Charles Brenner, PhD

Modern life has tricked us into thinking travel is good. It's kind of barbaric for the body. Last time I went to Asia we measured my biomarkers. The data was bad… + 9 days for blood glucose stability + 9 days to re-entrain my circadian rhythm + 18 days for sleep architecture recovery The research: + people who travel constantly for work (3+ wks a month) have measurably more anxiety, depression, and drinking problems than people who don’t + repeated jet lag is linked to memory-region shrinkage in flight crews + your immune system takes a hit. Dry cabin air dries out mucous membranes that block infection which can leave you more exposed to getting sick This is intuitive because the body runs on a clock. Biological processes kicked off by another, with sleep + sun running the show. Cabin altitude is ~7,000 ft. Hypoxia alone disrupts cortisol and suppresses nocturnal melatonin for hours after you land. Cabin humidity drops as low as 5% (drier than the Sahara). If you’re budgeting your international trips: I’d suggest no more than once every 3 months. Evidence shows you need ~1 day per time zone to re-entrain, and east is worse than west. Once Kate gets back she’s starting the female protocol. This also means she can’t travel internationally for at least a few months while we collect baseline measurement. The body understands time zone changes as trauma. I hope that this is my last international trip for a very long time.

Always using the .005%🤣 Brad Pitt is his own category. Most men are not competing with that, and lying to them about it is honestly fucked up. Feeding them delusional fantasies is cruel. Same energy as telling women they can casually wait until 42 to think about kids because ✨science✨ or whatever. People love selling comforting exceptions while pretending statistical reality doesn’t exist. Biology does not care about internet coping mechanisms.

How does 5 years of data sound? BMI and GLP-1 trends are now available on the Epic Research Data Tracker: