Minhui Chen

Our perspective on heritable confounders in big GWAS meta-analyses on psychiatric disorders is now online @NatureGenet: nature.com/articles/s4158…, with @andywdahl, @jonathan_flint1, Richard Border et al. Small thread for context 1/n

Our paper, “Protein–protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits,” is now online in Nature Genetics. Link 👉 nature.com/articles/s4158…

Happy to share our new preprint from @SashaGusevPosts and @nmancuso_ labs! We introduce Mr. PEG, a framework integrating perturbational screens, eQTL, and GWAS data to identify mediating genes for complex traits. (1/n) medrxiv.org/content/10.648…

🧬 Do genetic variants interact in humans? For years, the answer was “probably, but we lacked solid statistical evidence.” We now bring one of the strongest pieces of evidence to date. Thrilled to share our latest work, FAME, now at Nature Genetics: nature.com/articles/s4158…

Great science happens at the intersections. STATGEN is a fantastic forum to connect, challenge assumptions, and raise the bar for rigor in genetics and genomics. Submit an abstract by December 15, 2025: forms.gle/4VgspgwTZpdELD… Conference Website: statgen26.emory.edu

1/3 Metacells boost power in single-cell RNA-seq & multiome analysis. But without checking homogeneity, they risk forming dubious metacells that bias discoveries. We introduce mcRigor: a statistical safeguard for rigorous metacell analysis. 👉 nature.com/articles/s4146…

🚀 Introducing Paper2Agent - a system that turns static research papers into interactive AI agents you can chat with and use the tools/data in the paper. Just ask, “Run this paper’s method on my data.” The paper agent will handle the task for you. 1/n

excited to share our new preprint looking at mosaic chromosomal alterations in blood whole genome sequencing data! i learned tons working on this project, and i hope our findings are of interest to those thinking about CH, somatic mosaicism, and genetics. medrxiv.org/content/10.110…

Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects act in sets”, a great effort led my PhD student @JolienRietkerk, and performed together with collaborators @andywdahl, @AndrewSchork, @jonathan_flint1 etc. Thread 1/n

Happy to share that our work from the @nmancuso_ lab is out in @NatureGenet! We developed SuShiE, a multiancestry fine-mapping method for molecular traits. doi.org/10.1038/s41588…

The fifth paper from the group this year. Led by a former postdoc @imyingchulo, our evaluation of polygenic scores (PGS) for BMI and T2D for Native Hawaiians is published in @CommsBio! nature.com/articles/s4200…

Check out our scPrediXcan paper cell.com/cell-genomics/… Led by talented @Charles_Zhou12, supervised by @MengjieChen6 and me, with thanks to many contributors scPrediXcan integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework.

Work with @jnovembre on extending FEEMS to represent long-range gene flow on a background migration surface! The software for the method, called FEEMSmix, is readily available at github.com/VivaswatS/feems #popgen #Genetics #evolution

Family members share quite a lot genetically and environmentally. Curious about how we quantify the resemblance using any possible genealogy-traceable relatives to study human phenotypes?Join us at Exhibit hall Board 4118w to explore our latest work! 😀 #ASHG24

Excited to be heading to #ASHG24 today! I’ll be presenting at Wednesday’s poster session (Board 3016W) about our latest work on spatial sampling strategies & deleterious variants - come say hi!

Eleanor is the best—she’s the kind of person who can tackle any challenge that comes her way. Any lab would be lucky to have her!

I am very excited to share my study, trans-regulation of proteome through protein-protein interactions, at #ASHG2024 ! Please check my poster number 6077 on Wednesday (11/6) afternoon!

Our work on trans regulation of proteome and how protein-protein interactions play a role in it🧬.

Excited to share our work on alternative splicing (AS) rdcu.be/dSHtu. This version, compared to the biorXiv one, is much more succinct due to word limits; I hope you will have a look. Congrats to @BenjaminFair3 and @cfbuenabad for their incredible work!🧵⬇️

My lab continues to explore questions on AS, unproductive splicing, and co/post-txnal gene regulation. I would love to hear from you if you might be interested in joining us — we are a small but well funded group for experimental and computational work. thelilab.com /n