jay brophy

A slightly longer version (4 min read) of my take on the new revascularization guidelines as they pertain to LM disease can be found here brophyj.com/post/2021-12-1… @VictorDayan1 @kaulcsmc @drjohnm @DavidLBrownMD

@DrToddLee @drjohnm @theheartorg Why would anyone be surprised? 27years ago a RCT of nearly 7000 patients found data compatible with a possible 9% mortality reduction CI .91-1.07 & hospital decreased 28% CI 0.66 to 0.79

@drjohnm @theheartorg @brophyj

Darn it. There’s no editorial. Why? Because the heart failure community is stunned. They are speechless. No worries. You can read this (slightly biased) editorial for free on @theheartorg medscape.com/viewarticle/fi… #esccongress #esc2025

Good bye X, hello BlueSky!

@FAircanada46710 So it goes bad to worse. The lineup for the AC lounge, included rather worthlessly with the purchase our business class tickets, is more than 1 hour. Needless to say will find other eateries.

So AC e boarding downloads still not working. They don't seem to really care. Looks like I'll need a printer to board later today. Thanks for the lack of help. @AirCanada

@AirCanada Perhaps AC would like to me to try later AFTER my flight has departed!

@ASayedMD This was amazing work by you from conception, through analysis to submission. Congratulations!

Immensely grateful for @brophyj for his generous guidance, encouragement, and patience on this project🙏🙏🙏 All the code is provided freely on GitHub. The "qmd" document contains the R code and the "html" document contains the table/figure + code: github.com/ahmedsayedcard…

Happy to publish our analysis of Bempedoic Acid in 1ry versus 2ry prevention @IJCardio Link 👇 internationaljournalofcardiology.com/article/S0167-… A 4-part 🧵 1) Unlike 1ry prevention, where the observed mortality reductions were impressive, there was a signal of increased mortality in 2ry prevention

@DrToddLee @FralickMike @GIMtoronto Hopefully will be submitted within the next 2 weeks

@FralickMike @GIMtoronto @brophyj I don't think the Canadian RCT is published yet

One pager on a handful of non-antibiotic meds we prescribe often on GIM. feedback welcome. 🤓 @GIMtoronto if you want to learn more about SGLT2 - sglt2rx.com [needs some updates, i know]

@kaulcsmc Desk reject in all cases, doesn’t meet our priorities, see yeah later. And oh by the way, good luck and look forward to other submissions from you in the future

@brophyj Excellent and thought provoking, as always! Are you able to share the key points raised in their critique/peer review by journal editors/reviewers so that we can judge if their arguments have any merit?

First time publishing on Medium @jbrophy115/is-science-really-self-correcting-64b829ec7935" target="_blank" rel="nofollow noopener">medium.com/@jbrophy115/is…

Just my 2 cents, but 👎👎👎to the new @Twitter name and logo

New @nejm study nejm.org/doi/full/10.10… median 5.1 years MACE = 4.81/1000PY in #pitavastatin and 7.32/1000PY in placebo. Text claims 5 year NNT = 106. What am I missing? Looks like 5 year NNT = 1/(7.32/1000-4.81/1000) = 398 to me. Statistically significant but clinically?

Sad day - my old friend towed way to its demise. But broken power steering, gas leak requiring open windows, battery needing constant jumping, slow tire leak, and the family of mice living in the trunk, just added up to too much. Last drive yesterday, 20 years was a good run!

@drjohnm @f2harrell @kaulcsmc @beenwrekt @VPrasadMDMPH “Reporting the LR may improve the interpretation of clinical trials” I don’t think so. Large LR mostly showing overly enthusiastic Ha being proposed. To assess how much support exists for the null (+/- range of equivalence) need the full probability distribution @arthur_alb1

Wow. I love this paper. Thx Dan. But is it not darn close to calculating a Bayes Factor? Which seems highly useful. And not just DIY stats. Hope the experts will weigh in. Paging @f2harrell @kaulcsmc @brophyj @beenwrekt @VPrasadMDMPH

Another image from early am run

No phone with me, so this is the best I can do to show the beauty of an early morning country run.

Have a short article deals with teaching, research, biases, critical reading, and foundational past research. No natural home and no interested publisher. So 1st use of medium.com @james.brophy/something-old-and-something-older-beware-of-looking-into-the-future-5087cd89ff73" target="_blank" rel="nofollow noopener">medium.com/@james.brophy/… Also available on my webpage brophyj.com/post/2023-03-2…

@DrToddLee @kaulcsmc Ignore the results for a moment. A priori, do you think in NA context, equipoise existed to do this trial? We know this drug makes you bleed and in the context of recent stroke…. I certainly would never have participated.

@kaulcsmc "Results for secondary end points were generally not consistent with the results of the primary analysis" Never seen someone just own it like that.

1/ Tirofiban revisited! Tirofiban+ ASA (n=604) vs ASA (n=567) in ischemic stroke without occlusion of large or medium-sized vessels PEP (score of 0 or 1 on the modified Rankin scale): 176 (29.1%) vs 126 (22.2%), RR 1.26, 1.04-1.53, p=0.02 nejm.org/doi/full/10.10…

@DrToddLee @robyn_s_lee So sorry Todd. My profound condolences on your loss.

The disease took you from us long ago but having you leave forever makes it real. Thank you for being an amazing mother and forever an inspiration of how to treat other people. I'm still trying my best, mom. @robyn_s_lee

@f2harrell @VPrasadMDMPH ChatGPT no better - how to interpret - RR 1.01, 95% CI 0.72-1.42? “RR= 1.01 means no significant Δ in the outcome between intervention & control group. The 95% CI range indicates that we are 95% confident that the true effect of the intervention lies somewhere within that range."

I am very disappointed to see such an un-nuanced interpretation of wide confidence intervals from @VPrasadMDMPH who should know better. Wide intervals are widely interpreted as the study being uninformative whether it's about masking or not papers.ssrn.com/sol3/papers.cf…