@BrainComms

Have you read an outstanding paper published in Brain Communications during 2025? Take note of it for the Early Career Researcher Paper Prize! Nominations are Open! #ecr #paperprize #neuroscience Link to form: buff.ly/8DWT8TV Find out more at: buff.ly/5WfBuCR

Giudicessi et al. report that females with inherited early-onset Alzheimer’s disease carrying the presenilin-1 mutation show preserved brain connections & slower decline, whereas males rely more on these connections to support memory. 👉 doi.org/10.1093/brainc…

Wang et al. demonstrate that ertugliflozin ameliorates core autism-like behaviour in BTBR T + Itpr3tf/J mice, improving social interaction while reducing repetitive behaviours and anxiety. Read it at 👉 doi.org/10.1093/brainc…

Xu et al. report that cerebral small vessel disease burden and plasma p-tau181 synergistically affect white matter microstructure and cognition in a Chinese cohort. The findings highlight a synergistic interaction between vascular and tau pathologies. 👉 doi.org/10.1093/brainc…

Timmsen et al. use functional brain imaging to show that stroke survivors can still acquire new motor skills, but the supporting brain activity differs from healthy individuals, suggesting alternative neural mechanisms compensate after stroke. 👉 doi.org/10.1093/brainc…

Meet Dr Susan Jones, an Associate Professor at the University of Cambridge 👋 Her research explores how neurons communicate through electrical and chemical signals, and how these change during brain plasticity, development, and neuropsychiatric disorder models. #meettheteam

Sastre-Bataller et al. reported that high-intensity focused ultrasound thalamotomy provides sustained tremor control across essential tremor (ET) phenotypes with minimal impact on gait and balance. Read it at 👉 doi.org/10.1093/brainc… #neuroscience #braincommunications

Kassinopoulos et al. show that amyloid-β pathology in cognitively unimpaired individuals is associated with regional grey matter volume increases, with diffusion MRI implicating neuroinflammation-related cellular complexity or glial remodelling. 👉 doi.org/10.1093/brainc…

Koenig et al. report that p-tau217 and glial fibrillary acidic protein (GFAP) levels in plasma are linked to hypometabolism on [18F]Fluorodeoxyglucose PET and brain atrophy in neocortical association regions affected by Alzheimer’s disease. Read it at 👉 doi.org/10.1093/brainc…

McGinnis et al. show that ex vivo human brain organotypic slice cultures preserve major cell-type transcriptional identities for two weeks, providing a robust human CNS model for mechanistic studies and therapeutic screening. 👉 doi.org/10.1093/brainc… #neuroscience

Kim et al. report early (<1 month) functional disconnection between the default mode network and attention-related networks in mild traumatic brain injury, despite relatively stable structural connectivity. 👉 doi.org/10.1093/brainc… #neuroscience #braincommunications

📢 Attending FENS Forum 2026? Want to learn more about Brain Communications? 🧠 Don't miss the chance to meet our new Editor-in-Chief, David Belin, as well as our former Editor-in-Chief, Tara Spires-Jones, and some of our Associate Editors! Let us know if you'll be there👇

Meet Dr Tristan Hynes, an Assistant Professor of Psychology at Simon Fraser University in Canada 👋 His work examines the neurobiological mechanisms underlying addiction and maladaptive reward-seeking behaviour. #neuroscience #braincommunications #meettheteam

📣 Welcome to Volume 8, Issue 4 of Brain Communications! We are delighted to share that our latest issue is now live! 🧠 Explore the latest issue here: academic.oup.com/braincomms/iss… Cover image courtesy of Chloe Chernoff and David Belin, University of Cambridge. #neuroscience

Alyahya et al. provided empirical validation for a time-efficient & clinically applicable approach to measuring content word fluency (CWF). Lesion correlates in left frontal & parietal regions related to impaired CWF during spoken discourse in aphasia. 👉 doi.org/10.1093/brainc…

Lora et al. reported that repeated low-intensity blast exposure in Special Operations Forces was linked to increased frontal-predominant tau deposition using PET and elevations in plasma biomarkers of astroglial and neuronal injury. 👉 doi.org/10.1093/brainc… #neuroscience

Chai et al. report that higher serum inflammasome adaptor protein ASC were associated with vascular cognitive impairment and dementia, which may be largely mediated by concomitant cerebrovascular disease, specifically white matter hyperintensities. 👉 doi.org/10.1093/brainc…

Huang et al. report that by integrating prenatal and postnatal data, they identified significant genetic heterogeneity, phenotypic complexity and challenges in prenatal diagnosis for lissencephaly. Read it at 👉 doi.org/10.1093/brainc… #neuroscience #braincommunications

Lu et al. thoroughly described EEG features in people with new-onset epilepsy in elderly ages, using EEG from 24-h monitoring. They found special slowing and epileptiform patterns in temporal regions, which were associated with cognitive impairment. 👉 doi.org/10.1093/brainc…

Meet Professor Jean-Luc Houeto, Coordinator of the Parkinson’s Centre at the Centre Hospitalier Universitaire de Limoges in France 👋 His research focuses on movement disorders, including efficacy of treatments such as deep brain stimulation for Parkinson’s disease.