Wade Davis

We're excited to present our latest data at #IDWeek2021. Findings show that mcfDNA detected #fungal infections prior to onset of symptoms in children with #leukemia, also co-pathogen detection of #Aspergillus, #Mucorales, #PJP by the #KariusTest. Join us! bit.ly/39QY7Qy

@yudapearl What about meta-analysis and estimation of the distribution of effect sizes based on random effects model? Not typically used to do so, but you could use that information to attach probabilities to a range of effect sizes of a future study under some assumptions

Put another way, the language of standard statistics does not allow us to take experimental findings from past studies and leverage them to draw conclusions about effect size in a new study. Curious: Does Evidence-Based methodology offer such a language?

We're thrilled to release a manuscript on rare variant association testing on the exomes of 300k individuals in the UK Biobank medrxiv.org/content/10.110… and a browser of the results: genebass.org

There's another job opening in my department! Please follow up with me if you are interested or know a good candidate! #hiring #jobs #bioinformatics #abbvie #pharma careers.abbvie.com/abbvie/jobs/21…

@hal_ashton Are talking about noticing something more or actually discovery? Baader-Meinhof? google.com/amp/s/thenewsw…

@Lindsie_Rose 45 and we were doing 15 ft ropes outside in 2nd grade, just for fun not required. No harness. No mats. Just dirt to break your fall. How did you get back down? slide back down with loose grip. Lots of rope burn though.

I also might need you to follow up with your age if you did bc I'm wondering if younger generations didn't do it?

Did people actually climb ropes in gym class or is that just a movie/tv trope?

@AsraNomani @yudapearl @GovChristie @jaketapper Heartbreaking. CNN clip didn’t give reason Pakistan would suddenly release the perpetrator? I didn’t know some of the details shared in the clip, but how a human could do this to another human & their family is shocking.

Thank you @GovChristie and @jaketapper for being voices for dear Daniel Pearl. 19 yrs ago today, he was a gleeful expectant father. World: Pls raise your voice with your govt officials to help Ruth + @yudapearl realize #JusticeforDanielPearl. Supreme Court case restarts Jan 5.

SRA plans to drop base quality. This would make resequencing data largely useless for var calling. There are better ways to save space: quality binning and CRAM. If you use reseq data from SRA, please voice yourself in this RFI (deadline in 2 weeks): datascience.nih.gov/sra-rfi-submis…

Excess deaths track reported COVID-19 deaths in Cook County, IL. The reported deaths, 860, are about 80% the actual cases, with this proportion trending towards 100%. We show data for Cook because, AFAIK, it is the only jurisdiction making up-to-date death registry data public.

If more scientists calculated confidence distributions, they would realise that a point estimate is a value in which you have zero confidence.

Our latest using single-cell ATAC-seq and HiChIP to identify putative functional risk loci in Alzheimer’s and Parkinson’s disease. This was an amazing collaboration between @HowardYChang @anshulkundaje @sbmontgom and the twitterless Tom Montine. biorxiv.org/content/10.110… 1/n

Ultra-high throughput scRNA-seq from Christoph Bock's lab! Combines combinatorial barcoding with droplet microfluidics to sequence >150,000 cells on a single @10xGenomics lane: biorxiv.org/content/10.110…

StringTie2 paper is out: more accurate than any other RNA-seq assembler, even faster than before, and now able to handle ONT and PacBio reads, where it's significantly more accurate and 80 times faster than the next-best method. s/o @elapertea @samkovaka genomebiology.biomedcentral.com/articles/10.11…

Our paper on using human genetics to predict drug program success is out! eurekalert.org/pub_releases/2… journals.plos.org/plosgenetics/a…

@JBlevins0 @lpachter Wald

Long read sequencing of 1,817 Icelanders provides insight into the role of structural variants in human disease disq.us/t/3js36pw

This demonstrates beautifully the transformative value of studying consanguineous populations for finding human knockouts. Same discovery power with <1% the sample size.

Washington University in St. Louis to be free for low-income Missouri, southern Illinois students chicagotribune.com/midwest/ct-was…