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New paper from the lab: "Asynchronous firing and off states in working memory maintenance"
sciencedirect.com/science/articl… (1/10)
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Christos Constantinidis
2K posts
Christos Constantinidis
@c_constan
Professor of Biomedical Engineering and Neuroscience. Neural basis of cognition, cognitive development, deep brain stimulation.
Nashville, USA Katılım Ekim 2010
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Christos Constantinidis retweetledi
New paper!
Deep-learning-assisted simulation of a cortical circuit:
integrating anatomy, physiology and function
biorxiv.org/cgi/content/sh…
It comes with a new major model release from @AllenInstitute.
Find models and code here: github.com/AllenInstitute…
🧵
1/13
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Christos Constantinidis retweetledi
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s41593…
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@ericg_ceballos curates an atlas of neuropeptide receptors and relates it to brain function @NatureNeuro 🧩 🧠 ⤵️
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Very happy to announce that my student Zhengyang Wang successfully defended his PhD dissertation today. Congratulations Dr. Wang!
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Christos Constantinidis retweetledi
Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain.
@hhmi_science
#Neuroscience #BrainPrize2026
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Christos Constantinidis retweetledi
We’re hiring! 🚨 My lab at Vanderbilt is looking for a Research Assistant to study how touch & pain circuits develop and function. 🧠✨
Please help me spread the word! 😀
ecsr.fa.us2.oraclecloud.com/hcmUI/Candidat…
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Christos Constantinidis retweetledi
1/2 New paper supporting a 4-factor model of Executive Functions in nonhuman primates (NHPs) using a multi-task assessment approach. NHPs show consistent cognitive phenotypes: A first step quantifying the cognitive architecture in NHP biorxiv.org/content/10.648…
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Christos Constantinidis retweetledi
Together, our work demonstrates how brain-like structure shapes functional organization and enables function to be discovered from the structure, highlighting the potential of structurally grounded artificial intelligence for neuroscientific research.
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Christos Constantinidis retweetledi
Fourth, we found that structural constraints render functional organization directly inferable from structure. For example, structural constraints align functional modules with structural network modules.
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Christos Constantinidis retweetledi
Third, we found that canonical macroscale principles linking structure and function in the human cortex, including structure–function coupling, functional modules, and functional gradients, emerge along the topographic and topological organization of BrainRNNs.
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Christos Constantinidis retweetledi
Second, we discovered under these structural constraints, BrainRNNs selectively regulate distribution of connectivity and increase activated association units for higher-order cognitive capacity.
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Christos Constantinidis retweetledi
First, we introduced a brain-like recurrent neural network (BrainRNN) that integrates comprehensive structural constraints inspired from the macroscale human cortex.
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Christos Constantinidis retweetledi
Can functional organization be inferred from structure in artificial neural networks, as is commonly done in neuroscience? We introduced BrainRNNs to answer this question.
biorxiv.org/content/10.648…
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Christos Constantinidis retweetledi
Introducing NeuroSTORM, a foundation model for fMRI. Pretrained with 28.65 million fMRI frames (>9,000 hours) collected from over 50,000 subjects, spanning multiple centers and covering ages 5 to 100.
arxiv.org/abs/2506.11167
github.com/CUHK-AIM-Group…
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Christos Constantinidis retweetledi
Exciting new preprint out led by @JingwenLi18. The paper describes the first recordings of V1 neurons in a freely-moving monkeys and how dynamic active gaze behaviors organize visual input in the real-world. Amazing work from a rising star! biorxiv.org/content/10.648…
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Final funding amounts of US research agencies enacted into law by Congress for Fiscal Year 2026 relative to what the President's budget requested
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Christos Constantinidis retweetledi
The new @NIH SciENcv Biosketch pissed me off so much today (lost 4 hours of my life) that I built a quick NIH Biosketch format converter. It lets you format each section while seeing both the preview and the HTML code at the same time.
It restored my sanity, a little.
Enjoy.
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Christos Constantinidis retweetledi
Christos Constantinidis retweetledi
Redundant prefrontal hemispheres adapt storage strategy to working memory demands
doi.org//10.1101%2F202…
#neuroscience
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New NIH biosketch forms delayed:
"NIH will provide a warning when the Common Forms are not used but will not withdraw applications that don’t comply with the use of the Common Forms. We expect the leniency to be in place through May 2026" grants.nih.gov/faqs#/common...
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