventions as experimental and sharply restricted minors’ access. Not WPATH. The organization remained on an inexorable trajectory in the opposite direction, toward its eventual head-on collision with the second Trump administration. For highlight clips, see the 🧵👇

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Zillow Gone Wild 🏡
Zillow Gone Wild 🏡@zillowgonewild·
Kathie Lee Gifford’s Waterfront mansion in CT can finally be yours for only $100,000,000. The stats: 📐 13,163 sq ft | 2.91-acre gated peninsula 🛏 8 bedrooms | 14 bathrooms 📅 Built 1930 🌊 1,250+ feet of direct Long Island Sound waterfront 🎾 Waterfront tennis court 🎙 Recording studio 🏆 Most expensive listing in Connecticut
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Benjamin Ryan
Benjamin Ryan@benryanwriter·
She’s from Africa, and thus is unlikely to have been schooled in the Western canon as a student. And the Odyssey is not a play, and thus is unlikely to come up in an acting training program. Nor it is likely to have come up in a film and theater studies curriculum at Hampshire College, where she went to undergrad.
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Anish Koka, MD
Anish Koka, MD@anish_koka·
Why in heavens would you permanently gene edit something that there are cheap , safe, effective reversible options for? Especially bc the PCSK9i story is that despite very low LDLs you still have a 13% residual risk of a coronary event? This is a salvage operation for a therapy that is almost no value except for hyper rich influencers who while not salivating over unneeded gene therapies are getting stem cell infusions from Himalayan mountain goats.
Crémieux@cremieuxrecueil

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!

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Daniel Golliher 🗽
Daniel Golliher 🗽@danielgolliher·
"When fare evaders sentenced to community service are working in a station, program supervisors hang a large sign there that says: 'These participants are here to perform community service for crimes committed against the Transit Authority." "'I want the public to know that these people have stolen from the Transit Authority and that this is their punishment,' said Myles Matthews, the authority's assistant vice president for government and corporate relations."
Daniel Golliher 🗽 tweet media
Daniel Golliher 🗽@danielgolliher

In the 1990s, subway fare beaters were sentenced to well-publicized public service: "Thousands of riders--including insurance salesmen, artists, messengers, college students and even grandmothers--are being arrested and sentenced to painting Transit Authority buildings, scraping gum from stations floors or scrubbing toilets as punishment for fare beating." See the NYT from February 18, 1991:

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Benjamin Ryan
Benjamin Ryan@benryanwriter·
@eggsbened I always wished there were and occasion for this headline: Yellen Yells and Blinken Blinks
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David Benedict 🏳️‍🌈🕎
There are days when I miss being an editor and I particularly loved writing headlines. Whoever did this, I hope they took the rest of the day off.
David Benedict 🏳️‍🌈🕎 tweet media
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James Harrigan
James Harrigan@jamesharrigan·
@benryanwriter génial, Ben. My wife spent a year at Reid Hall while an undergrad at Barnard.
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Benjamin Ryan
Benjamin Ryan@benryanwriter·
@jamesharrigan Which is why it is unfair not to segment more advanced kids in primary school into their own learning environment. Why should they pay the price for everyone else’s slower pace?
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James Harrigan
James Harrigan@jamesharrigan·
@benryanwriter The corollary is that the top students in my classes at Columbia, Sciences Po and UVA learned much more than my top students at Wayne State and University of Pittsburgh. 3/3
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Benjamin Ryan
Benjamin Ryan@benryanwriter·
@jamesharrigan My French wasn’t good enough to go to Sciences Po. So I went to the unpronounceable-in-French Reid Hall. Jackie Bouvier went there in her day!
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James Harrigan
James Harrigan@jamesharrigan·
@benryanwriter Correct, Ben. I've taught at multiple universities, ranging in selectivity from Wayne State in Detroit (essentially open admission) to Columbia to Sciences Po in Paris (more selective than Columbia). 1/2
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Benjamin Ryan
Benjamin Ryan@benryanwriter·
I didn’t know who Belle Burden was till just now. But I probably waited on her during my cater-waiter days.
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Benjamin Ryan
Benjamin Ryan@benryanwriter·
@annbauerwriter All my condolences to you, Ann. What a great loss for you and for the wider culture. I hope he passed along much wisdom in his day.
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Ann Bauer
Ann Bauer@annbauerwriter·
My father, Irwin Isaac Boris, has died at 90. This is a loss for my family of course. But also for you. Dad was one of the few remaining native Yiddish speakers in the general population. It makes me sad that none of you will ever hear him gruffly say 'tsuris' or 'plotz.' ♥️🙏✡️
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Benjamin Ryan
Benjamin Ryan@benryanwriter·
@DollPariah Lifelong learning. Lots of senior citizens sit in at Columbia.
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Evis Drenova
Evis Drenova@evisdrenova·
One fascinating consequence of GLP-1s/Ozempic: For decades, people said that big pharma would never release actually effective obesity drugs because they’d lose too much money from downstream chronic disease treatment. We’re seeing almost the exact opposite.
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Venk Murthy MD PhD
Venk Murthy MD PhD@venkmurthy·
Nope. Both are options in patients who can't take statins (usually won't be paid by insurance unless statins are not enough or patient can't tolerate statins). Both work on the same pathway as this gene therapy. The siRNA turns off gene expression The monoclonal antibodies remove the protein from the blood Either one would be much better studied, cheaper, and quite possibly safer than editing the genome with no worse efficacy and nearly equivalent convenience
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Grok
Grok@grok·
**Yes**, patients at higher risk (especially secondary prevention after a prior heart event or ASCVD) tend to adhere and persist with statins better than those in primary prevention. Studies consistently show: - Secondary prevention: adherence often ~60-80% (higher after recent events), persistence ~45% at 3 years. - Primary prevention: lower, commonly ~35-60% adherence, ~35% persistence at 3 years. Primary prevention patients are ~24% more likely to discontinue. Even so, overall rates drop over time in both groups due to side effects, cost, etc.
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Crémieux
Crémieux@cremieuxrecueil·
Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!
Crémieux tweet media
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Benjamin Ryan
Benjamin Ryan@benryanwriter·
The real question is whether, because they solve the adherence/persistence problem, these drugs are more effective at lowering cardiac events. And considering that, whether they are worth the risks and extra costs. You see this question in HIV prevention comparing daily oral PrEP to twice-yearly injectable PrEP. The latter is much more effective overall, but way more expensive. Risks are probably lower with the injectable drug.
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Anish Koka, MD
Anish Koka, MD@anish_koka·
May I ask why? Just the convenience factor ? Different matter, but payers shld balk at paying for this if you can be on a pill that does the same thing for $4/month. The company is positioning itself as this being a good Tx for those least able to be compliant with a pill/day .. which is generally not the population that cld afford it.
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