Calico

Learn more in this video, and access trial information here: anchoradpkd.com #NationalKidneyMonth (5/5)

During National Kidney Month, we’re sharing how our research continues to deepen the understanding of how ADPKD progresses and the biology behind it. We are translating these insights into a global Phase 2 clinical study in adults with ADPKD. (4/5)

Autosomal dominant polycystic kidney disease, or ADPKD, is the most common inherited form of kidney disease worldwide. (1/5)

We wouldn’t be where we are without our team. We’re honored to work with some of the most dedicated, curious and creative colleagues who share our commitment to understand aging and improve healthspan. Here’s to another year of advancing science! #EmployeeAppreciationDay

Our 4th annual Hack Week brought together colleagues to think creatively and explore new ways of working with data. Prior Hack Week projects have helped inform new computational science direction for Calico, and we look forward to seeing where these new ideas lead!

Astrid will present more about this work during her keynote speech at the upcoming Biology of Acute Respiratory Infection Gordon Research Conference. #AgingResearch (5/5)

By targeting these immune cell interactions, we’re working to enhance lung repair and restore function, with the goal of translating those findings into potential interventions for age-related lung diseases. (4/5)

As the lung ages, its capacity for self-repair diminishes. Our scientists are working to understand this process. Using tissue clearing and light sheet microscopy, Agnieszka (Anya) Wendorff in the Gillich Lab and Kayley Hake visualized a whole aging mouse lung in 3D. (1/5)

Congrats to Calico CSO, Michael Lenardo, M.D., for being named a 2026 Distinguished Fellow of the American Association of Immunologists (AAI)! The designation recognizes a career of contributions to immunology, scientific leadership, and long-term service to the field.

Happy Int’l Day of Women and Girls in Science! We asked four of our Calico colleagues: What excites you most about a career in science? #InternationalDayOfWomenAndGirlsInScience #WomenInScience #ScienceCareers

In TIME’s new Longevity series, Cynthia Kenyon, Ph.D., VP of Aging Research, reflects on how her early research helped redefine the study of aging, and how that work continues to guide efforts to connect foundational research to real-world human impact. time.com/collections/fu…

Our Summer Internship Program applications are now open! If you’re a student who is eager to learn more about aging biology, check out our opportunities here: calicolabs.com/careers/. To learn more, attend a virtual info session: forms.gle/f2LweDErpciwsY…. #ScienceInternships

Today, Calico has five assets in clinical development and more than 20 early-stage programs, with the flexibility to advance them on our own or with collaborators who share our mission to help people lead longer and healthier lives. Read the interview: nature.com/articles/d4157…

Over the past 12+ yrs, we’ve built deep capabilities in the biology of aging, created platforms drawing on large human data cohorts, and advanced computational power. We’ve used this foundation to map aging pathways, identify druggable targets, and advance new therapeutics. (2/3)

In a new Nature Reviews Drug Discovery Q&A, our Head of Drug Discovery, Philip Kym, PhD, talks about how Calico is turning insights about aging biology into potential new first-in-class medicines. (1/3)

This level of speed and resolution reveals dynamic cellular processes that would otherwise be invisible using other microscopes, offering insight into how changes in organelle function may contribute to the cellular decline associated with aging. (4/4) #AgingScience

Labeled with fluorescent markers are three of those key compartments: • Green: inner mitochondrial membrane • Red: endoplasmic reticulum • Purple: lysosomes The panels on the top and the right show the cells viewed from the sides. (3/4)

Cells are constantly managing energy, stress, and communication across a network of internal compartments called organelles. (1/4)